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3,903 results

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Page 1
Drug induced liver injury - a 2023 update.
Allison R, Guraka A, Shawa IT, Tripathi G, Moritz W, Kermanizadeh A. Allison R, et al. J Toxicol Environ Health B Crit Rev. 2023 Nov 17;26(8):442-467. doi: 10.1080/10937404.2023.2261848. Epub 2023 Oct 19. J Toxicol Environ Health B Crit Rev. 2023. PMID: 37786264 Free article. Review.
Drug-Induced Liver Injury (DILI) constitutes hepatic damage attributed to drug exposure. DILI may be categorized as hepatocellular, cholestatic or mixed and might also involve immune responses. ...This review considers (1) what is currently known regarding the mecha …
Drug-Induced Liver Injury (DILI) constitutes hepatic damage attributed to drug exposure. DILI may be categorized as hepatocell …
Drug-induced liver injury: a comprehensive review.
Hosack T, Damry D, Biswas S. Hosack T, et al. Ther Adv Gastroenterol. 2023 Mar 21;16:17562848231163410. doi: 10.1177/17562848231163410. eCollection 2023. Ther Adv Gastroenterol. 2023. PMID: 36968618 Free PMC article. Review.
Drug-induced liver injury (DILI) remains a challenge in clinical practice and is still a diagnosis of exclusion. ...While multiple mechanisms of DILI have been postulated, there is no clear causal relationship between drugs, risk factors and mechanisms of DILI …
Drug-induced liver injury (DILI) remains a challenge in clinical practice and is still a diagnosis of exclusion. ...While multiple me …
The Promise of AI for DILI Prediction.
Vall A, Sabnis Y, Shi J, Class R, Hochreiter S, Klambauer G. Vall A, et al. Front Artif Intell. 2021 Apr 14;4:638410. doi: 10.3389/frai.2021.638410. eCollection 2021. Front Artif Intell. 2021. PMID: 33937745 Free PMC article. Review.
Drug-induced liver injury (DILI) is a common reason for the withdrawal of a drug from the market. Early assessment of DILI risk is an essential part of drug development, but it is rendered challenging prior to clinical trials by the complex factors that give rise to …
Drug-induced liver injury (DILI) is a common reason for the withdrawal of a drug from the market. Early assessment of DILI ris …
Drug-induced liver injury: Pathogenesis, epidemiology, clinical features, and practical management.
Björnsson HK, Björnsson ES. Björnsson HK, et al. Eur J Intern Med. 2022 Mar;97:26-31. doi: 10.1016/j.ejim.2021.10.035. Epub 2021 Nov 9. Eur J Intern Med. 2022. PMID: 34772600 Review.
Associations of HLA genotypes and risk of DILI have highlighted the importance of the immune system in the pathogenesis of DILI. ...Thanks to multicenter prospective studies on DILI and websites in the public domain such as LiverTox, physicians are provided w …
Associations of HLA genotypes and risk of DILI have highlighted the importance of the immune system in the pathogenesis of DILI …
ACG Clinical Guideline: Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury.
Chalasani NP, Maddur H, Russo MW, Wong RJ, Reddy KR; Practice Parameters Committee of the American College of Gastroenterology. Chalasani NP, et al. Am J Gastroenterol. 2021 May 1;116(5):878-898. doi: 10.14309/ajg.0000000000001259. Am J Gastroenterol. 2021. PMID: 33929376
Antimicrobials, herbal and dietary supplements, and anticancer therapeutics (e.g., tyrosine kinase inhibitors or immune-checkpoint inhibitors) are the most common classes of agents to cause DILI in the Western world. DILI is a diagnosis of exclusion, and thus, caref …
Antimicrobials, herbal and dietary supplements, and anticancer therapeutics (e.g., tyrosine kinase inhibitors or immune-checkpoint inhibitor …
Drug-induced liver injury.
Katarey D, Verma S. Katarey D, et al. Clin Med (Lond). 2016 Dec;16(Suppl 6):s104-s109. doi: 10.7861/clinmedicine.16-6-s104. Clin Med (Lond). 2016. PMID: 27956449 Free PMC article. Review.
Drug-induced liver injury (DILI) remains the most common cause of acute liver failure (ALF) in the western world. ...In view of the poor transplant-free survival in idiosyncratic DILI, early consideration for liver transplant is mandatory....
Drug-induced liver injury (DILI) remains the most common cause of acute liver failure (ALF) in the western world. ...In view of the p …
Incidence and risk factors of drug-induced liver injury.
Li X, Tang J, Mao Y. Li X, et al. Liver Int. 2022 Aug;42(9):1999-2014. doi: 10.1111/liv.15262. Epub 2022 Apr 2. Liver Int. 2022. PMID: 35353431 Review.
In addition, drugs implicated in DILI differ between Western and Eastern countries. Antibiotics are the leading drugs implicated in DILI in the West, whereas traditional Chinese medicine is the primary cause implicated in DILI in the East. ...Several genetic …
In addition, drugs implicated in DILI differ between Western and Eastern countries. Antibiotics are the leading drugs implicated in …
Idiosyncratic DILI: Analysis of 46,266 Cases Assessed for Causality by RUCAM and Published From 2014 to Early 2019.
Teschke R. Teschke R. Front Pharmacol. 2019 Jul 23;10:730. doi: 10.3389/fphar.2019.00730. eCollection 2019. Front Pharmacol. 2019. PMID: 31396080 Free PMC article. Review.
RUCAM (Roussel Uclaf Causality Assessment Method) is a well-established diagnostic algorithm and scale to assess causality in patients with suspected DILI. First published in 1993 and updated in 2016, RUCAM is now the worldwide most commonly used causality assessment metho …
RUCAM (Roussel Uclaf Causality Assessment Method) is a well-established diagnostic algorithm and scale to assess causality in patients with …
Risk factors and prediction for DILI in clinical practice.
Björnsson HK, Björnsson ES. Björnsson HK, et al. Expert Opin Drug Metab Toxicol. 2025 May;21(5):579-587. doi: 10.1080/17425255.2025.2468200. Epub 2025 Feb 23. Expert Opin Drug Metab Toxicol. 2025. PMID: 39957436 Review.
The risk stratification of patients susceptible to DILI is a growing field. AREAS COVERED: The current article highlights new studies on risk stratification regarding risk factors of DILI, prediction of liver injury, and predictors of severe outcomes. Studies on pat …
The risk stratification of patients susceptible to DILI is a growing field. AREAS COVERED: The current article highlights new studies …
Case definition and phenotype standardization in drug-induced liver injury.
Aithal GP, Watkins PB, Andrade RJ, Larrey D, Molokhia M, Takikawa H, Hunt CM, Wilke RA, Avigan M, Kaplowitz N, Bjornsson E, Daly AK. Aithal GP, et al. Clin Pharmacol Ther. 2011 Jun;89(6):806-15. doi: 10.1038/clpt.2011.58. Epub 2011 May 4. Clin Pharmacol Ther. 2011. PMID: 21544079 Review.
Investigators around the globe have begun to identify and study patients with DILI; several large registries and tissue banks are being established. In order to gain the maximum scientific benefit from these efforts, the definitions and terminology related to the clinical …
Investigators around the globe have begun to identify and study patients with DILI; several large registries and tissue banks are bei …
3,903 results