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Year Number of Results
1988 1
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1,635 results

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Page 1
The gasdermins, a protein family executing cell death and inflammation.
Broz P, Pelegrín P, Shao F. Broz P, et al. Nat Rev Immunol. 2020 Mar;20(3):143-157. doi: 10.1038/s41577-019-0228-2. Epub 2019 Nov 5. Nat Rev Immunol. 2020. PMID: 31690840 Review.
The gasdermins are a family of recently identified pore-forming effector proteins that cause membrane permeabilization and pyroptosis, a lytic pro-inflammatory type of cell death. Gasdermins contain a cytotoxic N-terminal domain and a C-terminal repressor …
The gasdermins are a family of recently identified pore-forming effector proteins that cause membrane permeabilization and pyroptosis …
DED or alive: assembly and regulation of the death effector domain complexes.
Riley JS, Malik A, Holohan C, Longley DB. Riley JS, et al. Cell Death Dis. 2015 Aug 27;6(8):e1866. doi: 10.1038/cddis.2015.213. Cell Death Dis. 2015. PMID: 26313917 Free PMC article. Review.
Death effector domains (DEDs) are protein-protein interaction domains initially identified in proteins such as FADD, FLIP and caspase-8 involved in regulating apoptosis. ...In this article, we review the various roles of DED-containing proteins and discuss re …
Death effector domains (DEDs) are protein-protein interaction domains initially identified in proteins such as FADD, FLIP and …
Neutrophils: Many Ways to Die.
Pérez-Figueroa E, Álvarez-Carrasco P, Ortega E, Maldonado-Bernal C. Pérez-Figueroa E, et al. Front Immunol. 2021 Mar 4;12:631821. doi: 10.3389/fimmu.2021.631821. eCollection 2021. Front Immunol. 2021. PMID: 33746968 Free PMC article. Review.
Currently, it has been realized that activated neutrophils can accomplish their effector functions and simultaneously activate mechanisms of cell death in response to different intracellular or extracellular factors. ...The effector functions are carried out …
Currently, it has been realized that activated neutrophils can accomplish their effector functions and simultaneously activate mechan …
Inflammasome signaling in colorectal cancer.
Sharma BR, Kanneganti TD. Sharma BR, et al. Transl Res. 2023 Feb;252:45-52. doi: 10.1016/j.trsl.2022.09.002. Epub 2022 Sep 21. Transl Res. 2023. PMID: 36150688 Free PMC article. Review.
The activation of some inflammasome sensors, including NLRP3, NLRP1, NLRP6, and Pyrin, provides protection from colitis-associated CRC via effector cytokine-dependent mechanisms. Additionally, activation of other inflammasome sensors, such as AIM2, NLRC4, and NAIPs, provid …
The activation of some inflammasome sensors, including NLRP3, NLRP1, NLRP6, and Pyrin, provides protection from colitis-associated CRC via …
Controlling Cell Death through Post-translational Modifications of DED Proteins.
Seyrek K, Ivanisenko NV, Richter M, Hillert LK, König C, Lavrik IN. Seyrek K, et al. Trends Cell Biol. 2020 May;30(5):354-369. doi: 10.1016/j.tcb.2020.02.006. Epub 2020 Mar 29. Trends Cell Biol. 2020. PMID: 32302548 Free article. Review.
The formation of a death-inducing signaling complex (DISC) and death effector domain (DED) filaments are critical for initiation of the extrinsic apoptotic pathway. ...In this review we discuss the influence of PTMs of FADD, procaspase-8, and c- …
The formation of a death-inducing signaling complex (DISC) and death effector domain (DED) filaments are …
Death domain fold proteins in immune signaling and transcriptional regulation.
Huoh YS, Hur S. Huoh YS, et al. FEBS J. 2022 Jul;289(14):4082-4097. doi: 10.1111/febs.15901. Epub 2021 May 13. FEBS J. 2022. PMID: 33905163 Free PMC article. Review.
Death domain fold (DDF) superfamily comprises of the death domain (DD), death effector domain (DED), caspase activation recruitment domain (CARD), and pyrin domain (PYD). ...
Death domain fold (DDF) superfamily comprises of the death domain (DD), death effector domain …
Death effector domain-containing proteins.
Valmiki MG, Ramos JW. Valmiki MG, et al. Cell Mol Life Sci. 2009 Mar;66(5):814-30. doi: 10.1007/s00018-008-8489-0. Cell Mol Life Sci. 2009. PMID: 18989622 Free PMC article. Review.
DEDs are a part of the larger family of Death Domain structures that have been primarily described in the control of programmed cell death. The seven standard DED-containing proteins are fas associated death domain protein (FADD), Caspase …
DEDs are a part of the larger family of Death Domain structures that have been primarily described in the control of programme …
Deciphering DED assembly mechanisms in FADD-procaspase-8-cFLIP complexes regulating apoptosis.
Yang CY, Lien CI, Tseng YC, Tu YF, Kulczyk AW, Lu YC, Wang YT, Su TW, Hsu LC, Lo YC, Lin SC. Yang CY, et al. Nat Commun. 2024 May 6;15(1):3791. doi: 10.1038/s41467-024-47990-2. Nat Commun. 2024. PMID: 38710704 Free PMC article.
Fas-associated protein with death domain (FADD), procaspase-8, and cellular FLICE-inhibitory proteins (cFLIP) assemble through death-effector domains (DEDs), directing death receptor signaling towards cell survival or apoptosis. ...These results …
Fas-associated protein with death domain (FADD), procaspase-8, and cellular FLICE-inhibitory proteins (cFLIP) assemble through …
TFOS Lifestyle: Impact of lifestyle challenges on the ocular surface.
Galor A, Britten-Jones AC, Feng Y, Ferrari G, Goldblum D, Gupta PK, Merayo-Lloves J, Na KS, Naroo SA, Nichols KK, Rocha EM, Tong L, Wang MTM, Craig JP. Galor A, et al. Ocul Surf. 2023 Apr;28:262-303. doi: 10.1016/j.jtos.2023.04.008. Epub 2023 Apr 11. Ocul Surf. 2023. PMID: 37054911
Sleep disorders (both involving quality and quantity of sleep) have also been associated with DED symptoms. Under the domain of physical health, several factors have been linked to meibomian gland abnormalities, including obesity and face mask wear. Cross-sectional …
Sleep disorders (both involving quality and quantity of sleep) have also been associated with DED symptoms. Under the domain o …
Mitochondria-targeted SkQ1 nanoparticles for dry eye disease: Inhibiting NLRP3 inflammasome activation by preventing mitochondrial DNA oxidation.
Huang B, Zhang N, Qiu X, Zeng R, Wang S, Hua M, Li Q, Nan K, Lin S. Huang B, et al. J Control Release. 2024 Jan;365:1-15. doi: 10.1016/j.jconrel.2023.11.021. Epub 2023 Nov 18. J Control Release. 2024. PMID: 37972763
NLRP3 is the key regulator for inducing ocular surface inflammation in DED. However, the mechanism by which ROS influences the bio-effects of NLRP3, and the consequent development of DED, largely remains elusive. ...Results suggested that SkQ1 NPs have great potenti …
NLRP3 is the key regulator for inducing ocular surface inflammation in DED. However, the mechanism by which ROS influences the bio-ef …
1,635 results