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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1961 2
1962 5
1963 1
1964 10
1965 15
1966 23
1967 29
1968 68
1969 60
1970 81
1971 175
1972 305
1973 309
1974 365
1975 515
1976 426
1977 449
1978 503
1979 548
1980 619
1981 646
1982 774
1983 710
1984 858
1985 956
1986 866
1987 883
1988 929
1989 1031
1990 963
1991 1073
1992 1057
1993 1195
1994 1422
1995 1442
1996 1747
1997 1751
1998 1876
1999 2105
2000 2392
2001 2593
2002 2706
2003 2936
2004 3185
2005 3421
2006 3660
2007 3763
2008 3819
2009 4108
2010 4525
2011 4715
2012 5021
2013 5130
2014 5398
2015 5403
2016 5477
2017 5542
2018 5609
2019 5791
2020 6548
2021 7043
2022 6558
2023 6148
2024 6336
2025 7214
2026 4543

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143,979 results

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Page 1
DNA repair defects in cancer and therapeutic opportunities.
Hopkins JL, Lan L, Zou L. Hopkins JL, et al. Genes Dev. 2022 Mar 1;36(5-6):278-293. doi: 10.1101/gad.349431.122. Genes Dev. 2022. PMID: 35318271 Free PMC article. Review.
DNA repair and DNA damage signaling pathways are critical for the maintenance of genomic stability. ...Furthermore, we discuss the impacts of DNA repair defects on both targeted therapy and immunotherapy, and highlight emerging principles for ta …
DNA repair and DNA damage signaling pathways are critical for the maintenance of genomic stability. ...Furthermore, we …
Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints.
Sancar A, Lindsey-Boltz LA, Unsal-Kaçmaz K, Linn S. Sancar A, et al. Annu Rev Biochem. 2004;73:39-85. doi: 10.1146/annurev.biochem.73.011303.073723. Annu Rev Biochem. 2004. PMID: 15189136 Review.
DNA repair mechanisms include direct repair, base excision repair, nucleotide excision repair, double-strand break repair, and cross-link repair. ...The signal transducers activate p53 and inactivate cyclin-dependent kinases to inh …
DNA repair mechanisms include direct repair, base excision repair, nucleotide excision repair, double-str …
Prime Editing: Mechanistic Insights and DNA Repair Modulation.
Mentani A, Maresca M, Shiriaeva A. Mentani A, et al. Cells. 2025 Feb 13;14(4):277. doi: 10.3390/cells14040277. Cells. 2025. PMID: 39996750 Free PMC article. Review.
When prime editing occurs, the DNA undergoes one of several DNA repair pathways, and these processes can be modulated with the use of inhibitors. Firstly, this review provides an overview of several DNA repair mechanisms and their modulation by …
When prime editing occurs, the DNA undergoes one of several DNA repair pathways, and these processes can be modulated w …
Transcription-Coupled Nucleotide Excision Repair and the Transcriptional Response to UV-Induced DNA Damage.
Nieto Moreno N, Olthof AM, Svejstrup JQ. Nieto Moreno N, et al. Annu Rev Biochem. 2023 Jun 20;92:81-113. doi: 10.1146/annurev-biochem-052621-091205. Epub 2023 Apr 11. Annu Rev Biochem. 2023. PMID: 37040775 Free article. Review.
Ultraviolet (UV) irradiation and other genotoxic stresses induce bulky DNA lesions, which threaten genome stability and cell viability. Cells have evolved two main repair pathways to remove such lesions: global genome nucleotide excision repair (GG-NER) and t …
Ultraviolet (UV) irradiation and other genotoxic stresses induce bulky DNA lesions, which threaten genome stability and cell viabilit …
DNA repair.
Barnes DE, Lindahl T, Sedgwick B. Barnes DE, et al. Curr Opin Cell Biol. 1993 Jun;5(3):424-33. doi: 10.1016/0955-0674(93)90007-d. Curr Opin Cell Biol. 1993. PMID: 8352959 Review.
Multiple DNA repair processes are required to maintain the integrity of the cellular genome. Recent advances, including elucidation of three-dimensional structures of DNA repair enzymes, and the cloning and characterization of DNA repair …
Multiple DNA repair processes are required to maintain the integrity of the cellular genome. Recent advances, including elucid …
DNA damage and repair following traumatic brain injury.
Davis CK, Vemuganti R. Davis CK, et al. Neurobiol Dis. 2021 Jan;147:105143. doi: 10.1016/j.nbd.2020.105143. Epub 2020 Oct 28. Neurobiol Dis. 2021. PMID: 33127471 Free article. Review.
Although several DNA repair pathways are induced following TBI, the simultaneous downregulation of some of the genes and proteins of these pathways leads to an aberrant overall DNA repair process. ...The persisting DNA damage and/or lack of D …
Although several DNA repair pathways are induced following TBI, the simultaneous downregulation of some of the genes and prote …
Chromothripsis, DNA repair and checkpoints defects.
Simovic M, Ernst A. Simovic M, et al. Semin Cell Dev Biol. 2022 Mar;123:110-114. doi: 10.1016/j.semcdb.2021.02.001. Epub 2021 Feb 13. Semin Cell Dev Biol. 2022. PMID: 33589336 Free article. Review.
Chromothripsis is a unique form of genome instability characterized by tens to hundreds of DNA double-strand breaks on one or very few chromosomes, followed by error-prone repair. ...Chromothripsis plays a major role in cancer as well as in other conditions, such as …
Chromothripsis is a unique form of genome instability characterized by tens to hundreds of DNA double-strand breaks on one or very fe …
Targeting DNA Repair in Ovarian Cancer Treatment Resistance.
Wong-Brown MW, van der Westhuizen A, Bowden NA. Wong-Brown MW, et al. Clin Oncol (R Coll Radiol). 2020 Aug;32(8):518-526. doi: 10.1016/j.clon.2020.03.005. Epub 2020 Apr 3. Clin Oncol (R Coll Radiol). 2020. PMID: 32253106 Review.
In addition, if the repair pathways are epigenetically inactivated by DNA methylation, cell death may not be triggered, resulting in accumulation of mutations and DNA damage. There are novel and existing therapies that can drive DNA repair pathw …
In addition, if the repair pathways are epigenetically inactivated by DNA methylation, cell death may not be triggered, result …
DNA Repair Mechanisms and Therapeutic Targets in Glioma.
Elmore KB, Schaff LR. Elmore KB, et al. Curr Oncol Rep. 2021 Jun 14;23(8):87. doi: 10.1007/s11912-021-01077-z. Curr Oncol Rep. 2021. PMID: 34125307 Review.
PURPOSE OF REVIEW: This review discusses current and investigative strategies for targeting DNA repair in the management of glioma. RECENT FINDINGS: Recent strategies in glioma treatment rely on the production of overwhelming DNA damage and inhibition of r …
PURPOSE OF REVIEW: This review discusses current and investigative strategies for targeting DNA repair in the management of gl …
DNA repair nucleases.
Marti TM, Fleck O. Marti TM, et al. Cell Mol Life Sci. 2004 Feb;61(3):336-54. doi: 10.1007/s00018-003-3223-4. Cell Mol Life Sci. 2004. PMID: 14770297 Free PMC article. Review.
Stability of DNA largely depends on accuracy of repair mechanisms, which remove structural anomalies induced by exogenous and endogenous agents or introduced by DNA metabolism, such as replication. ...DNA nucleases play a crucial role in mismatch re …
Stability of DNA largely depends on accuracy of repair mechanisms, which remove structural anomalies induced by exogenous and …
143,979 results
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