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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1968 1
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1982 7
1983 24
1984 22
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1988 33
1989 32
1990 43
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1992 42
1993 25
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1995 49
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1998 60
1999 80
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2004 138
2005 168
2006 192
2007 235
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2009 267
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2011 389
2012 441
2013 525
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2015 570
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2018 495
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9,337 results

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Page 1
Active DNA Demethylation in Plants.
Parrilla-Doblas JT, Roldán-Arjona T, Ariza RR, Córdoba-Cañero D. Parrilla-Doblas JT, et al. Int J Mol Sci. 2019 Sep 21;20(19):4683. doi: 10.3390/ijms20194683. Int J Mol Sci. 2019. PMID: 31546611 Free PMC article. Review.
Plants are unique in possessing a mechanism for active DNA demethylation involving DNA glycosylases that excise 5-meC and initiate its replacement with unmodified C through a base excision repair (BER) pathway. Plant BER-mediated DNA demethylation …
Plants are unique in possessing a mechanism for active DNA demethylation involving DNA glycosylases that excise 5-meC a …
Active DNA demethylation promotes cell fate specification and the DNA damage response.
Wang D, Wu W, Callen E, Pavani R, Zolnerowich N, Kodali S, Zong D, Wong N, Noriega S, Nathan WJ, Matos-Rodrigues G, Chari R, Kruhlak MJ, Livak F, Ward M, Caldecott K, Di Stefano B, Nussenzweig A. Wang D, et al. Science. 2022 Dec 2;378(6623):983-989. doi: 10.1126/science.add9838. Epub 2022 Dec 1. Science. 2022. PMID: 36454826 Free PMC article.
Neurons harbor high levels of single-strand DNA breaks (SSBs) that are targeted to neuronal enhancers, but the source of this endogenous damage remains unclear. ...Disrupting this gap-filling process using anti-neoplastic cytosine analogs triggers a DNA damage respo …
Neurons harbor high levels of single-strand DNA breaks (SSBs) that are targeted to neuronal enhancers, but the source of this endogen …
RNA m(6)A regulates transcription via DNA demethylation and chromatin accessibility.
Deng S, Zhang J, Su J, Zuo Z, Zeng L, Liu K, Zheng Y, Huang X, Bai R, Zhuang L, Ye Y, Li M, Pan L, Deng J, Wu G, Li R, Zhang S, Wu C, Lin D, Chen J, Zheng J. Deng S, et al. Nat Genet. 2022 Sep;54(9):1427-1437. doi: 10.1038/s41588-022-01173-1. Epub 2022 Sep 7. Nat Genet. 2022. PMID: 36071173
Here, we show that METTL3-mediated RNA N(6)-methyladenosine (m(6)A) formation leads to DNA demethylation in nearby genomic loci in normal and cancer cells, which is mediated by the interaction between m(6)A reader FXR1 and DNA 5-methylcytosine dioxygenase TET …
Here, we show that METTL3-mediated RNA N(6)-methyladenosine (m(6)A) formation leads to DNA demethylation in nearby genomic loc …
Active DNA demethylation in plants: 20 years of discovery and beyond.
Zhang H, Gong Z, Zhu JK. Zhang H, et al. J Integr Plant Biol. 2022 Dec;64(12):2217-2239. doi: 10.1111/jipb.13423. J Integr Plant Biol. 2022. PMID: 36478523 Review.
The discovery of the first eukaryotic DNA demethylase, Arabidopsis thaliana REPRESSOR OF SILENCING 1 (ROS1), led to elucidation of the 5-methylcytosine base excision repair mechanism of active DNA demethylation. In the 20 years since ROS1 was discovered, our …
The discovery of the first eukaryotic DNA demethylase, Arabidopsis thaliana REPRESSOR OF SILENCING 1 (ROS1), led to elucidation of th …
TET Enzymes in the Immune System: From DNA Demethylation to Immunotherapy, Inflammation, and Cancer.
López-Moyado IF, Ko M, Hogan PG, Rao A. López-Moyado IF, et al. Annu Rev Immunol. 2024 Jun;42(1):455-488. doi: 10.1146/annurev-immunol-080223-044610. Epub 2024 Jun 14. Annu Rev Immunol. 2024. PMID: 38360546 Free article. Review.
