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Shedding light on the cell biology of extracellular vesicles.
van Niel G, D'Angelo G, Raposo G. van Niel G, et al. Nat Rev Mol Cell Biol. 2018 Apr;19(4):213-228. doi: 10.1038/nrm.2017.125. Epub 2018 Jan 17. Nat Rev Mol Cell Biol. 2018. PMID: 29339798 Review.
The ESCRT machinery regulates the secretion and long-range activity of Hedgehog.
Matusek T, Wendler F, Polès S, Pizette S, D'Angelo G, Fürthauer M, Thérond PP. Matusek T, et al. Nature. 2014 Dec 4;516(7529):99-103. doi: 10.1038/nature13847. Nature. 2014. PMID: 25471885
Endocytosis of Hedgehog through dispatched regulates long-range signaling.
D'Angelo G, Matusek T, Pizette S, Thérond PP. D'Angelo G, et al. Dev Cell. 2015 Feb 9;32(3):290-303. doi: 10.1016/j.devcel.2014.12.004. Epub 2015 Jan 22. Dev Cell. 2015. PMID: 25619925
A genome-wide RNAi screen identifies regulators of cholesterol-modified hedgehog secretion in Drosophila.
Aikin R, Cervantes A, D'Angelo G, Ruel L, Lacas-Gervais S, Schaub S, Thérond P. Aikin R, et al. PLoS One. 2012;7(3):e33665. doi: 10.1371/journal.pone.0033665. Epub 2012 Mar 14. PLoS One. 2012. PMID: 22432040 Free PMC article.
Soluble nickel interferes with cellular iron homeostasis.
Davidson T, Chen H, Garrick MD, D'Angelo G, Costa M. Davidson T, et al. Mol Cell Biochem. 2005 Nov;279(1-2):157-62. doi: 10.1007/s11010-005-8288-y. Mol Cell Biochem. 2005. PMID: 16283525
Analysis of the hypoxia-sensing pathway in Drosophila melanogaster.
Arquier N, Vigne P, Duplan E, Hsu T, Therond PP, Frelin C, D'Angelo G. Arquier N, et al. Biochem J. 2006 Jan 15;393(Pt 2):471-80. doi: 10.1042/BJ20050675. Biochem J. 2006. PMID: 16176182 Free PMC article.
The full-length unprocessed hedgehog protein is an active signaling molecule.
Tokhunts R, Singh S, Chu T, D'Angelo G, Baubet V, Goetz JA, Huang Z, Yuan Z, Ascano M, Zavros Y, Thérond PP, Kunes S, Dahmane N, Robbins DJ. Tokhunts R, et al. J Biol Chem. 2010 Jan 22;285(4):2562-8. doi: 10.1074/jbc.M109.078626. Epub 2009 Nov 17. J Biol Chem. 2010. PMID: 19920144 Free PMC article.
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