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Year Number of Results
1997 1
1999 2
2002 4
2006 1
2009 3
2021 0
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Page 1
Intestinal drug absorption and metabolism in cell cultures: Caco-2 and beyond.
Artursson P, Borchardt RT. Artursson P, et al. Pharm Res. 1997 Dec;14(12):1655-8. doi: 10.1023/a:1012155124489. Pharm Res. 1997. PMID: 9453050 Review. No abstract available.
A comparison of the effects of p-glycoprotein inhibitors on the blood-brain barrier permeation of cyclic prodrugs of an opioid peptide (DADLE).
Ouyang H, Andersen TE, Chen W, Nofsinger R, Steffansen B, Borchardt RT. Ouyang H, et al. J Pharm Sci. 2009 Jun;98(6):2227-36. doi: 10.1002/jps.21585. J Pharm Sci. 2009. PMID: 18855917
Factors that restrict the intestinal cell permeation of cyclic prodrugs of an opioid peptide (DADLE): Part I. Role of efflux transporters in the intestinal mucosa.
Ouyang H, Chen W, Andersen TE, Steffansen B, Borchardt RT. Ouyang H, et al. J Pharm Sci. 2009 Jan;98(1):337-48. doi: 10.1002/jps.21428. J Pharm Sci. 2009. PMID: 18537149
Effects of amino acid chirality and the chemical linker on the cell permeation characteristics of cyclic prodrugs of opioid peptides.
Liederer BM, Fuchs T, Vander Velde D, Siahaan TJ, Borchardt RT. Liederer BM, et al. J Med Chem. 2006 Feb 23;49(4):1261-70. doi: 10.1021/jm050277f. J Med Chem. 2006. PMID: 16480263
In vitro stability and in vivo pharmacokinetic studies of a model opioid peptide, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (DADLE), and its cyclic prodrugs.
Yang JZ, Chen W, Borchardt RT. Yang JZ, et al. J Pharmacol Exp Ther. 2002 Nov;303(2):840-8. doi: 10.1124/jpet.102.037135. J Pharmacol Exp Ther. 2002. PMID: 12388671
Evaluation of the permeation characteristics of a model opioid peptide, H-Tyr-D-Ala-Gly-Phe-D-Leu-OH (DADLE), and its cyclic prodrugs across the blood-brain barrier using an in situ perfused rat brain model.
Chen W, Yang JZ, Andersen R, Nielsen LH, Borchardt RT. Chen W, et al. J Pharmacol Exp Ther. 2002 Nov;303(2):849-57. doi: 10.1124/jpet.102.037143. J Pharmacol Exp Ther. 2002. PMID: 12388672
Phenylpropionic acid-based cyclic prodrugs of opioid peptides that exhibit metabolic stability to peptidases and excellent cellular permeation.
Gudmundsson OS, Nimkar K, Gangwar S, Siahaan T, Borchardt RT. Gudmundsson OS, et al. Pharm Res. 1999 Jan;16(1):16-23. doi: 10.1023/a:1018802324759. Pharm Res. 1999. PMID: 9950273
Optimizing oral absorption of peptides using prodrug strategies.
Borchardt RT. Borchardt RT. J Control Release. 1999 Nov 1;62(1-2):231-8. doi: 10.1016/s0168-3659(99)00042-5. J Control Release. 1999. PMID: 10518655
A modified coumarinic acid-based cyclic prodrug of an opioid peptide: its enzymatic and chemical stability and cell permeation characteristics.
Ouyang H, Tang F, Siahaan TJ, Borchardt RT. Ouyang H, et al. Pharm Res. 2002 Jun;19(6):794-801. doi: 10.1023/a:1016148631055. Pharm Res. 2002. PMID: 12134949
Synthesis and conformational analysis of a coumarinic acid-based cyclic prodrug of an opioid peptide with modified sensitivity to esterase-catalyzed bioconversion.
Ouyang H, Vander Velde DG, Borchardt RT, Siahaan TJ. Ouyang H, et al. J Pept Res. 2002 Apr;59(4):183-95. doi: 10.1034/j.1399-3011.2002.1o983.x. J Pept Res. 2002. PMID: 11972752
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