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Targeting Huntingtin Expression in Patients with Huntington's Disease.
Tabrizi SJ, Leavitt BR, Landwehrmeyer GB, Wild EJ, Saft C, Barker RA, Blair NF, Craufurd D, Priller J, Rickards H, Rosser A, Kordasiewicz HB, Czech C, Swayze EE, Norris DA, Baumann T, Gerlach I, Schobel SA, Paz E, Smith AV, Bennett CF, Lane RM; Phase 1–2a IONIS-HTTRx Study Site Teams. Tabrizi SJ, et al. Among authors: Czech C. N Engl J Med. 2019 Jun 13;380(24):2307-2316. doi: 10.1056/NEJMoa1900907. Epub 2019 May 6. N Engl J Med. 2019. PMID: 31059641 Clinical Trial.
Evaluation of mutant huntingtin and neurofilament proteins as potential markers in Huntington's disease.
Byrne LM, Rodrigues FB, Johnson EB, Wijeratne PA, De Vita E, Alexander DC, Palermo G, Czech C, Schobel S, Scahill RI, Heslegrave A, Zetterberg H, Wild EJ. Byrne LM, et al. Among authors: Czech C. Sci Transl Med. 2018 Sep 12;10(458):eaat7108. doi: 10.1126/scitranslmed.aat7108. Sci Transl Med. 2018. PMID: 30209243
Sembragiline in Moderate Alzheimer's Disease: Results of a Randomized, Double-Blind, Placebo-Controlled Phase II Trial (MAyflOwer RoAD).
Nave S, Doody RS, Boada M, Grimmer T, Savola JM, Delmar P, Pauly-Evers M, Nikolcheva T, Czech C, Borroni E, Ricci B, Dukart J, Mannino M, Carey T, Moran E, Gilaberte I, Muelhardt NM, Gerlach I, Santarelli L, Ostrowitzki S, Fontoura P. Nave S, et al. Among authors: Czech C. J Alzheimers Dis. 2017;58(4):1217-1228. doi: 10.3233/JAD-161309. J Alzheimers Dis. 2017. PMID: 28550255 Free PMC article. Clinical Trial.
Metabolite profiling of Alzheimer's disease cerebrospinal fluid.
Czech C, Berndt P, Busch K, Schmitz O, Wiemer J, Most V, Hampel H, Kastler J, Senn H. Czech C, et al. PLoS One. 2012;7(2):e31501. doi: 10.1371/journal.pone.0031501. Epub 2012 Feb 16. PLoS One. 2012. PMID: 22359596 Free PMC article.
Peripheral mitochondrial dysfunction in Alzheimer's disease: focus on lymphocytes.
Leuner K, Schulz K, Schütt T, Pantel J, Prvulovic D, Rhein V, Savaskan E, Czech C, Eckert A, Müller WE. Leuner K, et al. Among authors: Czech C. Mol Neurobiol. 2012 Aug;46(1):194-204. doi: 10.1007/s12035-012-8300-y. Epub 2012 Jul 22. Mol Neurobiol. 2012. PMID: 22821186 Review.
Effect of the mGluR5-NAM Basimglurant on Behavior in Adolescents and Adults with Fragile X Syndrome in a Randomized, Double-Blind, Placebo-Controlled Trial: FragXis Phase 2 Results.
Youssef EA, Berry-Kravis E, Czech C, Hagerman RJ, Hessl D, Wong CY, Rabbia M, Deptula D, John A, Kinch R, Drewitt P, Lindemann L, Marcinowski M, Langland R, Horn C, Fontoura P, Santarelli L, Quiroz JA; FragXis Study Group. Youssef EA, et al. Among authors: Czech C. Neuropsychopharmacology. 2018 Feb;43(3):503-512. doi: 10.1038/npp.2017.177. Epub 2017 Aug 17. Neuropsychopharmacology. 2018. PMID: 28816242 Free PMC article. Clinical Trial.
Patients with autism spectrum disorders display reproducible functional connectivity alterations.
Holiga Š, Hipp JF, Chatham CH, Garces P, Spooren W, D'Ardhuy XL, Bertolino A, Bouquet C, Buitelaar JK, Bours C, Rausch A, Oldehinkel M, Bouvard M, Amestoy A, Caralp M, Gueguen S, Ly-Le Moal M, Houenou J, Beckmann CF, Loth E, Murphy D, Charman T, Tillmann J, Laidi C, Delorme R, Beggiato A, Gaman A, Scheid I, Leboyer M, d'Albis MA, Sevigny J, Czech C, Bolognani F, Honey GD, Dukart J. Holiga Š, et al. Among authors: Czech C. Sci Transl Med. 2019 Feb 27;11(481):eaat9223. doi: 10.1126/scitranslmed.aat9223. Sci Transl Med. 2019. PMID: 30814340
Longitudinal characterization of biomarkers for spinal muscular atrophy.
Bonati U, Holiga Š, Hellbach N, Risterucci C, Bergauer T, Tang W, Hafner P, Thoeni A, Bieri O, Gerlach I, Marquet A, Khwaja O, Sambataro F, Bertolino A, Dukart J, Fischmann A, Fischer D, Czech C. Bonati U, et al. Among authors: Czech C. Ann Clin Transl Neurol. 2017 Apr 11;4(5):292-304. doi: 10.1002/acn3.406. eCollection 2017 May. Ann Clin Transl Neurol. 2017. PMID: 28491897 Free PMC article.
Chemically-defined camelid antibody bioconjugate for the magnetic resonance imaging of Alzheimer's disease.
Vandesquille M, Li T, Po C, Ganneau C, Lenormand P, Dudeffant C, Czech C, Grueninger F, Duyckaerts C, Delatour B, Dhenain M, Lafaye P, Bay S. Vandesquille M, et al. Among authors: Czech C. MAbs. 2017 Aug/Sep;9(6):1016-1027. doi: 10.1080/19420862.2017.1342914. Epub 2017 Jun 28. MAbs. 2017. PMID: 28657418 Free PMC article.
In contrast to the random strategy, the site-specific conjugation to a single reduced cysteine in the C-terminal part of the R3VQ generates a well-defined bioconjugate in a high yield process. ...
In contrast to the random strategy, the site-specific conjugation to a single reduced cysteine in the C-terminal part of the R3VQ gen …
Identification of Three Novel Radiotracers for Imaging Aggregated Tau in Alzheimer's Disease with Positron Emission Tomography.
Gobbi LC, Knust H, Körner M, Honer M, Czech C, Belli S, Muri D, Edelmann MR, Hartung T, Erbsmehl I, Grall-Ulsemer S, Koblet A, Rueher M, Steiner S, Ravert HT, Mathews WB, Holt DP, Kuwabara H, Valentine H, Dannals RF, Wong DF, Borroni E. Gobbi LC, et al. Among authors: Czech C. J Med Chem. 2017 Sep 14;60(17):7350-7370. doi: 10.1021/acs.jmedchem.7b00632. Epub 2017 Jul 12. J Med Chem. 2017. PMID: 28654263
As a result of this work, we discovered three novel PET tracers (2-(4-[(11)C]methoxyphenyl)imidazo[1,2-a]pyridin-7-amine 7 ([(11)C]RO6924963), N-[(11)C]methyl-2-(3-methylphenyl)imidazo[1,2-a]pyrimidin-7-amine 8 ([(11)C]RO6931643), and [(18)F]2-(6-fluor …
As a result of this work, we discovered three novel PET tracers (2-(4-[(11)C]methoxyphenyl)imidazo[1,2-a]pyridin-7-amine 7 ([(11)C
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