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Page 1
The RNA helicase DHX35 functions as a co-sensor for RIG-I-mediated innate immunity.
Qiao Y, Zhu S, Yang N, Zou SS, Gao B, Wu J, Liu C, Li X, Liu YJ, Chen J. Qiao Y, et al. PLoS Pathog. 2024 Jul 22;20(7):e1012379. doi: 10.1371/journal.ppat.1012379. eCollection 2024 Jul. PLoS Pathog. 2024. PMID: 39037956 Free PMC article.
DHX35 knockdown attenuated the production of interferon-beta (IFN-beta), IL6, and CXCL10, whereas DHX35 overexpression increased their production. ...Mitochondrial antiviral signaling protein (MAVS) acted as an adaptor for DHX35 and interacted with the HELICc …
DHX35 knockdown attenuated the production of interferon-beta (IFN-beta), IL6, and CXCL10, whereas DHX35 overexpression increas …
Identification of bicalutamide resistance-related genes and prognosis prediction in patients with prostate cancer.
Li Y, Wang H, Pan Y, Wang S, Zhang Z, Zhou H, Xu M, Liu X. Li Y, et al. Front Endocrinol (Lausanne). 2023 Apr 18;14:1125299. doi: 10.3389/fendo.2023.1125299. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37143720 Free PMC article.
BACKGROUND: Prostate cancer (PCa) is the second most common type of cancer and the fifth leading cause of cancer-related death in men. Androgen deprivation therapy (ADT) has become the first-line therapy for inhibiting PCa progression; however, nearly all pat …
BACKGROUND: Prostate cancer (PCa) is the second most common type of cancer and the fifth leading cause of cancer-relate …
Novel RNA variants in colorectal cancers.
Hoff AM, Johannessen B, Alagaratnam S, Zhao S, Nome T, Løvf M, Bakken AC, Hektoen M, Sveen A, Lothe RA, Skotheim RI. Hoff AM, et al. Oncotarget. 2015 Nov 3;6(34):36587-602. doi: 10.18632/oncotarget.5500. Oncotarget. 2015. PMID: 26474385 Free PMC article.
With an annual estimated incidence of 1.4 million, and a five-year survival rate of 60%, colorectal cancer (CRC) is a major clinical burden. To identify novel RNA variants in CRC, we analyzed exon-level microarray expression data from a cohort of 202 CRCs. ...RACE products …
With an annual estimated incidence of 1.4 million, and a five-year survival rate of 60%, colorectal cancer (CRC) is a major clinical …
Identification of epigenetic modifications mediating the antagonistic effect of selenium against cadmium-induced breast carcinogenesis.
Liang ZZ, Zhang YX, Zhu RM, Li YL, Jiang HM, Li RB, Chen QX, Wang Q, Tang LY, Ren ZF. Liang ZZ, et al. Environ Sci Pollut Res Int. 2022 Mar;29(15):22056-22068. doi: 10.1007/s11356-021-17355-z. Epub 2021 Nov 13. Environ Sci Pollut Res Int. 2022. PMID: 34773240
A total of 10 epigenetically regulated genes were regarded to mediate the antagonistic effect, including APBA2, KIAA0895, DHX35, CPEB3, SVIL, MYLK, ZFYVE28, ABLIM2, GRB10, and PCDH9. Biological function analyses suggested that these epigenetically regulated genes were invo …
A total of 10 epigenetically regulated genes were regarded to mediate the antagonistic effect, including APBA2, KIAA0895, DHX35, CPEB …
Genetically Determined Telomere Length Is Associated with Pancreatic Neuroendocrine Neoplasms Onset.
Gentiluomo M, Capurso G, Morelli L, Ermini S, Pasquali C, Latiano A, Tavano F, Greenhalf W, Milanetto AC, Landi S, Roth S, Malecka-Wojciesko E, Costello E, Jamroziak K, Perri F, Boggi U, Basso D, Farinati F, Kaaks R, Vanella G, Gais Zurcher AJ, Archibugi L, Lawlor RT, Canzian F, Campa D. Gentiluomo M, et al. Neuroendocrinology. 2022;112(12):1168-1176. doi: 10.1159/000524659. Epub 2022 Apr 26. Neuroendocrinology. 2022. PMID: 35472852
INTRODUCTION: Telomere length (TL) is a potential indicator of cancer predisposition; however, the multitude of techniques used to measure it causes the results to be heterogeneous and, in some cases, controversial. In the last years, several studies adopted a strategy bas …
INTRODUCTION: Telomere length (TL) is a potential indicator of cancer predisposition; however, the multitude of techniques used to me …
Novel genome-wide association study-based candidate loci for differentiated thyroid cancer risk.
