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Page 1
Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway.
Arroyo JP, Lagnaz D, Ronzaud C, Vázquez N, Ko BS, Moddes L, Ruffieux-Daidié D, Hausel P, Koesters R, Yang B, Stokes JB, Hoover RS, Gamba G, Staub O. Arroyo JP, et al. J Am Soc Nephrol. 2011 Sep;22(9):1707-19. doi: 10.1681/ASN.2011020132. Epub 2011 Aug 18. J Am Soc Nephrol. 2011. PMID: 21852580 Free PMC article.
WNK4 kinase is a negative regulator of K+-Cl- cotransporters.
Garzón-Muvdi T, Pacheco-Alvarez D, Gagnon KB, Vázquez N, Ponce-Coria J, Moreno E, Delpire E, Gamba G. Garzón-Muvdi T, et al. Am J Physiol Renal Physiol. 2007 Apr;292(4):F1197-207. doi: 10.1152/ajprenal.00335.2006. Epub 2006 Dec 19. Am J Physiol Renal Physiol. 2007. PMID: 17182532 Free article.
Regulation of NKCC2 by a chloride-sensing mechanism involving the WNK3 and SPAK kinases.
Ponce-Coria J, San-Cristobal P, Kahle KT, Vazquez N, Pacheco-Alvarez D, de Los Heros P, Juárez P, Muñoz E, Michel G, Bobadilla NA, Gimenez I, Lifton RP, Hebert SC, Gamba G. Ponce-Coria J, et al. Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8458-63. doi: 10.1073/pnas.0802966105. Epub 2008 Jun 11. Proc Natl Acad Sci U S A. 2008. PMID: 18550832 Free PMC article.
Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway.
San-Cristobal P, Pacheco-Alvarez D, Richardson C, Ring AM, Vazquez N, Rafiqi FH, Chari D, Kahle KT, Leng Q, Bobadilla NA, Hebert SC, Alessi DR, Lifton RP, Gamba G. San-Cristobal P, et al. Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4384-9. doi: 10.1073/pnas.0813238106. Epub 2009 Feb 24. Proc Natl Acad Sci U S A. 2009. PMID: 19240212 Free PMC article.
16 results