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AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC.
Sajan MP, Bandyopadhyay G, Miura A, Standaert ML, Nimal S, Longnus SL, Van Obberghen E, Hainault I, Foufelle F, Kahn R, Braun U, Leitges M, Farese RV. Sajan MP, et al. Am J Physiol Endocrinol Metab. 2010 Feb;298(2):E179-92. doi: 10.1152/ajpendo.00392.2009. Epub 2009 Nov 3. Am J Physiol Endocrinol Metab. 2010. PMID: 19887597 Free PMC article.
Role of atypical protein kinase C in activation of sterol regulatory element binding protein-1c and nuclear factor kappa B (NFkappaB) in liver of rodents used as a model of diabetes, and relationships to hyperlipidaemia and insulin resistance.
Sajan MP, Standaert ML, Rivas J, Miura A, Kanoh Y, Soto J, Taniguchi CM, Kahn CR, Farese RV. Sajan MP, et al. Diabetologia. 2009 Jun;52(6):1197-207. doi: 10.1007/s00125-009-1336-5. Epub 2009 Apr 9. Diabetologia. 2009. PMID: 19357831 Free PMC article.