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Cytosolic proteostasis through importing of misfolded proteins into mitochondria.
Ruan L, Zhou C, Jin E, Kucharavy A, Zhang Y, Wen Z, Florens L, Li R. Ruan L, et al. Nature. 2017 Mar 16;543(7645):443-446. doi: 10.1038/nature21695. Epub 2017 Mar 1. Nature. 2017. PMID: 28241148 Free PMC article.
Here we show that, in yeast, cytosolic proteins prone to aggregation are imported into mitochondria for degradation. ...Defects in cytosolic Hsp70s leads to enhanced entry of misfolded proteins into mitochondria and elevated …
Here we show that, in yeast, cytosolic proteins prone to aggregation are imported into mitochondria for degradat …
A cytosolic surveillance mechanism activates the mitochondrial UPR.
Sutandy FXR, Gößner I, Tascher G, Münch C. Sutandy FXR, et al. Nature. 2023 Jun;618(7966):849-854. doi: 10.1038/s41586-023-06142-0. Epub 2023 Jun 7. Nature. 2023. PMID: 37286597 Free PMC article.
The mitochondrial unfolded protein response (UPR(mt)) is essential to safeguard mitochondria from proteotoxic damage by activating a dedicated transcriptional response in the nucleus to restore proteostasis(1,2). ...Combining proteomics and genetic approaches …
The mitochondrial unfolded protein response (UPR(mt)) is essential to safeguard mitochondria from proteotoxic damage by activa …
Metabolic regulation of misfolded protein import into mitochondria.
Wang Y, Ruan L, Zhu J, Zhang X, Chih-Chieh Chang A, Tomaszewski A, Li R. Wang Y, et al. bioRxiv [Preprint]. 2023 Aug 31:2023.03.29.534670. doi: 10.1101/2023.03.29.534670. bioRxiv. 2023. PMID: 37034811 Free PMC article. Preprint.
Mitochondria also facilitate proteostasis through pathways such as the 'mitochondria as guardian in cytosol' (MAGIC) whereby cytosolic misfolded proteins (MPs) are imported into and degraded inside mitochondria. In th …
Mitochondria also facilitate proteostasis through pathways such as the 'mitochondria as guardian in cytosol' (MA …
Nascent mitochondrial proteins initiate the localized condensation of cytosolic protein aggregates on the mitochondrial surface.
Liu Q, Fong B, Yoo S, Unruh JR, Guo F, Yu Z, Chen J, Si K, Li R, Zhou C. Liu Q, et al. Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2300475120. doi: 10.1073/pnas.2300475120. Epub 2023 Jul 26. Proc Natl Acad Sci U S A. 2023. PMID: 37494397 Free PMC article.
Eukaryotes organize cellular contents into membrane-bound organelles and membrane-less condensates, for example, protein aggregates. An unsolved question is why the ubiquitously distributed proteins throughout the cytosol give rise to spatially localized p …
Eukaryotes organize cellular contents into membrane-bound organelles and membrane-less condensates, for example, protein aggregates. …
Mitochondrial control of cellular protein homeostasis.
Mohanraj K, Nowicka U, Chacinska A. Mohanraj K, et al. Biochem J. 2020 Aug 28;477(16):3033-3054. doi: 10.1042/BCJ20190654. Biochem J. 2020. PMID: 32845275 Review.
The majority of mitochondrial proteins are coded by nuclear DNA. Constant import of proteins from the cytosol is a prerequisite for the efficient functioning of the organelle. The protein import into mitochondria is mediated by div …
The majority of mitochondrial proteins are coded by nuclear DNA. Constant import of proteins from the cytosol is …
Stress Responses Elicited by Misfolded Proteins Targeted to Mitochondria.
Narayana Rao KB, Pandey P, Sarkar R, Ghosh A, Mansuri S, Ali M, Majumder P, Ranjith Kumar K, Ray A, Raychaudhuri S, Mapa K. Narayana Rao KB, et al. J Mol Biol. 2022 Jun 30;434(12):167618. doi: 10.1016/j.jmb.2022.167618. Epub 2022 Apr 30. J Mol Biol. 2022. PMID: 35500842
IMS and matrix possess contrasting oxido-reductive environments and discrete protein quality control (PQC) machineries resulting inherent differences in their protein folding environments. ...A general response to proteotoxic stress by mitochondria-targeted …
IMS and matrix possess contrasting oxido-reductive environments and discrete protein quality control (PQC) machineries resulting inhe …
Mitochondrial Quality Control and Cellular Proteostasis: Two Sides of the Same Coin.
Quiles JM, Gustafsson ÅB. Quiles JM, et al. Front Physiol. 2020 May 25;11:515. doi: 10.3389/fphys.2020.00515. eCollection 2020. Front Physiol. 2020. PMID: 32528313 Free PMC article. Review.
Almost all of the mitochondrial proteins are encoded by the nuclear genome and the trafficking of these nuclear-encoded proteins necessitates significant cross-talk with the cytosolic protein QC machinery to ensure that only functional proteins …
Almost all of the mitochondrial proteins are encoded by the nuclear genome and the trafficking of these nuclear-encoded proteins …
Consequences of inner mitochondrial membrane protein misfolding.
Coyne LP, Chen XJ. Coyne LP, et al. Mitochondrion. 2019 Nov;49:46-55. doi: 10.1016/j.mito.2019.06.001. Epub 2019 Jun 10. Mitochondrion. 2019. PMID: 31195097 Free PMC article. Review.
Maintaining the folding state of these proteins is therefore of the utmost importance, and this is ensured by IMM chaperones and proteases that refold and degrade unassembled and misfolded proteins. ...Finally, we summarize the mounting evidence that IMM prot …
Maintaining the folding state of these proteins is therefore of the utmost importance, and this is ensured by IMM chaperones and prot …
Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins.
Nowicka U, Chroscicki P, Stroobants K, Sladowska M, Turek M, Uszczynska-Ratajczak B, Kundra R, Goral T, Perni M, Dobson CM, Vendruscolo M, Chacinska A. Nowicka U, et al. Elife. 2021 Jul 20;10:e65484. doi: 10.7554/eLife.65484. Elife. 2021. PMID: 34292154 Free PMC article.
Mitochondria are organelles with their own genomes, but they rely on the import of nuclear-encoded proteins that are translated by cytosolic ribosomes. ...Here, we report that upon impairments in mitochondrial protein import, high-risk pr …
Mitochondria are organelles with their own genomes, but they rely on the import of nuclear-encoded proteins that are tr …
GPI-anchored Gas1 protein regulates cytosolic proteostasis in yeast.
Wang Y, Ruan L, Li R. Wang Y, et al. bioRxiv [Preprint]. 2023 May 26:2023.05.26.542479. doi: 10.1101/2023.05.26.542479. bioRxiv. 2023. PMID: 37292646 Free PMC article. Updated. Preprint.
Under proteotoxic stress, misfolded proteins that accumulate in cytosol can be imported into mitochondria for degradation via 'mitochondrial as guardian in cytosol' (MAGIC) pathway. ...But this mitochondria-associated GPI anchor si …
Under proteotoxic stress, misfolded proteins that accumulate in cytosol can be imported into mitochondria …
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