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Oral lasofoxifene's effects on moderate to severe vaginal atrophy in postmenopausal women: two phase 3, randomized, controlled trials.
Kagan R, Simon JA, Goldstein SR, Komm BS, Jenkins SN, Portman DJ. Kagan R, et al. Menopause. 2024 Apr 23. doi: 10.1097/GME.0000000000002355. Online ahead of print. Menopause. 2024. PMID: 38652875

Coprimary endpoints at week 12 improved with lasofoxifene 0.25 and 0.5 mg/d greater than with placebo (P < 0.0125 for all). Study 1: most bothersome symptom (least square mean difference from placebo: -0.4 and -0.5 for 0.25 and 0.5 mg/d, respectively), vaginal pH

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Coprimary endpoints at week 12 improved with lasofoxifene 0.25 and 0.5 mg/d greater than with placebo (P < 0.0125 for all). Study

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Visualization of Endogenous Hypochlorite in Drug-Induced Liver Injury Mice via a Bioluminescent Probe Combined with Firefly Luciferase mRNA-Loaded Lipid Nanoparticles.
Yang J, Chen Z, Yang Y, Zheng B, Zhu Y, Wu F, Xiong H. Yang J, et al. Anal Chem. 2024 Apr 23. doi: 10.1021/acs.analchem.4c00008. Online ahead of print. Anal Chem. 2024. PMID: 38652863
In the presence of ClO(-), probe ClO-Luc locked by formylhydrazine could release cage-free d-luciferin through oxidation and follow-up hydrolysis reactions, further allowing for bioluminescence imaging. ...
In the presence of ClO(-), probe ClO-Luc locked by formylhydrazine could release cage-free d-luciferin through oxidation and follow-u …
Virtual Care: Perspectives From Family Physicians.
Ritchie O, Koptyra E, Marquis LB, Kadri R, Laurie AR, Vydiswaran VGV, Li J, Brown LK, Veinot TC, Buis LR, Guetterman TC. Ritchie O, et al. Fam Med. 2024 Apr 15. doi: 10.22454/FamMed.2024.592756. Online ahead of print. Fam Med. 2024. PMID: 38652849
RESULTS: The results of the analysis identified four major themes: (a) chief concerns that are appropriate for virtual evaluation, (b) physician perceptions of patient benefits, (c) focused but contextually enriched patient-physician communication, and (d) structural suppo …
RESULTS: The results of the analysis identified four major themes: (a) chief concerns that are appropriate for virtual evaluation, (b) physi …
Nanoparticle Retinoic Acid-Inducible Gene I Agonist for Cancer Immunotherapy.
Wang-Bishop L, Wehbe M, Pastora LE, Yang J, Kimmel BR, Garland KM, Becker KW, Carson CS, Roth EW, Gibson-Corley KN, Ulkoski D, Krishnamurthy V, Fedorova O, Richmond A, Pyle AM, Wilson JT. Wang-Bishop L, et al. ACS Nano. 2024 Apr 23. doi: 10.1021/acsnano.3c06225. Online ahead of print. ACS Nano. 2024. PMID: 38652829
Tuning Electrocatalytic Activities of Dealloyed Nanoporous Catalysts by Macroscopic Strain Engineering.
Li Q, Kudo A, Ma J, Kawashima R, Toyama K, Xu W, Gao Z, Liang Y, Jiang H, Li Z, Cui Z, Zhu S, Chen M. Li Q, et al. Nano Lett. 2024 Apr 23. doi: 10.1021/acs.nanolett.4c00781. Online ahead of print. Nano Lett. 2024. PMID: 38652819
It was found that macroscopic compressive strains lead to a decrease, while macroscopic tensile strains improve the HER activity of NPG, which is in line with the d-band center model. The overpotential and onset potential of HER display approximately a linear relation with …
It was found that macroscopic compressive strains lead to a decrease, while macroscopic tensile strains improve the HER activity of NPG, whi …
