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A randomized double blind, placebo controlled phase 2 trial of BIIL 284 BS (an LTB4 receptor antagonist) for the treatment of lung disease in children and adults with cystic fibrosis.
Konstan MW, Döring G, Heltshe SL, Lands LC, Hilliard KA, Koker P, Bhattacharya S, Staab A, Hamilton A; Investigators and Coordinators of BI Trial 543.45. Konstan MW, et al. Among authors: doring g. J Cyst Fibros. 2014 Mar;13(2):148-55. doi: 10.1016/j.jcf.2013.12.009. Epub 2014 Jan 17. J Cyst Fibros. 2014. PMID: 24440167 Free PMC article. Clinical Trial.
Innate immunity in cystic fibrosis lung disease.
Hartl D, Gaggar A, Bruscia E, Hector A, Marcos V, Jung A, Greene C, McElvaney G, Mall M, Döring G. Hartl D, et al. Among authors: doring g. J Cyst Fibros. 2012 Sep;11(5):363-82. doi: 10.1016/j.jcf.2012.07.003. Epub 2012 Aug 20. J Cyst Fibros. 2012. PMID: 22917571 Review.
Lactate in cystic fibrosis sputum.
Bensel T, Stotz M, Borneff-Lipp M, Wollschläger B, Wienke A, Taccetti G, Campana S, Meyer KC, Jensen PØ, Lechner U, Ulrich M, Döring G, Worlitzsch D. Bensel T, et al. Among authors: doring g. J Cyst Fibros. 2011 Jan;10(1):37-44. doi: 10.1016/j.jcf.2010.09.004. Epub 2010 Oct 13. J Cyst Fibros. 2011. PMID: 20947455
Pseudomonas aeruginosa serology and risk for re-isolation in the EPIC trial.
Anstead M, Heltshe SL, Khan U, Barbieri JT, Langkamp M, Döring G, Dharia S, Gibson RL, Treggiari MM, Lymp J, Rosenfeld M, Ramsey B. Anstead M, et al. Among authors: doring g. J Cyst Fibros. 2013 Mar;12(2):147-53. doi: 10.1016/j.jcf.2012.08.001. Epub 2012 Sep 1. J Cyst Fibros. 2013. PMID: 22944725 Free PMC article. Clinical Trial.
BIIL 284 reduces neutrophil numbers but increases P. aeruginosa bacteremia and inflammation in mouse lungs.
Döring G, Bragonzi A, Paroni M, Aktürk FF, Cigana C, Schmidt A, Gilpin D, Heyder S, Born T, Smaczny C, Kohlhäufl M, Wagner TO, Loebinger MR, Bilton D, Tunney MM, Elborn JS, Pier GB, Konstan MW, Ulrich M. Döring G, et al. J Cyst Fibros. 2014 Mar;13(2):156-63. doi: 10.1016/j.jcf.2013.10.007. Epub 2013 Oct 31. J Cyst Fibros. 2014. PMID: 24183915 Free PMC article.
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