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Cenicriviroc, a dual CCR2 and CCR5 antagonist leads to a reduction in plasma fibrotic biomarkers in persons living with HIV on antiretroviral therapy.
Bowler S, Siriwardhana C, Mitchell BI, D'Antoni ML, Ogata-Arakaki D, Souza S, Yee R, Gangcuangco LMA, Chow DC, Ndhlovu LC, Shikuma C. Bowler S, et al. Among authors: d antoni ml. HIV Res Clin Pract. 2019 Aug-Oct;20(4-5):123-129. doi: 10.1080/25787489.2020.1719319. Epub 2020 Feb 4. HIV Res Clin Pract. 2019. PMID: 32013805 Clinical Trial.
IL-1Β enriched monocytes mount massive IL-6 responses to common inflammatory triggers among chronically HIV-1 infected adults on stable anti-retroviral therapy at risk for cardiovascular disease.
Jalbert E, Crawford TQ, D'Antoni ML, Keating SM, Norris PJ, Nakamoto BK, Seto T, Parikh NI, Shikuma CM, Ndhlovu LC, Barbour JD. Jalbert E, et al. PLoS One. 2013 Sep 25;8(9):e75500. doi: 10.1371/journal.pone.0075500. eCollection 2013. PLoS One. 2013. PMID: 24086545 Free PMC article.
Loss of CCR2 expressing non-classical monocytes are associated with cognitive impairment in antiretroviral therapy-naïve HIV-infected Thais.
Ndhlovu LC, D'Antoni ML, Ananworanich J, Byron MM, Chalermchai T, Sithinamsuwan P, Tipsuk S, Ho E, Slike BM, Schuetz A, Zhang G, Agsalda-Garcia M, Shiramizu B, Shikuma CM, Valcour V; SEARCH 011 study group. Ndhlovu LC, et al. J Neuroimmunol. 2015 Nov 15;288:25-33. doi: 10.1016/j.jneuroim.2015.08.020. Epub 2015 Sep 4. J Neuroimmunol. 2015. PMID: 26531691 Free PMC article.
Improved Cognitive Performance and Reduced Monocyte Activation in Virally Suppressed Chronic HIV After Dual CCR2 and CCR5 Antagonism.
DʼAntoni ML, Paul RH, Mitchell BI, Kohorn L, Fischer L, Lefebvre E, Seyedkazemi S, Nakamoto BK, Walker M, Kallianpur KJ, Ogata-Arakaki D, Ndhlovu LC, Shikuma C. DʼAntoni ML, et al. J Acquir Immune Defic Syndr. 2018 Sep 1;79(1):108-116. doi: 10.1097/QAI.0000000000001752. J Acquir Immune Defic Syndr. 2018. PMID: 29781885 Free PMC article. Clinical Trial.
Normalization of Soluble CD163 Levels After Institution of Antiretroviral Therapy During Acute HIV Infection Tracks with Fewer Neurological Abnormalities.
D'Antoni ML, Byron MM, Chan P, Sailasuta N, Sacdalan C, Sithinamsuwan P, Tipsuk S, Pinyakorn S, Kroon E, Slike BM, Krebs SJ, Khadka VS, Chalermchai T, Kallianpur KJ, Robb M, Spudich S, Valcour V, Ananworanich J, Ndhlovu LC; RV254/SEARCH010, SEARCH011, and RV304/SEARCH013 Study Groups. D'Antoni ML, et al. J Infect Dis. 2018 Sep 22;218(9):1453-1463. doi: 10.1093/infdis/jiy337. J Infect Dis. 2018. PMID: 29868826 Free PMC article. Clinical Trial.
Elevated cerebrospinal fluid Galectin-9 is associated with central nervous system immune activation and poor cognitive performance in older HIV-infected individuals.
Premeaux TA, D'Antoni ML, Abdel-Mohsen M, Pillai SK, Kallianpur KJ, Nakamoto BK, Agsalda-Garcia M, Shiramizu B, Shikuma CM, Gisslén M, Price RW, Valcour V, Ndhlovu LC. Premeaux TA, et al. J Neurovirol. 2019 Apr;25(2):150-161. doi: 10.1007/s13365-018-0696-3. Epub 2018 Nov 26. J Neurovirol. 2019. PMID: 30478799 Free PMC article.
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