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Cellular senescence in cancer treatment: friend or foe?
Kahlem P, Dörken B, Schmitt CA. Kahlem P, et al. J Clin Invest. 2004 Jan;113(2):169-74. doi: 10.1172/JCI20784. J Clin Invest. 2004. PMID: 14722606 Free PMC article. Review.
Dynamic expression profile of p21WAF1/CIP1 and Ki-67 predicts survival in rectal carcinoma treated with preoperative radiochemotherapy.
Rau B, Sturm I, Lage H, Berger S, Schneider U, Hauptmann S, Wust P, Riess H, Schlag PM, Dörken B, Daniel PT. Rau B, et al. J Clin Oncol. 2003 Sep 15;21(18):3391-401. doi: 10.1200/JCO.2003.07.077. Epub 2003 Jul 28. J Clin Oncol. 2003. PMID: 12885834
Sorafenib, but not sunitinib, induces regulatory T cells in the peripheral blood of patients with metastatic renal cell carcinoma.
Flörcken A, Takvorian A, Van Lessen A, Singh A, Hopfenmüller W, Dörken B, Pezzutto A, Westermann J. Flörcken A, et al. Anticancer Drugs. 2012 Mar;23(3):298-302. doi: 10.1097/CAD.0b013e32834ee2b1. Anticancer Drugs. 2012. PMID: 22156795 Clinical Trial.
P53 overexpression and Ki67-index are associated with outcome in ductal pancreatic adenocarcinoma with adjuvant gemcitabine treatment.
Striefler JK, Sinn M, Pelzer U, Jühling A, Wislocka L, Bahra M, Sinn BV, Denkert C, Dörken B, Oettle H, Riess H, Bläker H, Lohneis P. Striefler JK, et al. Pathol Res Pract. 2016 Aug;212(8):726-34. doi: 10.1016/j.prp.2016.06.001. Epub 2016 Jun 8. Pathol Res Pract. 2016. PMID: 27461834
Silencing of APAF-1 in B-CLL results in poor prognosis in the case of concomitant p53 mutation.
Sturm I, Bosanquet AG, Radetzki S, Hummel M, Dörken B, Daniel PT. Sturm I, et al. Int J Cancer. 2006 May 1;118(9):2329-36. doi: 10.1002/ijc.21535. Int J Cancer. 2006. PMID: 16331630
Here, we aimed to study the impact of APAF-1 expression levels on cell death induced by anticancer drugs or ionizing irradiation (IR) and disease prognosis in B-type chronic lymphocytic leukemia (B-CLL) patients. Samples from 138 patients with B-CLL were inve …
Here, we aimed to study the impact of APAF-1 expression levels on cell death induced by anticancer drugs or ionizing irradiation (IR) and di …
Notch pathway inhibition controls myeloma bone disease in the murine MOPC315.BM model.
Schwarzer R, Nickel N, Godau J, Willie BM, Duda GN, Schwarzer R, Cirovic B, Leutz A, Manz R, Bogen B, Dörken B, Jundt F. Schwarzer R, et al. Blood Cancer J. 2014 Jun 13;4(6):e217. doi: 10.1038/bcj.2014.37. Blood Cancer J. 2014. PMID: 24927406 Free PMC article.
Bax expression in benign and malignant thyroid tumours: dysregulation of wild-type P53 is associated with a high Bax and P21 expression in thyroid carcinoma.
Hermann S, Sturm I, Mrozek A, Klosterhalfen B, Hauptmann S, Dörken B, Daniel PT. Hermann S, et al. Int J Cancer. 2001 Jun 15;92(6):805-11. doi: 10.1002/ijc.1284. Int J Cancer. 2001. PMID: 11351299
PI3-K/AKT/FKHR and MAPK signaling cascades are redundantly stimulated by a variety of cytokines and contribute independently to proliferation and survival of multiple myeloma cells.
Lentzsch S, Chatterjee M, Gries M, Bommert K, Gollasch H, Dörken B, Bargou RC. Lentzsch S, et al. Leukemia. 2004 Nov;18(11):1883-90. doi: 10.1038/sj.leu.2403486. Leukemia. 2004. PMID: 15356648
Loss of the tissue-specific proapoptotic BH3-only protein Nbk/Bik is a unifying feature of renal cell carcinoma.
Sturm I, Stephan C, Gillissen B, Siebert R, Janz M, Radetzki S, Jung K, Loening S, Dörken B, Daniel PT. Sturm I, et al. Cell Death Differ. 2006 Apr;13(4):619-27. doi: 10.1038/sj.cdd.4401782. Cell Death Differ. 2006. PMID: 16322756
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