Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2000 1
2003 1
2004 3
2005 1
2006 4
2007 3
2008 4
2009 10
2010 3
2011 12
2012 8
2013 8
2014 14
2015 15
2016 13
2017 19
2018 23
2019 13
2020 14
2021 18
2022 11
2023 11
2024 12
2025 5

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

200 results

Results by year

Filters applied: . Clear all
Page 1
Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages.
Mandula JK, Sierra-Mondragon RA, Jimenez RV, Chang D, Mohamed E, Chang S, Vazquez-Martinez JA, Cao Y, Anadon CM, Lee SB, Das S, Rocha-Munguba L, Pham VM, Li R, Tarhini AA, Furqan M, Dalton W, Churchman M, Moran-Segura CM, Nguyen J, Perez B, Kojetin DJ, Obermayer A, Yu X, Chen A, Shaw TI, Conejo-Garcia JR, Rodriguez PC. Mandula JK, et al. Immunity. 2024 May 14;57(5):1124-1140.e9. doi: 10.1016/j.immuni.2024.03.020. Epub 2024 Apr 17. Immunity. 2024. PMID: 38636522 Free PMC article.
In NSCLC pre-clinical models, deletion of Jag2, but not Jag1, in cancer cells attenuated tumor growth and activated protective anti-tumor T cell responses. ...Mechanistically, Jag2 ablation promoted Nr4a-mediated induction of Notch ligands DLL1/4 on cancer ce …
In NSCLC pre-clinical models, deletion of Jag2, but not Jag1, in cancer cells attenuated tumor growth and activated protective anti-t …
Estrogen-dependent DLL1-mediated Notch signaling promotes luminal breast cancer.
Kumar S, Srivastav RK, Wilkes DW, Ross T, Kim S, Kowalski J, Chatla S, Zhang Q, Nayak A, Guha M, Fuchs SY, Thomas C, Chakrabarti R. Kumar S, et al. Oncogene. 2019 Mar;38(12):2092-2107. doi: 10.1038/s41388-018-0562-z. Epub 2018 Nov 15. Oncogene. 2019. PMID: 30442981 Free PMC article.
Intriguingly, DLL1 overexpression correlates with poor prognosis in ERalpha(+) luminal breast cancer, but not in other subtypes of breast cancer. ...Consistent with prognostic clinical data, we found the tumor-promoting function of DLL1 is exclusive to …
Intriguingly, DLL1 overexpression correlates with poor prognosis in ERalpha(+) luminal breast cancer, but not in other subtype …
The bone marrow microenvironment at single-cell resolution.
Tikhonova AN, Dolgalev I, Hu H, Sivaraj KK, Hoxha E, Cuesta-Domínguez Á, Pinho S, Akhmetzyanova I, Gao J, Witkowski M, Guillamot M, Gutkin MC, Zhang Y, Marier C, Diefenbach C, Kousteni S, Heguy A, Zhong H, Fooksman DR, Butler JM, Economides A, Frenette PS, Adams RH, Satija R, Tsirigos A, Aifantis I. Tikhonova AN, et al. Nature. 2019 May;569(7755):222-228. doi: 10.1038/s41586-019-1104-8. Epub 2019 Apr 10. Nature. 2019. PMID: 30971824 Free PMC article.
Among the stress-induced changes, we observed that vascular Notch delta-like ligands (encoded by Dll1 and Dll4) were downregulated. In the absence of vascular Dll4, haematopoietic stem cells prematurely induced a myeloid transcriptional program. ...
Among the stress-induced changes, we observed that vascular Notch delta-like ligands (encoded by Dll1 and Dll4) were downregulated. I …
Dll1(+) quiescent tumor stem cells drive chemoresistance in breast cancer through NF-kappaB survival pathway.
Kumar S, Nandi A, Singh S, Regulapati R, Li N, Tobias JW, Siebel CW, Blanco MA, Klein-Szanto AJ, Lengner C, Welm AL, Kang Y, Chakrabarti R. Kumar S, et al. Nat Commun. 2021 Jan 18;12(1):432. doi: 10.1038/s41467-020-20664-5. Nat Commun. 2021. PMID: 33462238 Free PMC article.
Using conditional knockout and reporter mouse models, we demonstrate that tumor cells expressing the Notch ligand Dll1 is important for tumor growth and metastasis and bear similarities to tumor-initiating cancer cells (TICs) in breast cancer. RNA-seq and ATA …