All three epigenetic modifications are intermediates in DNA demethylation. TET proteins are recruited by transcription factors and by RNA polymerase II to modify 5mC at enhancers and gene bodies, thereby regulating gene expression during development, cell lineage sp …
All three epigenetic modifications are intermediates in DNA demethylation. TET proteins are recruited by transcription factors …
Delineation of a Human Mendelian Disorder of the DNA Demethylation Machinery: TET3 Deficiency.
Beck DB, Petracovici A, He C, Moore HW, Louie RJ, Ansar M, Douzgou S, Sithambaram S, Cottrell T, Santos-Cortez RLP, Prijoles EJ, Bend R, Keren B, Mignot C, Nougues MC, Õunap K, Reimand T, Pajusalu S, Zahid M, Saqib MAN, Buratti J, Seaby EG, McWalter K, Telegrafi A, Baldridge D, Shinawi M, Leal SM, Schaefer GB, Stevenson RE, Banka S, Bonasio R, Fahrner JA. Beck DB, et al. Am J Hum Genet. 2020 Feb 6;106(2):234-245. doi: 10.1016/j.ajhg.2019.12.007. Epub 2020 Jan 9. Am J Hum Genet. 2020. PMID: 31928709 Free PMC article.
These enzymes catalyze reactions that regulate epigenetic inheritance via histone post-translational modifications and DNA methylation. Cytosine methylation (5-methylcytosine [5mC]) of DNA is the quintessential epigenetic mark, yet no human Mendelian disorder of …
These enzymes catalyze reactions that regulate epigenetic inheritance via histone post-translational modifications and DNA methylatio …
DNA demethylation pathways: Additional players and regulators.
Bochtler M, Kolano A, Xu GL. Bochtler M, et al. Bioessays. 2017 Jan;39(1):1-13. doi: 10.1002/bies.201600178. Epub 2016 Nov 16. Bioessays. 2017. PMID: 27859411 Review.
DNA demethylation can occur passively by "dilution" of methylation marks by DNA replication, or actively and independently of DNA replication. ...They identify base excision repair (BER) glycosylases that may cooperate with or replace thymine DNA …
DNA demethylation can occur passively by "dilution" of methylation marks by DNA replication, or actively and independen …
Active DNA demethylation-The epigenetic gatekeeper of development, immunity, and cancer.
Prasad R, Yen TJ, Bellacosa A. Prasad R, et al. Adv Genet (Hoboken). 2020 Nov 27;2(1):e10033. doi: 10.1002/ggn2.10033. eCollection 2021 Mar. Adv Genet (Hoboken). 2020. PMID: 36618446 Free PMC article. Review.
However, in the past two decades, physiologically controlled DNA demethylation and deamination processes have been identified, thereby revealing the function of cytosine methylation as a highly regulated and complex state-not simply a static, inherited signature or …
However, in the past two decades, physiologically controlled DNA demethylation and deamination processes have been identified, …
Single-cell multi-omics sequencing of human spermatogenesis reveals a DNA demethylation event associated with male meiotic recombination.
Huang Y, Li L, An G, Yang X, Cui M, Song X, Lin J, Zhang X, Yao Z, Wan C, Zhou C, Zhao J, Song K, Ren S, Xia X, Fu X, Lan Y, Hu X, Wang W, Wang M, Zheng Y, Miao K, Bai X, Hutchins AP, Chang G, Gao S, Zhao XY. Huang Y, et al. Nat Cell Biol. 2023 Oct;25(10):1520-1534. doi: 10.1038/s41556-023-01232-7. Epub 2023 Sep 18. Nat Cell Biol. 2023. PMID: 37723297
In particular, we identified a set of transcription factors and cis elements with potential functions. A round of DNA demethylation was uncovered upon meiosis initiation in human spermatogenesis, which was associated with male meiotic recombination and conserved bet …
In particular, we identified a set of transcription factors and cis elements with potential functions. A round of DNA demethylatio …
Induction of DNA Demethylation: Strategies and Consequences.
Carollo PS, Barra V. Carollo PS, et al. Epigenomes. 2025 Apr 12;9(2):11. doi: 10.3390/epigenomes9020011. Epigenomes. 2025. PMID: 40265378 Free PMC article. Review.
Different strategies have been developed to study the effects of DNA methylation in cells, involving either DNMTs inhibition (passive DNA demethylation) or the use of Ten-eleven translocation protein (TET) family enzymes, which directly demethylate DNA …
Different strategies have been developed to study the effects of DNA methylation in cells, involving either DNMTs inhibition (passive …
9,337 results