Impact of Spin-Entropy on the Thermoelectric Properties of a 2D Magnet.
Canetta A, Volosheniuk S, Satheesh S, Alvarinhas Batista JP, Castellano A, Conte R, Chica DG, Watanabe K, Taniguchi T, Roy X, van der Zant HSJ, Burghard M, Verstraete MJ, Gehring P. Canetta A, et al. Nano Lett. 2024 Apr 23. doi: 10.1021/acs.nanolett.4c00809. Online ahead of print. Nano Lett. 2024. PMID: 38652810
The narrow footprint of ancient balancing selection revealed by heterokaryon incompatibility genes in Aspergillus fumigatus.
Auxier B, Zhang J, Marquez FR, Senden K, van den Heuvel J, Aanen DK, Snelders E, Debets AJM. Auxier B, et al. Mol Biol Evol. 2024 Apr 23:msae079. doi: 10.1093/molbev/msae079. Online ahead of print. Mol Biol Evol. 2024. PMID: 38652808
Surprisingly, a sliding window genome-wide population-level analysis of an independent dataset did not show increased Tajima's D near these loci, in contrast to what is often found surrounding loci under balancing selection. ...
Surprisingly, a sliding window genome-wide population-level analysis of an independent dataset did not show increased Tajima's D near …
Low-latency gravitational wave alert products and their performance at the time of the fourth LIGO-Virgo-KAGRA observing run.
Chaudhary SS, Toivonen A, Waratkar G, Mo G, Chatterjee D, Antier S, Brockill P, Coughlin MW, Essick R, Ghosh S, Morisaki S, Baral P, Baylor A, Adhikari N, Brady P, Cabourn Davies G, Dal Canton T, Cavaglia M, Creighton J, Choudhary S, Chu YK, Clearwater P, Davis L, Dent T, Drago M, Ewing B, Godwin P, Guo W, Hanna C, Huxford R, Harry I, Katsavounidis E, Kovalam M, Li AKY, Magee R, Marx E, Meacher D, Messick C, Morice-Atkinson X, Pace A, De Pietri R, Piotrzkowski B, Roy S, Sachdev S, Singer LP, Singh D, Szczepanczyk M, Tang D, Trevor M, Tsukada L, Villa-Ortega V, Wen L, Wysocki D. Chaudhary SS, et al. Proc Natl Acad Sci U S A. 2024 Apr 30;121(18):e2316474121. doi: 10.1073/pnas.2316474121. Epub 2024 Apr 23. Proc Natl Acad Sci U S A. 2024. PMID: 38652749
Magnesium and vitamin D in long COVID syndrome; do they help?
Wolf FI, Trapani V. Wolf FI, et al. Magnes Res. 2024 Apr 23;0(0). doi: 10.1684/mrh.2024.0521. Online ahead of print. Magnes Res. 2024. PMID: 38652733
Here we discuss recent evidence suggesting that, in long COVID patients, combined magnesium and vitamin D deficiencies associate with a higher number of clinical manifestations, as compared to patients with normal levels of both nutrients. ...Most importantly, randomized c …
Here we discuss recent evidence suggesting that, in long COVID patients, combined magnesium and vitamin D deficiencies associate with …
Correlation between maternal and umbilical cord 25-hydroxy-vitamin D levels over a range of values. A prospective observational study from the United Arab Emirates.
Jutell M, Bhat S, Bagge ML, Isberg PE, Wiberg N. Jutell M, et al. PLoS One. 2024 Apr 23;19(4):e0299862. doi: 10.1371/journal.pone.0299862. eCollection 2024. PLoS One. 2024. PMID: 38652723
The total amount of the vitamin is best measured by 25-hydroxy-vitamin D (25(OH)D), which is a measurement of total serum cholecalciferol 25(OH)D3 and ergocalciferol 25(OH)D2. ...In summary, the correlation between maternal and UCB 25(OH)D is very strong thro …
The total amount of the vitamin is best measured by 25-hydroxy-vitamin D (25(OH)D), which is a measurement of total serum chol …
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