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Bumetanide hyperpolarizes madin-darby canine kidney cells and enhances cellular gentamicin uptake by elevating cytosolic Ca(2+) thus facilitating intermediate conductance Ca(2+)--activated potassium channels.
Wang T, Yang YQ, Karasawa T, Wang Q, Phillips A, Guan BC, Ma KT, Jiang M, Xie DH, Steyger PS, Jiang ZG. Wang T, et al. Cell Biochem Biophys. 2013 Apr;65(3):381-98. doi: 10.1007/s12013-012-9442-2. Cell Biochem Biophys. 2013. PMID: 23109177 Free PMC article.