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39 results

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Page 1
Impact of DPYD, DPYS, and UPB1 gene variations on severe drug-related toxicity in patients with cancer.
Yokoi K, Nakajima Y, Matsuoka H, Shinkai Y, Ishihara T, Maeda Y, Kato T, Katsuno H, Masumori K, Kawada K, Yoshikawa T, Ito T, Kurahashi H. Yokoi K, et al. Cancer Sci. 2020 Sep;111(9):3359-3366. doi: 10.1111/cas.14553. Epub 2020 Jul 20. Cancer Sci. 2020. PMID: 32619063 Free PMC article.
Cancer treatment with a fluoropyrimidine (FP) is often accompanied by severe toxicity that may be dependent on the activity of catalytic enzymes encoded by the DPYD, DPYS, and UPB1 genes. ...To investigate the association between these genetic variations and FP-rela …
Cancer treatment with a fluoropyrimidine (FP) is often accompanied by severe toxicity that may be dependent on the activity of cataly …
The burden of rare variants in DPYS gene is a novel predictor of the risk of developing severe fluoropyrimidine-related toxicity.
De Mattia E, Polesel J, Silvestri M, Roncato R, Scarabel L, Calza S, Spina M, Puglisi F, Toffoli G, Cecchin E. De Mattia E, et al. Hum Genomics. 2023 Nov 9;17(1):99. doi: 10.1186/s40246-023-00546-9. Hum Genomics. 2023. PMID: 37946254 Free PMC article.
Some common variants with predictive value in DPYS and PPARD were also identified: DPYS rs143004875-T and PPARD rs2016520-T variants predicted an increased risk of severe cumulative (P = 0.002 and P = 0.001, respectively) and acute (P = 0.005 and P = 0.0001, respect …
Some common variants with predictive value in DPYS and PPARD were also identified: DPYS rs143004875-T and PPARD rs2016520-T va …
Stage Analysis of Breast Cancer Metabolomics: A System Biology Approach.
Hosseinpour Z, Rezaei Tavirani M, Akbari ME. Hosseinpour Z, et al. Asian Pac J Cancer Prev. 2023 May 1;24(5):1571-1582. doi: 10.31557/APJCP.2023.24.5.1571. Asian Pac J Cancer Prev. 2023. PMID: 37247276 Free PMC article.
BACKGROUND: Breast cancer (BC) is the most common malignancy in women worldwide. Altered miRNA profile can disturb the metabolic homeostatic via regulation of gene expression in BC. METHODS: In the present study to evaluate which miRNA, regulate metabolic pathways accordin …
BACKGROUND: Breast cancer (BC) is the most common malignancy in women worldwide. Altered miRNA profile can disturb the metabolic home …
Carboxylesterase 1 polymorphisms are associated with clinical outcomes in gastroenteric cancer patients treated with capecitabine.
Liu D, Li X, Li X, Wang H, Dong M. Liu D, et al. Cancer Chemother Pharmacol. 2021 May;87(5):681-687. doi: 10.1007/s00280-021-04247-9. Epub 2021 Feb 14. Cancer Chemother Pharmacol. 2021. PMID: 33586000
OBJECTIVES: The aim of this study was to test whether CES1, UMPS, DPYS and TPYS polymorphisms influence the outcomes of gastroenteric cancer patients. METHODS: We consecutively enrolled 338 patients who were diagnosed with colorectal and gastric cancer from J …
OBJECTIVES: The aim of this study was to test whether CES1, UMPS, DPYS and TPYS polymorphisms influence the outcomes of gastroenteric …
Unveiling the Role of DPYS: A New Prognostic Biomarker in Sarcoma.
Lyu G, Li D. Lyu G, et al. Curr Protein Pept Sci. 2025 Apr 4. doi: 10.2174/0113892037362065250227064739. Online ahead of print. Curr Protein Pept Sci. 2025. PMID: 40192045
BACKGROUND: Dihydropyrimidinase (DPYS), a pivotal enzyme in the pyrimidine synthesis pathway, has been increasingly studied for its potential role in cancer therapy. While its presence has been noted in various cancers, its specific impact on sarcoma (SARC) s …
BACKGROUND: Dihydropyrimidinase (DPYS), a pivotal enzyme in the pyrimidine synthesis pathway, has been increasingly studied for its p …
Identification of novel tumor markers in prostate, colon and breast cancer by unbiased methylation profiling.
