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Page 1
GADD45β Loss Ablates Innate Immunosuppression in Cancer.
Verzella D, Bennett J, Fischietti M, Thotakura AK, Recordati C, Pasqualini F, Capece D, Vecchiotti D, D'Andrea D, Di Francesco B, De Maglie M, Begalli F, Tornatore L, Papa S, Lawrence T, Forbes SJ, Sica A, Alesse E, Zazzeroni F, Franzoso G. Verzella D, et al. Cancer Res. 2018 Mar 1;78(5):1275-1292. doi: 10.1158/0008-5472.CAN-17-1833. Epub 2017 Dec 26. Cancer Res. 2018. PMID: 29279355 Free PMC article.
Cancer-selective targeting of the NF-κB survival pathway with GADD45β/MKK7 inhibitors.
Tornatore L, Sandomenico A, Raimondo D, Low C, Rocci A, Tralau-Stewart C, Capece D, D'Andrea D, Bua M, Boyle E, van Duin M, Zoppoli P, Jaxa-Chamiec A, Thotakura AK, Dyson J, Walker BA, Leonardi A, Chambery A, Driessen C, Sonneveld P, Morgan G, Palumbo A, Tramontano A, Rahemtulla A, Ruvo M, Franzoso G. Tornatore L, et al. Cancer Cell. 2014 Oct 13;26(4):495-508. doi: 10.1016/j.ccr.2014.07.027. Cancer Cell. 2014. PMID: 25314077 Free PMC article.
NF-κB in the crosshairs: Rethinking an old riddle.
Bennett J, Capece D, Begalli F, Verzella D, D'Andrea D, Tornatore L, Franzoso G. Bennett J, et al. Int J Biochem Cell Biol. 2018 Feb;95:108-112. doi: 10.1016/j.biocel.2017.12.020. Epub 2017 Dec 23. Int J Biochem Cell Biol. 2018. PMID: 29277662 Free PMC article. Review.
Turning an old GADDget into a troublemaker.
Capece D, D'Andrea D, Verzella D, Tornatore L, Begalli F, Bennett J, Zazzeroni F, Franzoso G. Capece D, et al. Cell Death Differ. 2018 Mar;25(4):642-644. doi: 10.1038/s41418-018-0087-6. Epub 2018 Mar 6. Cell Death Differ. 2018. PMID: 29511335 Free PMC article. Review. No abstract available.
Enhanced triacylglycerol catabolism by carboxylesterase 1 promotes aggressive colorectal carcinoma.
Capece D, D'Andrea D, Begalli F, Goracci L, Tornatore L, Alexander JL, Di Veroli A, Leow SC, Vaiyapuri TS, Ellis JK, Verzella D, Bennett J, Savino L, Ma Y, McKenzie JS, Doria ML, Mason SE, Chng KR, Keun HC, Frost G, Tergaonkar V, Broniowska K, Stunkel W, Takats Z, Kinross JM, Cruciani G, Franzoso G. Capece D, et al. J Clin Invest. 2021 Jun 1;131(11):e137845. doi: 10.1172/JCI137845. J Clin Invest. 2021. PMID: 33878036 Free PMC article.
Preclinical toxicology and safety pharmacology of the first-in-class GADD45β/MKK7 inhibitor and clinical candidate, DTP3.
Tornatore L, Capece D, D'Andrea D, Begalli F, Verzella D, Bennett J, Acton G, Campbell EA, Kelly J, Tarbit M, Adams N, Bannoo S, Leonardi A, Sandomenico A, Raimondo D, Ruvo M, Chambery A, Oblak M, Al-Obaidi MJ, Kaczmarski RS, Gabriel I, Oakervee HE, Kaiser MF, Wechalekar A, Benjamin R, Apperley JF, Auner HW, Franzoso G. Tornatore L, et al. Toxicol Rep. 2019 Apr 19;6:369-379. doi: 10.1016/j.toxrep.2019.04.006. eCollection 2019. Toxicol Rep. 2019. PMID: 31080744 Free PMC article.
306 results