Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 1
2003 1
2004 3
2005 1
2006 1
2007 1
2008 4
2009 6
2010 4
2011 3
2012 3
2013 10
2014 5
2015 6
2016 6
2017 5
2018 5
2019 10
2020 7
2021 7
2022 8
2023 6
2024 8
2025 5

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

103 results

Results by year

Filters applied: . Clear all
Page 1
DIAPH1 facilitates paclitaxel-mediated cytotoxicity of ovarian cancer cells.
Flat W, Borowski S, Paraschiakos T, Blechner C, Windhorst S. Flat W, et al. Biochem Pharmacol. 2022 Mar;197:114898. doi: 10.1016/j.bcp.2021.114898. Epub 2021 Dec 27. Biochem Pharmacol. 2022. PMID: 34968485
Also, the activated formin Diaphanous Related Formin 1 (DIAPH1) binds to MTs and increases its stability. In a recent study, we found that high DIAPH1 levels correlated with increased survival of ovarian cancer (Ovca) patients. ...In vitro analysis with recom …
Also, the activated formin Diaphanous Related Formin 1 (DIAPH1) binds to MTs and increases its stability. In a recent study, we found …
DIAPH1 regulates chromosomal instability of cancer cells by controlling microtubule dynamics.
Miao S, Schäfer P, Nojszewski J, Meyer F, Windhorst S. Miao S, et al. Eur J Cell Biol. 2021 Apr;100(3):151156. doi: 10.1016/j.ejcb.2021.151156. Epub 2021 Mar 1. Eur J Cell Biol. 2021. PMID: 33689956 Free article.
Diaphanous Related Formin 1 (DIAPH1) is an actin nucleator and also binds microtubule (MT) with high affinity. In this study, we analyzed the role of DIAPH1 in regulation of spindle MT-dynamics and CIN in HT29 and HCT-116 colorectal cancer (CRC) cells. ...Sin …
Diaphanous Related Formin 1 (DIAPH1) is an actin nucleator and also binds microtubule (MT) with high affinity. In this study, we anal …
DIAPH1 mediates progression of atherosclerosis and regulates hepatic lipid metabolism in mice.
Senatus L, Egaña-Gorroño L, López-Díez R, Bergaya S, Aranda JF, Amengual J, Arivazhagan L, Manigrasso MB, Yepuri G, Nimma R, Mangar KN, Bernadin R, Zhou B, Gugger PF, Li H, Friedman RA, Theise ND, Shekhtman A, Fisher EA, Ramasamy R, Schmidt AM. Senatus L, et al. Commun Biol. 2023 Mar 17;6(1):280. doi: 10.1038/s42003-023-04643-2. Commun Biol. 2023. PMID: 36932214 Free PMC article.
We intercrossed atherosclerosis-prone Ldlr(-/-) mice with mice devoid of Diaph1 and fed them Western diet for 16 weeks. Compared to male Ldlr(-/-) mice, male Ldlr(-/-) Diaph1(-/-) mice displayed significantly less atherosclerosis, in parallel with lower plasma conce …
We intercrossed atherosclerosis-prone Ldlr(-/-) mice with mice devoid of Diaph1 and fed them Western diet for 16 weeks. Compared to m …
DIAPH1 mutations predict a favorable outcome for de novo MDS.
Tang Y, Wang H, Zhang Z, Yao Y, Han Y, Wu D. Tang Y, et al. Cancer Lett. 2024 Aug 28;598:217125. doi: 10.1016/j.canlet.2024.217125. Epub 2024 Jul 30. Cancer Lett. 2024. PMID: 39084456
The megakaryopoiesis-related genes: GP1BA and SETBP1 mutation were positively and negatively associated with DIAPH1 mutation, respectively. DIAPH1 mutated cases showed superior overall survival of all patients and low-risk cohorts. In conclusion, we found DIAPH1 …
The megakaryopoiesis-related genes: GP1BA and SETBP1 mutation were positively and negatively associated with DIAPH1 mutation, respect …
WTAP-mediated m(6)A modification of lncRNA DIAPH1-AS1 enhances its stability to facilitate nasopharyngeal carcinoma growth and metastasis.
Li ZX, Zheng ZQ, Yang PY, Lin L, Zhou GQ, Lv JW, Zhang LL, Chen F, Li YQ, Wu CF, Li F, Ma J, Liu N, Sun Y. Li ZX, et al. Cell Death Differ. 2022 Jun;29(6):1137-1151. doi: 10.1038/s41418-021-00905-w. Epub 2022 Jan 8. Cell Death Differ. 2022. PMID: 34999731 Free PMC article.
Functionally, WTAP was required for the growth and metastasis of NPC. Mechanistically, lncRNA DIAPH1-AS1 was identified as a bona fide m(6)A target of WTAP. WTAP-mediated m(6)A modification of DIAPH1-AS1 enhanced its stability relying on the m(6)A reader IGF2BP2-dep …