Chung W, Kwabi-Addo B, Ittmann M, Jelinek J, Shen L, Yu Y, Issa JP. Chung W, et al. PLoS One. 2008 Apr 30;3(4):e2079. doi: 10.1371/journal.pone.0002079. PLoS One. 2008. PMID: 18446232 Free PMC article.
Based on methylation in primary tumors compared to normal adjacent tissues, NKX2-5, CLSTN1, SPOCK2, SLC16A12, DPYS and NSE1 are candidate biomarkers for prostate cancer (methylation range 50%-85%). ...Our data identify new targets of transcriptional silencing in …
Based on methylation in primary tumors compared to normal adjacent tissues, NKX2-5, CLSTN1, SPOCK2, SLC16A12, DPYS and NSE1 are candi …
Immune Microenvironment and Response in Prostate Cancer Using Large Population Cohorts.
Ren X, Chen X, Zhang X, Jiang S, Zhang T, Li G, Lu Z, Zhang D, Wang S, Qin C. Ren X, et al. Front Immunol. 2021 Oct 28;12:686809. doi: 10.3389/fimmu.2021.686809. eCollection 2021. Front Immunol. 2021. PMID: 34777331 Free PMC article.
Immune microenvironment of prostate cancer (PCa) is implicated in disease progression. However, previous studies have not fully explored PCa immune microenvironment. ...On the other hand, patients in IRScluster2 showed better prognosis and low immunotherapy response rate. …
Immune microenvironment of prostate cancer (PCa) is implicated in disease progression. However, previous studies have not fully explo …
Contribution of dihydropyrimidinase gene alterations to the development of serious toxicity in fluoropyrimidine-treated cancer patients.
Fidlerova J, Kleiblova P, Bilek M, Kormunda S, Formankova Z, Novotny J, Kleibl Z. Fidlerova J, et al. Cancer Chemother Pharmacol. 2010 Mar;65(4):661-9. doi: 10.1007/s00280-009-1071-0. Epub 2009 Aug 1. Cancer Chemother Pharmacol. 2010. PMID: 19649633
METHODS: We performed genotyping of DPYS based on denaturing high-performance liquid chromatography in 113 cancer patients including 67 with severe FP-related toxicity and 46 without toxicity excellently tolerating FPs treatment. ...CONCLUSIONS: Our results indicate …
METHODS: We performed genotyping of DPYS based on denaturing high-performance liquid chromatography in 113 cancer patients inc …
Examination of whole blood DNA methylation as a potential risk marker for gastric cancer.
Tahara T, Maegawa S, Chung W, Garriga J, Jelinek J, Estécio MR, Shibata T, Hirata I, Arisawa T, Issa JP. Tahara T, et al. Cancer Prev Res (Phila). 2013 Oct;6(10):1093-100. doi: 10.1158/1940-6207.CAPR-13-0034. Epub 2013 Aug 13. Cancer Prev Res (Phila). 2013. PMID: 23943784 Free PMC article.
Bisulfite pyrosequencing was used to quantify the methylation of 14 CpG island promoters (MINT25, RORA, GDNF, CDH1, RARAB2, ER, CDH13, MYOD1, SFRP1, P2RX7, SLC16A12, IGF2, DPYS, and N33) and LINE1 from 72 patients with gastric cancer, 67 control, and 52 healthy youn …
Bisulfite pyrosequencing was used to quantify the methylation of 14 CpG island promoters (MINT25, RORA, GDNF, CDH1, RARAB2, ER, CDH13, MYOD1 …
HTR2B as a novel biomarker of chronic obstructive pulmonary disease with lung squamous cell carcinoma.
Li Y, Wang Y, Wu R, Li P, Cheng Z. Li Y, et al. Sci Rep. 2024 Jun 8;14(1):13206. doi: 10.1038/s41598-024-63896-x. Sci Rep. 2024. PMID: 38851806 Free PMC article.
Smoking, inflammation, and airway remodeling are the most important and classical mechanisms of COPD comorbidity in LUSC patients. Cancer can occur during repeated airway damage and repair (airway remodeling). Changes in the inflammatory and immune microenvironments, which …
Smoking, inflammation, and airway remodeling are the most important and classical mechanisms of COPD comorbidity in LUSC patients. Cancer …
39 results