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26 results

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Page 1
Siling decoction ameliorates adenine-induced renal fibrosis in rats by the AKT/IKKβ/NFκB signaling pathway.
Zeng L, Lin Y, Chen H, Li X, Xie D, Li Y, Hu K. Zeng L, et al. Phytomedicine. 2024 Dec;135:156228. doi: 10.1016/j.phymed.2024.156228. Epub 2024 Nov 8. Phytomedicine. 2024. PMID: 39550923
RESULTS: Network pharmacology analysis identified 100 common targets associated with the active components of SLD, including core genes such as AKT1 and CCND1. GO enrichment analysis revealed that the top three biological processes impacted include response to xenobiotic s …
RESULTS: Network pharmacology analysis identified 100 common targets associated with the active components of SLD, including core gen …
The transcriptional coactivator PC4/Sub1 has multiple functions in RNA polymerase II transcription.
Calvo O, Manley JL. Calvo O, et al. EMBO J. 2005 Mar 9;24(5):1009-20. doi: 10.1038/sj.emboj.7600575. Epub 2005 Feb 3. EMBO J. 2005. PMID: 15692559 Free PMC article.
We described previously an unexpected association between a transcription factor, PC4 (or Sub1 in yeast), and an mRNA polyadenylation factor, CstF-64 (Rna15 in yeast), and provided evidence that this was important for efficient transcription elongation. ...We show t …
We described previously an unexpected association between a transcription factor, PC4 (or Sub1 in yeast), and an mRNA polyadenylation …
A testis-specific transcription factor IIA (TFIIAtau) stimulates TATA-binding protein-DNA binding and transcription activation.
Ozer J, Moore PA, Lieberman PM. Ozer J, et al. J Biol Chem. 2000 Jan 7;275(1):122-8. doi: 10.1074/jbc.275.1.122. J Biol Chem. 2000. PMID: 10617594 Free article.
The general transcription factor IIA (TFIIA) stimulates RNA polymerase II-specific transcription by stabilizing the association of the TATA-binding protein (TBP) with promoter DNA, inhibiting repressors of TBP, and facilitating activat …
The general transcription factor IIA (TFIIA) stimulates RNA polymerase II-specific transcription b …
Computational Analysis of Single Nucleotide Polymorphisms in Human HIC1 Gene.
Annanya A, Priyadharshini B, Suresh V, Dilipan E. Annanya A, et al. Cureus. 2024 Mar 21;16(3):e56664. doi: 10.7759/cureus.56664. eCollection 2024 Mar. Cureus. 2024. PMID: 38646326 Free PMC article.
The molecular function of HIC1 gene includes DNA-binding transcription factor activity, sequence-specific DNA binding, DNA binding, histone deacetylase binding, protein binding, metal ion binding, nucleic acid binding …
The molecular function of HIC1 gene includes DNA-binding transcription factor activity, sequence-specific DNA …
Retinoid-dependent transcription: the RAR/RXR-TBP-EIA/EIA-LA connection.
Meyer M, Sonntag-Buck V, Keaveney M, Stunnenberg HG. Meyer M, et al. Biochem Soc Symp. 1996;62:97-109. Biochem Soc Symp. 1996. PMID: 8971343 Review.
Co-immunoprecipitation experiments show that E1A13S is an integral component of the RNA polymerase II-specific TBP-containing complex in adenovirus transformed embryonal kidney 293 cells. Taken together the results suggest that E1A13S mediates trans …
Co-immunoprecipitation experiments show that E1A13S is an integral component of the RNA polymerase II-specific T …
Transcription activation by a variety of AraC/XylS family activators does not depend on the class II-specific activation determinant in the N-terminal domain of the RNA polymerase alpha subunit.
Egan SM, Pease AJ, Lang J, Li X, Rao V, Gillette WK, Ruiz R, Ramos JL, Wolf RE Jr. Egan SM, et al. J Bacteriol. 2000 Dec;182(24):7075-7. doi: 10.1128/JB.182.24.7075-7077.2000. J Bacteriol. 2000. PMID: 11092872 Free PMC article.
The N-terminal domain of the RNA polymerase alpha subunit (alpha-NTD) was tested for a role in transcription activation by a variety of AraC/XylS family members. Based on substitutions at residues 162 to 165 and an extensive genetic screen we co …
The N-terminal domain of the RNA polymerase alpha subunit (alpha-NTD) was tested for a role in transcription activat …
Analysis of the yeast transcription factor TFIIA: distinct functional regions and a polymerase II-specific role in basal and activated transcription.
Kang JJ, Auble DT, Ranish JA, Hahn S. Kang JJ, et al. Mol Cell Biol. 1995 Mar;15(3):1234-43. doi: 10.1128/MCB.15.3.1234. Mol Cell Biol. 1995. PMID: 7862117 Free PMC article.
Much of the conserved regions of both subunits is required for subunit association, suggesting that these conserved regions fold into compact domains which extensively interact. In vitro transcription performed with extracts from yeast strains with mutations in either the …
Much of the conserved regions of both subunits is required for subunit association, suggesting that these conserved regions fold into compac …
Isolation and characterization of TAF25, an essential yeast gene that encodes an RNA polymerase II-specific TATA-binding protein-associated factor.
Klebanow ER, Poon D, Zhou S, Weil PA. Klebanow ER, et al. J Biol Chem. 1996 Jun 7;271(23):13706-15. doi: 10.1074/jbc.271.23.13706. J Biol Chem. 1996. PMID: 8662725 Free article.
The results from immunological studies confirm that yTAF25 is a subunit of a large multiprotein TATA-binding protein-yeast TATA-binding protein-associated factor complex that contains a subset of the total number of the yTAFs present in yeast cell extracts. Both genetic an …
The results from immunological studies confirm that yTAF25 is a subunit of a large multiprotein TATA-binding protein-yeast TATA-binding prot …
Investigation of the mechanisms and experimental verification of Cuscuta-Salvia in the treatment of polycystic ovary syndrome (PCOS) via network pharmacology.
Zhang YY, Ma JX, Zhu YT, Wang YX, Chen WQ, Sun X, Zhang W, Wang CY, Ding CF. Zhang YY, et al. J Ovarian Res. 2022 Apr 4;15(1):40. doi: 10.1186/s13048-022-00964-8. J Ovarian Res. 2022. PMID: 35379295 Free PMC article.
However, its chemical and pharmacological properties remain unclear. We identified the active components and related targets of Cuscuta-Salvia using UHPLC-ESI-Q-TOF-MS and TCMSP database. ...GO results showed that cellular response to drugs, response to oxygen levels, resp …
However, its chemical and pharmacological properties remain unclear. We identified the active components and related targets of Cuscu …
Mechanism of Epimedium intervention in heart failure based on network pharmacology and molecular docking technology.
Boyang C, Yuexing L, Yiping Y, Haiyang Y, Lingjie Z, Liancheng G, Xufei Z, Jie Z, Yunzhi C. Boyang C, et al. Medicine (Baltimore). 2022 Nov 25;101(47):e32059. doi: 10.1097/MD.0000000000032059. Medicine (Baltimore). 2022. PMID: 36451478 Free PMC article.
Molecular docking validation showed better binding activity of the major targets of HF to the core components of Epimedium. The biological pathways that Epimedium regulates HF mainly act on lipid and atherosclerotic pathways, PI3K-Akt signaling pathway, and chemoattractant …
Molecular docking validation showed better binding activity of the major targets of HF to the core components of Epimedium. The biolo …
26 results