Using conditional knockout and reporter mouse models, we demonstrate that tumor cells expressing the Notch ligand Dll1 is important f …
Precision medicine for human cancers with Notch signaling dysregulation (Review).
Katoh M, Katoh M. Katoh M, et al. Int J Mol Med. 2020 Feb;45(2):279-297. doi: 10.3892/ijmm.2019.4418. Epub 2019 Dec 4. Int J Mol Med. 2020. PMID: 31894255 Free PMC article. Review.
Notch signaling is aberrantly activated in breast cancer, non-small-cell lung cancer and hematological malignancies, such as T-cell acute lymphoblastic leukemia and diffuse large B-cell lymphoma. ...ADCs and CAR-Ts could alter the therapeutic framework for refractor …
Notch signaling is aberrantly activated in breast cancer, non-small-cell lung cancer and hematological malignancies, such as T …
Dll1-Mediated Notch Signaling Drives Tumor Cell Cross-talk with Cancer-Associated Fibroblasts to Promote Radioresistance in Breast Cancer.
Nandi A, Debnath R, Nayak A, To TKJ, Thacker G, Reilly M, Gumber S, Karagounis I, Li N, Lengner CJ, Haldar M, Welm AL, Blanco AM, Thomas C, Chakrabarti R. Nandi A, et al. Cancer Res. 2022 Oct 17;82(20):3718-3733. doi: 10.1158/0008-5472.CAN-21-1225. Cancer Res. 2022. PMID: 36007109 Free PMC article.
Dll1+ breast cancer cells activate Notch signaling in cancer-associated fibroblasts that increases Wnt ligand secretion and leads to beta-catenin-driven radioresistance and metastasis, opening new therapeutic avenues for breast cancer....
Dll1+ breast cancer cells activate Notch signaling in cancer-associated fibroblasts that increases Wnt ligand secretion …
Anti-Jagged-1 immunotherapy in cancer.
Pancewicz J, Niklinska W, Eljaszewicz A. Pancewicz J, et al. Adv Med Sci. 2022 Sep;67(2):196-202. doi: 10.1016/j.advms.2022.04.001. Epub 2022 Apr 11. Adv Med Sci. 2022. PMID: 35421813 Review.
The human Notch family includes four receptors, Notch 1-4, and five ligands, delta-like ligand 1 (DLL1), delta-like ligand 3 (DLL3), delta-like ligand 4 (DLL4), Jagged-1 (JAG1), and Jagged-2 (JAG2). ...Human JAG1 is closely related to tumor biology among the Notch ligands, …
The human Notch family includes four receptors, Notch 1-4, and five ligands, delta-like ligand 1 (DLL1), delta-like ligand 3 (DLL3), …
Tamoxifen Downregulates the Expression of Notch1 and DLL1 Genes in MKN-45 Gastric Cancer Cells.
Khanipouyani F, Akrami H. Khanipouyani F, et al. J Gastrointest Cancer. 2021 Sep;52(3):922-927. doi: 10.1007/s12029-020-00511-y. J Gastrointest Cancer. 2021. PMID: 32901446
PURPOSE: Gastric cancer is one of the most prevalent cancers worldwide and the second most common cause for cancer associated mortality. Anti-tumor effects of tamoxifen in breast cancer are well-established. However, no study has so far investigated th …
PURPOSE: Gastric cancer is one of the most prevalent cancers worldwide and the second most common cause for cancer asso …
The Notch ligand DLL1 exerts carcinogenic features in human breast cancer cells.
Sales-Dias J, Silva G, Lamy M, Ferreira A, Barbas A. Sales-Dias J, et al. PLoS One. 2019 May 20;14(5):e0217002. doi: 10.1371/journal.pone.0217002. eCollection 2019. PLoS One. 2019. PMID: 31107884 Free PMC article.
These findings provide further evidence that DLL1 exerts carcinogenic effects in BC cells. The dissimilar effects of DLL1 downregulation observed amongst MCF-7, BT474, and MDA-MB-231 cells is likely due to their distinctive genetic and biologic characteristics, sugg …
These findings provide further evidence that DLL1 exerts carcinogenic effects in BC cells. The dissimilar effects of DLL1 down …
200 results