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Spatial and temporal immunoreactivity in the rat brain using an affinity purified polyclonal antibody to DNSP-11.
Sonne JWH, Groshong JS, Seavey C, Gash DM. Sonne JWH, et al. J Chem Neuroanat. 2019 Oct;100:101664. doi: 10.1016/j.jchemneu.2019.101664. Epub 2019 Aug 5. J Chem Neuroanat. 2019. PMID: 31394198 Free PMC article.
DNSP-11 antibody signal was investigated in perfusion fixated Fischer 344 rat brains by immunohistochemistry with a custom, affinity purified polyclonal antibody. The DNSP-11-antibody signal was differentially localized from the mature GDNF protein bot …
DNSP-11 antibody signal was investigated in perfusion fixated Fischer 344 rat brains by immunohistochemistry with a custom, af …
Methodology and effects of repeated intranasal delivery of DNSP-11 in awake Rhesus macaques.
Stenslik MJ, Evans A, Pomerleau F, Weeks R, Huettl P, Foreman E, Turchan-Cholewo J, Andersen A, Cass WA, Zhang Z, Grondin RC, Gash DM, Gerhardt GA, Bradley LH. Stenslik MJ, et al. J Neurosci Methods. 2018 Jun 1;303:30-40. doi: 10.1016/j.jneumeth.2018.03.006. Epub 2018 Mar 31. J Neurosci Methods. 2018. PMID: 29614295 Free PMC article.
We evaluated the effects of the neuroactive peptide, DNSP-11 following repeated intranasal delivery and dose-escalation over the course of 10-weeks in Rhesus macaques. ...Furthermore, a (125)I-labeled DNSP-11 study illustrates diffuse rostral to caudal …
We evaluated the effects of the neuroactive peptide, DNSP-11 following repeated intranasal delivery and dose-escalation over t …
Dynamic changes in dopamine neuron function after DNSP-11 treatment: effects in vivo and increased ERK 1/2 phosphorylation in vitro.
Fuqua JL, Littrell OM, Lundblad M, Turchan-Cholewo J, Abdelmoti LG, Galperin E, Bradley LH, Cass WA, Gash DM, Gerhardt GA. Fuqua JL, et al. Peptides. 2014 Apr;54:1-8. doi: 10.1016/j.peptides.2013.12.007. Epub 2014 Jan 7. Peptides. 2014. PMID: 24406899 Free PMC article.
A post-translational processing model of the human GDNF proprotein theorizes the formation of smaller, amidated peptide(s) from the proregion that exhibit neurobiological function, including an 11-amino-acid peptide named dopamine neuron stimulating peptide-11 (DNSP …
A post-translational processing model of the human GDNF proprotein theorizes the formation of smaller, amidated peptide(s) from the proregio …
Dopamine neuron stimulating actions of a GDNF propeptide.
Bradley LH, Fuqua J, Richardson A, Turchan-Cholewo J, Ai Y, Kelps KA, Glass JD, He X, Zhang Z, Grondin R, Littrell OM, Huettl P, Pomerleau F, Gash DM, Gerhardt GA. Bradley LH, et al. PLoS One. 2010 Mar 18;5(3):e9752. doi: 10.1371/journal.pone.0009752. PLoS One. 2010. PMID: 20305789 Free PMC article.
METHODS AND FINDINGS: Here we present the neurobiological actions of dopamine neuron stimulating peptide-11 (DNSP-11), an 11-mer peptide from the proGDNF domain. In vitro, DNSP-11 supports the survival of fetal mesencephalic neurons, increasing …
METHODS AND FINDINGS: Here we present the neurobiological actions of dopamine neuron stimulating peptide-11 (DNSP-11), …
Methodology and effects of repeated intranasal delivery of DNSP-11 in a rat model of Parkinson's disease.
Stenslik MJ, Potts LF, Sonne JW, Cass WA, Turchan-Cholewo J, Pomerleau F, Huettl P, Ai Y, Gash DM, Gerhardt GA, Bradley LH. Stenslik MJ, et al. J Neurosci Methods. 2015 Aug 15;251:120-9. doi: 10.1016/j.jneumeth.2015.05.006. Epub 2015 May 18. J Neurosci Methods. 2015. PMID: 25999268 Free PMC article.
NEW METHOD: We developed a methodology for evaluating the effects of a synthetic neuroactive peptide, DNSP-11, on the nigrostriatal system using repeated intranasal delivery in both normal and a unilateral 6-hydroxydopamine (6-OHDA) lesion rat model of PD. ...COMPAR …
NEW METHOD: We developed a methodology for evaluating the effects of a synthetic neuroactive peptide, DNSP-11, on the nigrostr …
Evaluation of the physical and in vitro protective activity of three synthetic peptides derived from the pro- and mature GDNF sequence.
Kelps KA, Turchan-Cholewo J, Hascup ER, Taylor TL, Gash DM, Gerhardt GA, Bradley LH. Kelps KA, et al. Neuropeptides. 2011 Jun;45(3):213-8. doi: 10.1016/j.npep.2011.03.003. Epub 2011 Apr 19. Neuropeptides. 2011. PMID: 21507484 Free PMC article.
Recently, a small 11-amino acid amidated peptide, dopamine neuron stimulating peptide-11 (DNSP-11), was shown to exert neurotrophic-like actions on primary dopaminergic neurons and in parkinsonian rat models. ...To gain insight into their biodistribution prop …
Recently, a small 11-amino acid amidated peptide, dopamine neuron stimulating peptide-11 (DNSP-11), was shown to exert …
Novel Hominid-Specific IAPP Isoforms: Potential Biomarkers of Early Alzheimer's Disease and Inhibitors of Amyloid Formation.
Liu QR, Zhu M, Chen Q, Mustapic M, Kapogiannis D, Egan JM. Liu QR, et al. Biomolecules. 2023 Jan 13;13(1):167. doi: 10.3390/biom13010167. Biomolecules. 2023. PMID: 36671553 Free PMC article.
We uncovered that IAPP(25) and a GDNF derived DNSP(11) were nonaggregating peptides that inhibited the aggregation of IAPP(37) and Abeta(42). (4) Conclusions: The novel peptides derived from hIAPP isoforms have potential to serve as blood-derived biomarkers for earl …
We uncovered that IAPP(25) and a GDNF derived DNSP(11) were nonaggregating peptides that inhibited the aggregation of IAPP(37) …