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97 results

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Page 1
Effect of DIO2 Gene Polymorphism on Thyroid Hormone Levels and Its Correlation with the Severity of Schizophrenia in a Pakistani Population.
Hanif F, Amir Q, Washdev W. Hanif F, et al. Int J Mol Sci. 2024 Feb 5;25(3):1915. doi: 10.3390/ijms25031915. Int J Mol Sci. 2024. PMID: 38339190 Free PMC article.
Low levels of triiodothyronine (T3) in the brain lead to increased dopamine receptor sensitivity, potentially resulting in schizophrenia. Iodothyronine deiodinase 2 (DIO2) is the only enzyme which converts tetraiodothyronine (T4) to T3 in the brain. DIO2 polymorp …
Low levels of triiodothyronine (T3) in the brain lead to increased dopamine receptor sensitivity, potentially resulting in schizophrenia. Io …
Comparative Effectiveness of Levothyroxine, Desiccated Thyroid Extract, and Levothyroxine+Liothyronine in Hypothyroidism.
Shakir MKM, Brooks DI, McAninch EA, Fonseca TL, Mai VQ, Bianco AC, Hoang TD. Shakir MKM, et al. J Clin Endocrinol Metab. 2021 Oct 21;106(11):e4400-e4413. doi: 10.1210/clinem/dgab478. J Clin Endocrinol Metab. 2021. PMID: 34185829 Free PMC article. Clinical Trial.
Secondary endpoints included treatment preference, biochemical and metabolic parameters, etiology of hypothyroidism, and Thr92Ala-DIO2 gene polymorphism. Analyses were performed with a linear mixed model using subject as a random factor and group as a fixed effect. …
Secondary endpoints included treatment preference, biochemical and metabolic parameters, etiology of hypothyroidism, and Thr92Ala-DIO2 …
Prevalence of Dio2(T92A) polymorphism and its association with thyroid autoimmunity.
Guerra A, Sapio MR, Carrano M, Di Stasi V, Volpe A, Murino A, Izzo G, Vitale M. Guerra A, et al. J Endocrinol Invest. 2013 May;36(5):303-6. doi: 10.3275/8618. Epub 2012 Sep 24. J Endocrinol Invest. 2013. PMID: 23013882
Because thyroid hormones can modulate the immune response, we hypothesized a pathophysiological role for Dio(2T92A) polymorphism in autoimmunity. The objective of this study was to investigate the Dio(2T92A) polymorphism in relation to thyroid autoimmu …
Because thyroid hormones can modulate the immune response, we hypothesized a pathophysiological role for Dio(2T92A) polymorphism …
FVB But Not B6 Mice Carrying the Thr92Ala-Dio2 Polymorphism Have Impaired Thyroid Hormonogenesis and Goiter.
Batistuzzo A, Zhang X, Bocco BMLC, McAninch EA, Salas-Lucia F, Ribeiro MO, Arvan P, Bianco AC, Fonseca TL. Batistuzzo A, et al. Endocrinology. 2025 Mar 24;166(5):bqaf046. doi: 10.1210/endocr/bqaf046. Endocrinology. 2025. PMID: 40085762 Free PMC article.
To understand why its phenotypic effects are variable across different populations, in this study we examined the impact of genetic background on the Thr92Ala-Dio2 polymorphism. We focused on the thyroid gland of 2 genetically distant mouse stra …
To understand why its phenotypic effects are variable across different populations, in this study we examined the impact of genetic b …
Concurrent TSHR mutations and DIO2 T92A polymorphism result in abnormal thyroid hormone metabolism.
Park E, Jung J, Araki O, Tsunekawa K, Park SY, Kim J, Murakami M, Jeong SY, Lee S. Park E, et al. Sci Rep. 2018 Jul 4;8(1):10090. doi: 10.1038/s41598-018-28480-0. Sci Rep. 2018. PMID: 29973617 Free PMC article.
Deiodinase 2 (DIO2) plays an important role in thyroid hormone metabolism and its regulation. However, molecular mechanism that regulates DIO2 activity remains unclear; only mutaions in selenocysteine insertion sequence binding protein 2 and selenocysteine tr …
Deiodinase 2 (DIO2) plays an important role in thyroid hormone metabolism and its regulation. However, molecular mechanism tha …
A study of the role of DIO1 and DIO2 polymorphism in thyroid cancer and drug response to therapy in the Saudi population.
