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Copper enhances aggregational toxicity of mutant huntingtin in a Drosophila model of Huntington's Disease.
Lobato AG, Ortiz-Vega N, Zhu Y, Neupane D, Meier KK, Zhai RG. Lobato AG, et al. Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870(1):166928. doi: 10.1016/j.bbadis.2023.166928. Epub 2023 Oct 28. Biochim Biophys Acta Mol Basis Dis. 2024. PMID: 38660915
Specifically, we found that copper increases mutant Htt aggregation, enhances the accumulation of Thioflavin S positive beta-amyloid structures within Htt aggregates, and consequently alters autophagy in the brain. Administration of copper chelator D-penicillamine (DPA) th …
Specifically, we found that copper increases mutant Htt aggregation, enhances the accumulation of Thioflavin S positive beta-amyloid structu …
[Characteristics of drug resistance and biofilm formation in carbapenem-resistant Acinetobacter baumannii in hospitalized children].
Li YY, Liu HC, Wang HP, DU TY, Jiang L. Li YY, et al. Zhongguo Dang Dai Er Ke Za Zhi. 2024 Apr 15;26(4):358-364. doi: 10.7499/j.issn.1008-8830.2309058. Zhongguo Dang Dai Er Ke Za Zhi. 2024. PMID: 38660899 Chinese.
RESULTS: Both the 22 epidemic strains and the 26 sporadic strains were producers of Class D carbapenemases or extended-spectrum beta-lactamases with downregulated outer membrane porins, harboring the VIM, OXA-23, and OXA-51 genes. ...
RESULTS: Both the 22 epidemic strains and the 26 sporadic strains were producers of Class D carbapenemases or extended-spectrum beta- …
A cross-sectional study on the potential drug-drug interaction risk of COVID-19 patients in hospital.
Huang LL, Jiang B, Han YL, Liu Y. Huang LL, et al. Int J Clin Pharmacol Ther. 2024 Apr 25. doi: 10.5414/CP204435. Online ahead of print. Int J Clin Pharmacol Ther. 2024. PMID: 38660885
The results of this study showed that a total of 152 (28.84%) prescriptions had 270 X risk class potential DDIs (i.e., avoid combining), 313 (59.39%) prescriptions had 1,161 D risk class potential DDIs (i.e., consider therapy modification), and 476 (90.32%) prescriptions h …
The results of this study showed that a total of 152 (28.84%) prescriptions had 270 X risk class potential DDIs (i.e., avoid combining), 313 …
[Effect of Low-Dose Recombinant Interleukin-2 Therapy on Immunocyte Subsets in Children with Solid Tumor].
Lei JY, Li Y, Li CM, Xiong XL, Feng CC, Weng WJ, Peng XM, Zhou DH, Huang K. Lei JY, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2024 Apr;32(2):445-449. doi: 10.19746/j.cnki.issn.1009-2137.2024.02.019. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2024. PMID: 38660850 Chinese.
A low-dose rIL-2 therapy was given 1 month after chemotherapy for 1 year: 410(5) IU/(m(2).d), s.c. for every other day, 3 times per week. The immunocyte subsets were detected every 3 months until the end of treatment, meanwhile, disease condition and therapy-related side e …
A low-dose rIL-2 therapy was given 1 month after chemotherapy for 1 year: 410(5) IU/(m(2).d), s.c. for every other day, 3 times per w …
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