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The conformational state of hERG1 channels determines integrin association, downstream signaling, and cancer progression.
Becchetti A, Crescioli S, Zanieri F, Petroni G, Mercatelli R, Coppola S, Gasparoli L, D'Amico M, Pillozzi S, Crociani O, Stefanini M, Fiore A, Carraresi L, Morello V, Manoli S, Brizzi MF, Ricci D, Rinaldi M, Masi A, Schmidt T, Quercioli F, Defilippi P, Arcangeli A. Becchetti A, et al. Sci Signal. 2017 Apr 4;10(473):eaaf3236. doi: 10.1126/scisignal.aaf3236. Sci Signal. 2017. PMID: 28377405 Free article.
hERG1 channels regulate VEGF-A secretion in human gastric cancer: clinicopathological correlations and therapeutical implications.
Crociani O, Lastraioli E, Boni L, Pillozzi S, Romoli MR, D'Amico M, Stefanini M, Crescioli S, Masi A, Taddei A, Bencini L, Bernini M, Farsi M, Beghelli S, Scarpa A, Messerini L, Tomezzoli A, Vindigni C, Morgagni P, Saragoni L, Giommoni E, Gasperoni S, Di Costanzo F, Roviello F, De Manzoni G, Bechi P, Arcangeli A. Crociani O, et al. Clin Cancer Res. 2014 Mar 15;20(6):1502-12. doi: 10.1158/1078-0432.CCR-13-2633. Epub 2014 Jan 21. Clin Cancer Res. 2014. PMID: 24449824
The combined activation of KCa3.1 and inhibition of Kv11.1/hERG1 currents contribute to overcome Cisplatin resistance in colorectal cancer cells.
Pillozzi S, D'Amico M, Bartoli G, Gasparoli L, Petroni G, Crociani O, Marzo T, Guerriero A, Messori L, Severi M, Udisti R, Wulff H, Chandy KG, Becchetti A, Arcangeli A. Pillozzi S, et al. Br J Cancer. 2018 Jan;118(2):200-212. doi: 10.1038/bjc.2017.392. Epub 2017 Nov 21. Br J Cancer. 2018. PMID: 29161243 Free PMC article.
hERG1 channels drive tumour malignancy and may serve as prognostic factor in pancreatic ductal adenocarcinoma.
Lastraioli E, Perrone G, Sette A, Fiore A, Crociani O, Manoli S, D'Amico M, Masselli M, Iorio J, Callea M, Borzomati D, Nappo G, Bartolozzi F, Santini D, Bencini L, Farsi M, Boni L, Di Costanzo F, Schwab A, Onetti Muda A, Coppola R, Arcangeli A. Lastraioli E, et al. Br J Cancer. 2015 Mar 17;112(6):1076-87. doi: 10.1038/bjc.2015.28. Br J Cancer. 2015. PMID: 25719829 Free PMC article.
739 results