Functionally, WTAP was required for the growth and metastasis of NPC. Mechanistically, lncRNA DIAPH1-AS1 was identified as a bona fid …
Expression of DIAPH1 is up-regulated in colorectal cancer and its down-regulation strongly reduces the metastatic capacity of colon carcinoma cells.
Lin YN, Izbicki JR, König A, Habermann JK, Blechner C, Lange T, Schumacher U, Windhorst S. Lin YN, et al. Int J Cancer. 2014 Apr 1;134(7):1571-82. doi: 10.1002/ijc.28486. Epub 2013 Oct 8. Int J Cancer. 2014. PMID: 24105619
Here we analyzed expression of the ABPs, DIAPH1, VASP, N-WASP, and fascin in comparison with cortactin and found that, besides cortactin, DIAPH1 was expressed with the highest frequency (63%) in colorectal cancer. As well as cortactin, DIAPH1 was not d …
Here we analyzed expression of the ABPs, DIAPH1, VASP, N-WASP, and fascin in comparison with cortactin and found that, besides cortac …
Drosophila homologue of Diaphanous 1 (DIAPH1) controls the metastatic potential of colon cancer cells by regulating microtubule-dependent adhesion.
Lin YN, Bhuwania R, Gromova K, Failla AV, Lange T, Riecken K, Linder S, Kneussel M, Izbicki JR, Windhorst S. Lin YN, et al. Oncotarget. 2015 Jul 30;6(21):18577-89. doi: 10.18632/oncotarget.4094. Oncotarget. 2015. PMID: 26124177 Free PMC article.
Recently, we showed strongly reduced lung metastasis of DIAPH1-depleted colon cancer cells but we found accumulations of DIAPH1-depleted cells in bone marrow. ...Thus, blockade of DIAPH1-tubulin interaction may be a promising approach to inhibit one of …
Recently, we showed strongly reduced lung metastasis of DIAPH1-depleted colon cancer cells but we found accumulations of DI …
CREB1-induced lncRNA LEF1-AS1 contributes to colorectal cancer progression via the miR-489/DIAPH1 axis.
Cheng Y, Wu J, Qin B, Zou BC, Wang YH, Li Y. Cheng Y, et al. Biochem Biophys Res Commun. 2020 Jun 4;526(3):678-684. doi: 10.1016/j.bbrc.2020.03.153. Epub 2020 Apr 2. Biochem Biophys Res Commun. 2020. PMID: 32248974
This research aimed to investigate the roles and mechanisms of LEF1-AS1 in colorectal cancer (CRC). We firstly showed that LEF1-AS1 expression was upregulated in human CRC tissues and cell lines. ...Mechanically, LEF1-AS1 functioned as competing endogenous RNA (ceRNA) for …
This research aimed to investigate the roles and mechanisms of LEF1-AS1 in colorectal cancer (CRC). We firstly showed that LEF1-AS1 e …
Formin protein DIAPH1 positively regulates PD-L1 expression and predicts the therapeutic response to anti-PD-1/PD-L1 immunotherapy.
Mei J, Cai Y, Wang H, Xu R, Zhou J, Lu J, Yang X, Pan J, Liu C, Xu J, Zhu Y. Mei J, et al. Clin Immunol. 2023 Jan;246:109204. doi: 10.1016/j.clim.2022.109204. Epub 2022 Dec 8. Clin Immunol. 2023. PMID: 36503156
Formins are evolutionarily conserved genes and profoundly affect cancer progression. This study aims to explore the expressions, prognostic values, and immunological correlations of Formins in cancer. ...Moreover, DIAPH1 was overexpressed in most cancers …
Formins are evolutionarily conserved genes and profoundly affect cancer progression. This study aims to explore the expressions, prog …
DIAPH1 Promotes Laryngeal Squamous Cell Carcinoma Progression Through Cell Cycle Regulation.
Yang J, Huang Q, Guo Y, Wei Z, Zhou L, Chen H. Yang J, et al. Front Oncol. 2021 Sep 22;11:716876. doi: 10.3389/fonc.2021.716876. eCollection 2021. Front Oncol. 2021. PMID: 34631544 Free PMC article.
Cell cycle disorders are generally regarded as important underlying causes of many cancers. In the current study, we have revealed that DIAPH1 expression is an independent prognostic factor for overall survival in patients with laryngeal squamous cell carcinoma (LSC …
Cell cycle disorders are generally regarded as important underlying causes of many cancers. In the current study, we have revealed th …
103 results