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Enzymatic activity of the Staphylococcus aureus SplB serine protease is induced by substrates containing the sequence Trp-Glu-Leu-Gln.
Dubin G, Stec-Niemczyk J, Kisielewska M, Pustelny K, Popowicz GM, Bista M, Kantyka T, Boulware KT, Stennicke HR, Czarna A, Phopaisarn M, Daugherty PS, Thøgersen IB, Enghild JJ, Thornberry N, Dubin A, Potempa J. Dubin G, et al. Among authors: czarna a. J Mol Biol. 2008 May 30;379(2):343-56. doi: 10.1016/j.jmb.2008.03.059. Epub 2008 Apr 3. J Mol Biol. 2008. PMID: 18448121
Molecular basis for the inhibition of p53 by Mdmx.
Popowicz GM, Czarna A, Rothweiler U, Szwagierczak A, Krajewski M, Weber L, Holak TA. Popowicz GM, et al. Among authors: czarna a. Cell Cycle. 2007 Oct 1;6(19):2386-92. doi: 10.4161/cc.6.19.4740. Epub 2007 Oct 12. Cell Cycle. 2007. PMID: 17938582
NMR screening for lead compounds using tryptophan-mutated proteins.
Rothweiler U, Czarna A, Weber L, Popowicz GM, Brongel K, Kowalska K, Orth M, Stemmann O, Holak TA. Rothweiler U, et al. Among authors: czarna a. J Med Chem. 2008 Aug 28;51(16):5035-42. doi: 10.1021/jm8002813. Epub 2008 Aug 5. J Med Chem. 2008. PMID: 18680271
Staphylococcal SplB serine protease utilizes a novel molecular mechanism of activation.
Pustelny K, Zdzalik M, Stach N, Stec-Niemczyk J, Cichon P, Czarna A, Popowicz G, Mak P, Drag M, Salvesen GS, Wladyka B, Potempa J, Dubin A, Dubin G. Pustelny K, et al. Among authors: czarna a. J Biol Chem. 2014 May 30;289(22):15544-53. doi: 10.1074/jbc.M113.507616. Epub 2014 Apr 8. J Biol Chem. 2014. PMID: 24713703 Free PMC article.
DYRK1A Kinase Inhibitors Promote β-Cell Survival and Insulin Homeostasis.
Barzowska A, Pucelik B, Pustelny K, Matsuda A, Martyniak A, Stępniewski J, Maksymiuk A, Dawidowski M, Rothweiler U, Dulak J, Dubin G, Czarna A. Barzowska A, et al. Among authors: czarna a. Cells. 2021 Aug 31;10(9):2263. doi: 10.3390/cells10092263. Cells. 2021. PMID: 34571911 Free PMC article.
Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses.
Napolitano V, Dabrowska A, Schorpp K, Mourão A, Barreto-Duran E, Benedyk M, Botwina P, Brandner S, Bostock M, Chykunova Y, Czarna A, Dubin G, Fröhlich T, Hölscher M, Jedrysik M, Matsuda A, Owczarek K, Pachota M, Plettenburg O, Potempa J, Rothenaigner I, Schlauderer F, Slysz K, Szczepanski A, Greve-Isdahl Mohn K, Blomberg B, Sattler M, Hadian K, Popowicz GM, Pyrc K. Napolitano V, et al. Among authors: czarna a. Cell Chem Biol. 2022 May 19;29(5):774-784.e8. doi: 10.1016/j.chembiol.2021.11.006. Epub 2022 Jan 11. Cell Chem Biol. 2022. PMID: 35021060 Free PMC article.
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