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Transcription of repA, the gene of the initiation protein of the Pseudomonas plasmid pPS10, is autoregulated by interactions of the RepA protein at a symmetrical operator.
García de Viedma D, Giraldo R, Ruiz-Echevarría MJ, Lurz R, Díaz-Orejas R. García de Viedma D, et al. J Mol Biol. 1995 Mar 24;247(2):211-23. doi: 10.1006/jmbi.1994.0134. J Mol Biol. 1995. PMID: 7707370
Identification of residues of the kid toxin involved in autoregulation of the parD system.
Lemonnier M, Santos-Sierra S, Pardo-Abarrio C, Díaz-Orejas R. Lemonnier M, et al. J Bacteriol. 2004 Jan;186(1):240-3. doi: 10.1128/jb.186.1.240-243.2004. J Bacteriol. 2004. PMID: 14679244 Free PMC article.
Cleavage of the antitoxin of the parD toxin-antitoxin system is determined by the ClpAP protease and is modulated by the relative ratio of the toxin and the antitoxin.
Diago-Navarro E, Hernández-Arriaga AM, Kubik S, Konieczny I, Díaz-Orejas R. Diago-Navarro E, et al. Among authors: diaz orejas r. Plasmid. 2013 Jul;70(1):78-85. doi: 10.1016/j.plasmid.2013.01.010. Epub 2013 Feb 15. Plasmid. 2013. PMID: 23419648
Insights into the specificity of RNA cleavage by the Escherichia coli MazF toxin.
Muñoz-Gómez AJ, Santos-Sierra S, Berzal-Herranz A, Lemonnier M, Díaz-Orejas R. Muñoz-Gómez AJ, et al. FEBS Lett. 2004 Jun 4;567(2-3):316-20. doi: 10.1016/j.febslet.2004.05.005. FEBS Lett. 2004. PMID: 15178344
Bacteriophage P1 Ban protein is a hexameric DNA helicase that interacts with and substitutes for Escherichia coli DnaB.
Lemonnier M, Ziegelin G, Reick T, Muñoz Gómez A, Díaz-Orejas R, Lanka E. Lemonnier M, et al. Nucleic Acids Res. 2003 Jul 15;31(14):3918-28. doi: 10.1093/nar/gkg463. Nucleic Acids Res. 2003. PMID: 12853607 Free PMC article.
A conformational switch between transcriptional repression and replication initiation in the RepA dimerization domain.
Giraldo R, Fernández-Tornero C, Evans PR, Díaz-Orejas R, Romero A. Giraldo R, et al. Nat Struct Biol. 2003 Jul;10(7):565-71. doi: 10.1038/nsb937. Nat Struct Biol. 2003. PMID: 12766757
Modulation of pPS10 host range by plasmid-encoded RepA initiator protein.
Maestro B, Sanz JM, Díaz-Orejas R, Fernández-Tresguerres E. Maestro B, et al. J Bacteriol. 2003 Feb;185(4):1367-75. doi: 10.1128/jb.185.4.1367-1375.2003. J Bacteriol. 2003. PMID: 12562807 Free PMC article.
Coupling between the basic replicon and the Kis-Kid maintenance system of plasmid R1: modulation by Kis antitoxin levels and involvement in control of plasmid replication.
López-Villarejo J, Lobato-Márquez D, Díaz-Orejas R. López-Villarejo J, et al. Among authors: diaz orejas r. Toxins (Basel). 2015 Feb 5;7(2):478-92. doi: 10.3390/toxins7020478. Toxins (Basel). 2015. PMID: 25664511 Free PMC article.
Kis antitoxin couples plasmid R1 replication and parD (kis,kid) maintenance modules.
López-Villarejo J, Diago-Navarro E, Hernández-Arriaga AM, Díaz-Orejas R. López-Villarejo J, et al. Plasmid. 2012 Mar;67(2):118-27. doi: 10.1016/j.plasmid.2011.12.015. Epub 2012 Jan 8. Plasmid. 2012. PMID: 22244926
RNase/anti-RNase activities of the bacterial parD toxin-antitoxin system.
Muñoz-Gómez AJ, Lemonnier M, Santos-Sierra S, Berzal-Herranz A, Díaz-Orejas R. Muñoz-Gómez AJ, et al. J Bacteriol. 2005 May;187(9):3151-7. doi: 10.1128/JB.187.9.3151-3157.2005. J Bacteriol. 2005. PMID: 15838042 Free PMC article.
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