AlRasheed MM, AlAnzi A, AlShalhoub R, Abanmy N, Bakheet D. AlRasheed MM, et al. Saudi Pharm J. 2019 Sep;27(6):841-845. doi: 10.1016/j.jsps.2019.05.005. Epub 2019 May 21. Saudi Pharm J. 2019. PMID: 31516326 Free PMC article.
The role of the deiodinase (DIO) gene polymorphisms in thyroid cancer is not fully understood yet. This study evaluated the potential association of the DIO1 and DIO2 genes with differentiated thyroid cancer and differential thyroxine dose requirement …
The role of the deiodinase (DIO) gene polymorphisms in thyroid cancer is not fully understood yet. This study evaluated the po …
Association between DIO2 Thr92Ala polymorphism and hypertension in patients with hypothyroidism: Korean Genome and Epidemiology Study.
Kang YM, Koo BS, Yi HS, Kim JT, Park B, Lee JH, Shong M, Kang YE. Kang YM, et al. Korean J Intern Med. 2023 Mar;38(2):226-237. doi: 10.3904/kjim.2022.292. Epub 2023 Jan 17. Korean J Intern Med. 2023. PMID: 36646987 Free PMC article.
BACKGROUND/AIMS: Recent evidence has identified the significance of type 2 iodothyronine deiodinase (DIO2) in various diseases. However, the role of DIO2 polymorphism in metabolic parameters in patients with hypothyroidism is not fully understood. ...Our resu …
BACKGROUND/AIMS: Recent evidence has identified the significance of type 2 iodothyronine deiodinase (DIO2) in various diseases. Howev …
Pathophysiological relevance of deiodinase polymorphism.
Bianco AC, Kim BS. Bianco AC, et al. Curr Opin Endocrinol Diabetes Obes. 2018 Oct;25(5):341-346. doi: 10.1097/MED.0000000000000428. Curr Opin Endocrinol Diabetes Obes. 2018. PMID: 30063552 Free PMC article. Review.
RECENT FINDINGS: A new report indicates that carriers of the Thr92Ala-DIO2 polymorphism exhibit lower D2 catalytic activity and localized/systemic hypothyroidism. ...Future studies should explore how the racial background modulates the clinical relevance of the Thr9 …
RECENT FINDINGS: A new report indicates that carriers of the Thr92Ala-DIO2 polymorphism exhibit lower D2 catalytic activity an …
A Common DIO2 Polymorphism and Alzheimer Disease Dementia in African and European Americans.
McAninch EA, Rajan KB, Evans DA, Jo S, Chaker L, Peeters RP, Bennett DA, Mash DC, Bianco AC. McAninch EA, et al. J Clin Endocrinol Metab. 2018 May 1;103(5):1818-1826. doi: 10.1210/jc.2017-01196. J Clin Endocrinol Metab. 2018. PMID: 29481662 Free PMC article.
CONTEXT: A common single nucleotide polymorphism in DIO2, Thr92AlaD2, has been associated with a transcriptome typically found in neurodegenerative diseases in postmortem human brain tissue. ...
CONTEXT: A common single nucleotide polymorphism in DIO2, Thr92AlaD2, has been associated with a transcriptome typically found …
Association between DIO2 polymorphism and the risk of Kashin-Beck disease in the Tibetan population.
Jin T, Wang L, He X, Liu M, Bai M, Rong H, He Y, Yuan D. Jin T, et al. J Gene Med. 2019 Oct;21(10):e3123. doi: 10.1002/jgm.3123. Epub 2019 Sep 4. J Gene Med. 2019. PMID: 31433532
Seven single nucleotide polymorphisms in DIO2 were selected and genotyped using the Agena MassARRAY platform (Agena Bioscience, San Diego, CA, USA). ...CONCLUSIONS: The results obtained in the present study indicate that DIO2 polymorphisms rs1352815 an …
Seven single nucleotide polymorphisms in DIO2 were selected and genotyped using the Agena MassARRAY platform (Agena Bioscience …
97 results