Metabolic Effects of an SGLT2 Inhibitor (Dapagliflozin) During a Period of Acute Insulin Withdrawal and Development of Ketoacidosis in People With Type 1 Diabetes.
Herring RA, Shojaee-Moradie F, Garesse R, Stevenage M, Jackson N, Fielding BA, Mendis A, Johnsen S, Umpleby AM, Davies M, Russell-Jones DL.
Herring RA, et al. Among authors: russell jones dl.
Diabetes Care. 2020 Sep;43(9):2128-2136. doi: 10.2337/dc19-2579. Epub 2020 Jul 8.
Diabetes Care. 2020.
PMID: 32641376
Clinical Trial.
Participants received dapagliflozin or placebo in random order for 7 days. Stable isotopes were infused to measure the glucose R(a), R(d), and lipolysis. At isotopic steady state, insulin was withdrawn, and the study was terminated after 600 min or earlier if blood glucose …
Participants received dapagliflozin or placebo in random order for 7 days. Stable isotopes were infused to measure the glucose R(a), R(d …