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Year Number of Results
1993 1
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5,438 results

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Page 1
DNMT3A in Leukemia.
Brunetti L, Gundry MC, Goodell MA. Brunetti L, et al. Cold Spring Harb Perspect Med. 2017 Feb 1;7(2):a030320. doi: 10.1101/cshperspect.a030320. Cold Spring Harb Perspect Med. 2017. PMID: 28003281 Free PMC article. Review.
DNMT3A mutations are early events during cancer development and seem to confer poor prognosis to acute myeloid leukemia (AML) patients making this gene an attractive target for new therapies. Here, we discuss the biology of DNMT3A and its role in controlling hematop …
DNMT3A mutations are early events during cancer development and seem to confer poor prognosis to acute myeloid leukemia (AML) patient …
DNMT3A-R882: a mutation with many paradoxes.
Jafari PA, Bagheri R, Lavasani S, Goudarzi S. Jafari PA, et al. Ann Hematol. 2024 Dec;103(12):4981-4988. doi: 10.1007/s00277-024-05874-x. Epub 2024 Jul 6. Ann Hematol. 2024. PMID: 38969930 Review.
DNA (cytosine-5)-methyltransferase 3 A (DNMT3A) is considered a prognostic and therapeutic epigenetic target in AML patients with a hotspot mutation of R882. ...
DNA (cytosine-5)-methyltransferase 3 A (DNMT3A) is considered a prognostic and therapeutic epigenetic target in AML patients with a h …
Alterations to DNMT3A in Hematologic Malignancies.
Venugopal K, Feng Y, Shabashvili D, Guryanova OA. Venugopal K, et al. Cancer Res. 2021 Jan 15;81(2):254-263. doi: 10.1158/0008-5472.CAN-20-3033. Epub 2020 Oct 21. Cancer Res. 2021. PMID: 33087320 Free PMC article. Review.
We then review the role played by mutant DNMT3A in clonal hematopoiesis, accompanied by its effect on immune cell function and inflammatory responses. Finally, we discuss how this knowledge informs therapeutic approaches for hematologic malignancies with mutant DNMT3A …
We then review the role played by mutant DNMT3A in clonal hematopoiesis, accompanied by its effect on immune cell function and inflam …
DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development.
Okano M, Bell DW, Haber DA, Li E. Okano M, et al. Cell. 1999 Oct 29;99(3):247-57. doi: 10.1016/s0092-8674(00)81656-6. Cell. 1999. PMID: 10555141 Free article.
Dnmt3a and Dnmt3b also exhibit nonoverlapping functions in development, with Dnmt3b specifically required for methylation of centromeric minor satellite repeats. Mutations of human DNMT3B are found in ICF syndrome, a developmental defect characterized by hypomethylation of …
Dnmt3a and Dnmt3b also exhibit nonoverlapping functions in development, with Dnmt3b specifically required for methylation of centrome …
Dnmt3a-mediated hypermethylation of FoxO3 promotes redox imbalance during osteoclastogenesis.
Zhang W, Li W, Du J, Yang C, Yu L, Yang P, Zhang H, Wu Z, Ge G, Yang H, Geng D. Zhang W, et al. Proc Natl Acad Sci U S A. 2025 Mar 25;122(12):e2418023122. doi: 10.1073/pnas.2418023122. Epub 2025 Mar 19. Proc Natl Acad Sci U S A. 2025. PMID: 40106360 Free PMC article.
Mechanistically, we identified FoxO3 promoter methylation as a crucial factor contributing to decreased FoxO3, thereby influencing osteoclastogenesis and OC function. Intriguingly, we observed that Dnmt3a, highly expressed during osteoclastogenesis, played a pivotal role i …
Mechanistically, we identified FoxO3 promoter methylation as a crucial factor contributing to decreased FoxO3, thereby influencing osteoclas …
DNMT3A mutation promotes leukemia development through NAM-NAD metabolic reprogramming.
Yang X, Wang X, Yang Y, Li Z, Chen Y, Shang S, Wang Y. Yang X, et al. J Transl Med. 2023 Jul 18;21(1):481. doi: 10.1186/s12967-023-04323-z. J Transl Med. 2023. PMID: 37464424 Free PMC article.
BACKGROUND: DNA methyltransferase 3A (DNMT3A) is frequently mutated in acute myeloid leukemia (AML) with Arg882His (R882H) as the hotspot mutation. ...In this study, we investigated the function of DNMT3A R882H in the malignant progression of AML by regulating metab …
BACKGROUND: DNA methyltransferase 3A (DNMT3A) is frequently mutated in acute myeloid leukemia (AML) with Arg882His (R882H) as the hot …
DNMT3A gates IFN-induced MPN HSC exhaustion.
Constantinescu SN, Vainchenker W. Constantinescu SN, et al. Blood. 2024 Jun 13;143(24):2445-2446. doi: 10.1182/blood.2024024448. Blood. 2024. PMID: 38869916 Free article. No abstract available.
DNMT3A in haematological malignancies.
Yang L, Rau R, Goodell MA. Yang L, et al. Nat Rev Cancer. 2015 Mar;15(3):152-65. doi: 10.1038/nrc3895. Epub 2015 Feb 19. Nat Rev Cancer. 2015. PMID: 25693834 Free PMC article. Review.
Recently, however, mutations in the gene encoding DNA methyltransferase 3A (DNMT3A) were reported in patients with acute myeloid leukaemia (AML), and subsequently in patients with various other haematological malignancies, pointing to DNMT3A as a critically importan …
Recently, however, mutations in the gene encoding DNA methyltransferase 3A (DNMT3A) were reported in patients with acute myeloid leuk …
AML-Associated Mutations in DNA Methyltransferase DNMT3A.
Khrabrova DA, Yakubovskaya MG, Gromova ES. Khrabrova DA, et al. Biochemistry (Mosc). 2021 Mar;86(3):307-318. doi: 10.1134/S000629792103007X. Biochemistry (Mosc). 2021. PMID: 33838631 Review.
This mutation is the only one that has been extensively studied using both model DNA substrates and cancer cell lines. Biochemical characterization of other DNMT3A mutants is necessary to assess their potential effects on the DNMT3A functioning. In this review, we d …
This mutation is the only one that has been extensively studied using both model DNA substrates and cancer cell lines. Biochemical character …
DNMT3A -448A>G polymorphism and cancer risk: a meta-analysis.
Liu CH, Tao T, Jiang L, Xu B, Zhang L, Lu K, Zhang XW, Chen SQ, Liu DC, Chen M. Liu CH, et al. Genet Mol Res. 2015 Apr 17;14(2):3640-9. doi: 10.4238/2015.April.17.14. Genet Mol Res. 2015. PMID: 25966133 Free article.
DNA (cytosine-5)-methyltransferase 3A (DNMT3A) is the main de novo methyltransferase implicated in this process. In DNMT3A, the -448A>G polymorphism is associated with cancer; however, the results of various studies have been conflicting. ...Odds ratios with 95% …
DNA (cytosine-5)-methyltransferase 3A (DNMT3A) is the main de novo methyltransferase implicated in this process. In DNMT3A, th …
5,438 results