Figlioli G, Köhler A, Chen B, Elisei R, Romei C, Cipollini M, Cristaudo A, Bambi F, Paolicchi E, Hoffmann P, Herms S, Kalemba M, Kula D, Pastor S, Marcos R, Velázquez A, Jarząb B, Landi S, Hemminki K, Försti A, Gemignani F. Figlioli G, et al. J Clin Endocrinol Metab. 2014 Oct;99(10):E2084-92. doi: 10.1210/jc.2014-1734. Epub 2014 Jul 16. J Clin Endocrinol Metab. 2014. PMID: 25029422
CONTEXT: Genome-wide association studies (GWASs) on differentiated thyroid cancer (DTC) have identified robust associations with single nucleotide polymorphisms (SNPs) at 9q22.33 (FOXE1), 14q13.3 (NKX2-1), and 2q35 (DIRC3). ...RESULTS: The combined analysis of the GWAS and …
CONTEXT: Genome-wide association studies (GWASs) on differentiated thyroid cancer (DTC) have identified robust associations with sing …
Genetic determinants of telomere length and risk of pancreatic cancer: A PANDoRA study.
Campa D, Matarazzi M, Greenhalf W, Bijlsma M, Saum KU, Pasquali C, van Laarhoven H, Szentesi A, Federici F, Vodicka P, Funel N, Pezzilli R, Bueno-de-Mesquita HB, Vodickova L, Basso D, Obazee O, Hackert T, Soucek P, Cuk K, Kaiser J, Sperti C, Lovecek M, Capurso G, Mohelnikova-Duchonova B, Khaw KT, König AK, Kupcinskas J, Kaaks R, Bambi F, Archibugi L, Mambrini A, Cavestro GM, Landi S, Hegyi P, Izbicki JR, Gioffreda D, Zambon CF, Tavano F, Talar-Wojnarowska R, Jamroziak K, Key TJ, Fave GD, Strobel O, Jonaitis L, Andriulli A, Lawlor RT, Pirozzi F, Katzke V, Valsuani C, Vashist YK, Brenner H, Canzian F. Campa D, et al. Int J Cancer. 2019 Mar 15;144(6):1275-1283. doi: 10.1002/ijc.31928. Epub 2018 Nov 12. Int J Cancer. 2019. PMID: 30325019
Telomere deregulation is a hallmark of cancer. Telomere length measured in lymphocytes (LTL) has been shown to be a risk marker for several cancers. ...In conclusion, we present a novel genome-wide candidate SNP for PDAC risk (TERT-rs2736100), a completely new signa …
Telomere deregulation is a hallmark of cancer. Telomere length measured in lymphocytes (LTL) has been shown to be a risk marker for s …
Identification of host DEAD-box RNA helicases that regulate cellular tropism of oncolytic Myxoma virus in human cancer cells.
Rahman MM, Bagdassarian E, Ali MAM, McFadden G. Rahman MM, et al. Sci Rep. 2017 Nov 16;7(1):15710. doi: 10.1038/s41598-017-15941-1. Sci Rep. 2017. PMID: 29146961 Free PMC article.
Myxoma virus (MYXV), a Leporipoxvirus, is being developed as an oncolytic virotherapeutic for the treatment of a variety of human cancers. MYXV tropism for human cancer cells is largely mediated by intracellular signaling networks that regulate viral replication or …
Myxoma virus (MYXV), a Leporipoxvirus, is being developed as an oncolytic virotherapeutic for the treatment of a variety of human cancers …
High Levels of DEAH-Box Helicases Relate to Poor Prognosis and Reduction of DHX9 Improves Radiosensitivity of Hepatocellular Carcinoma.
Chen X, Lin L, Chen G, Yan H, Li Z, Xiao M, He X, Zhang F, Zhang Y. Chen X, et al. Front Oncol. 2022 Jun 22;12:900671. doi: 10.3389/fonc.2022.900671. eCollection 2022. Front Oncol. 2022. PMID: 35814441 Free PMC article.
METHODS: The LIHC dataset was downloaded from The Cancer Genome Atlas (TCGA). Consensus clustering was applied to group the patients. Least absolute shrinkage and selection operator Cox regression and univariate and multivariate Cox regression were used to develop and vali …
METHODS: The LIHC dataset was downloaded from The Cancer Genome Atlas (TCGA). Consensus clustering was applied to group the patients. …
The Contribution of Genetic Variants to the Risk of Papillary Thyroid Carcinoma in the Kazakh Population: Study of Common Single Nucleotide Polymorphisms and Their Clinicopathological Correlations.
Mussazhanova Z, Rogounovitch TI, Saenko VA, Krykpayeva A, Espenbetova M, Azizov B, Kondo H, Matsuda K, Kalmatayeva Z, Issayeva R, Yeleubayeva Z, Madiyeva M, Mukanova A, Sandybayev M, Bolsynbekova S, Kozykenova Z, Yamashita S, Nakashima M. Mussazhanova Z, et al. Front Endocrinol (Lausanne). 2021 Jan 22;11:543500. doi: 10.3389/fendo.2020.543500. eCollection 2020. Front Endocrinol (Lausanne). 2021. PMID: 33551988 Free PMC article.
Recent progress in the genome-wide association studies of thyroid cancer leads to the identification of several genetic variants conferring risk to this malignancy across different ethnicities. ...RESULT: Five of the eight SNPs: rs965513 (FOXE1/PTCSC2, P = 1.3E-16), rs1867 …
Recent progress in the genome-wide association studies of thyroid cancer leads to the identification of several genetic variants conf …