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Page 1
Desmocollin-3 and Bladder Cancer.
Shukla CP, Jain NK, O'Donnell MA, Vachhani KV, Patel R, Patel J, Modi R, Dheeraj A, Lee JM, Rolig A, Malhotra SV, Khamar B. Shukla CP, et al. Diseases. 2025 Apr 23;13(5):131. doi: 10.3390/diseases13050131. Diseases. 2025. PMID: 40422563 Free PMC article.
BACKGROUND: Desmocollin3, a transmembrane protein, is expressed in the basal/suprabasal layer of normal stratified epithelium. DSC3 gene expression is described in muscle-invasive bladder cancer (MIBC). DSC3-protein-expressing recurrent non-muscle-invasive bl …
BACKGROUND: Desmocollin3, a transmembrane protein, is expressed in the basal/suprabasal layer of normal stratified epithelium. DSC3 g …
Association of DSC3 mRNA down-regulation in prostate cancer with promoter hypermethylation and poor prognosis.
Pan J, Chen Y, Mo C, Wang D, Chen J, Mao X, Guo S, Zhuang J, Qiu S. Pan J, et al. PLoS One. 2014 Mar 24;9(3):e92815. doi: 10.1371/journal.pone.0092815. eCollection 2014. PLoS One. 2014. PMID: 24664224 Free PMC article. Clinical Trial.
BACKGROUND: Desmocollin 3 (DSC3), a member of the cadherin gene superfamily, is associated with pathogenesis of some cancers, but its role in prostate cancer (PCa) remains largely unknown. ...CONCLUSION: Taken together, our data suggests that DNA methylation …
BACKGROUND: Desmocollin 3 (DSC3), a member of the cadherin gene superfamily, is associated with pathogenesis of some cancers, …
Epigenetic silencing of DSC3 is a common event in human breast cancer.
Oshiro MM, Kim CJ, Wozniak RJ, Junk DJ, Muñoz-Rodríguez JL, Burr JA, Fitzgerald M, Pawar SC, Cress AE, Domann FE, Futscher BW. Oshiro MM, et al. Breast Cancer Res. 2005;7(5):R669-80. doi: 10.1186/bcr1273. Epub 2005 Jun 16. Breast Cancer Res. 2005. PMID: 16168112 Free PMC article.
DSC3 expression is down-regulated in breast cancer cell lines and primary breast tumors; however, the loss of DSC3 is not due to gene deletion or gross rearrangement of the gene. ...We also used a quantitative real-time RT-PCR approach, and analyzed all breas …
DSC3 expression is down-regulated in breast cancer cell lines and primary breast tumors; however, the loss of DSC3 is n …
DSC3 expression is regulated by p53, and methylation of DSC3 DNA is a prognostic marker in human colorectal cancer.
Cui T, Chen Y, Yang L, Knösel T, Zöller K, Huber O, Petersen I. Cui T, et al. Br J Cancer. 2011 Mar 15;104(6):1013-9. doi: 10.1038/bjc.2011.28. Epub 2011 Mar 1. Br J Cancer. 2011. PMID: 21364582 Free PMC article.
However, the role of DSC3 in colorectal cancer (CRC) has not yet been established. METHODS: Desmocollin 3 expression in CRC cell lines was analysed by RT-PCR and western blotting. ...CONCLUSIONS: DNA methylation contributes to downregulation of DSC3 in CRC ce …
However, the role of DSC3 in colorectal cancer (CRC) has not yet been established. METHODS: Desmocollin 3 expression in CRC ce …
Autoantibodies to DSC3 in Pemphigus Exclusively Recognize Calcium-Dependent Epitope in Extracellular Domain 2.
Koga H, Teye K, Otsuji Y, Ishii N, Hashimoto T, Nakama T. Koga H, et al. J Invest Dermatol. 2021 Sep;141(9):2123-2131.e2. doi: 10.1016/j.jid.2021.01.032. Epub 2021 Mar 22. J Invest Dermatol. 2021. PMID: 33766509 Free article.
We aimed to analyze the characteristics of anti-DSC3 antibodies using DSC3 domain-swapped desmoglein 2 molecules in which the prosequence and five extracellular (EC) domains of desmoglein 2 were replaced with the corresponding domains of human DSC3. ...In the …
We aimed to analyze the characteristics of anti-DSC3 antibodies using DSC3 domain-swapped desmoglein 2 molecules in which the …
Desmocollin 3 has a tumor suppressive activity through inhibition of AKT pathway in colorectal cancer.
Cui T, Yang L, Ma Y, Petersen I, Chen Y. Cui T, et al. Exp Cell Res. 2019 May 15;378(2):124-130. doi: 10.1016/j.yexcr.2019.03.015. Epub 2019 Mar 8. Exp Cell Res. 2019. PMID: 30857973
Desmocollin 3 (DSC3) is a transmembrane adhesion protein of desmosomes and involved in carcinogenesis in various cancer types. Downregulation of DSC3 has been reported in colorectal cancer (CRC). However, the function of DSC3 in CRC has not yet …
Desmocollin 3 (DSC3) is a transmembrane adhesion protein of desmosomes and involved in carcinogenesis in various cancer types. …
Systemic analysis of the expression levels and prognosis of breast cancer-related cadherins.
Xu M, Liu C, Pu L, Lai J, Li J, Ning Q, Liu X, Deng S. Xu M, et al. Exp Biol Med (Maywood). 2021 Aug;246(15):1706-1720. doi: 10.1177/15353702211010417. Epub 2021 Apr 25. Exp Biol Med (Maywood). 2021. PMID: 33899544 Free PMC article.
We found that the CDH2/11 levels were higher in breast cancer tissues, compared to healthy breast tissues, whereas with CDH3-5, PCDH8/10, and DSC3, the levels were lower in the former than in the latter. ...These data suggest CDH1-3 to be a promising target for brea …
We found that the CDH2/11 levels were higher in breast cancer tissues, compared to healthy breast tissues, whereas with CDH3-5, PCDH8 …
Diagnostic and prognostic impact of desmocollins in human lung cancer.
Cui T, Chen Y, Yang L, Mireskandari M, Knösel T, Zhang Q, Kohler LH, Kunze A, Presselt N, Petersen I. Cui T, et al. J Clin Pathol. 2012 Dec;65(12):1100-6. doi: 10.1136/jclinpath-2011-200630. Epub 2012 Sep 21. J Clin Pathol. 2012. PMID: 23002285
A heterogeneous methylation pattern was detected by bisulphite sequencing in exon 1 of DSC2 and DSC3. In 199 patients with primary lung cancer, we found that lower protein expression of DSC1 was significantly linked to worse tumour differentiation (p=0.017), DSC3 …
A heterogeneous methylation pattern was detected by bisulphite sequencing in exon 1 of DSC2 and DSC3. In 199 patients with primary lu …
The p53 target gene desmocollin 3 acts as a novel tumor suppressor through inhibiting EGFR/ERK pathway in human lung cancer.
Cui T, Chen Y, Yang L, Knösel T, Huber O, Pacyna-Gengelbach M, Petersen I. Cui T, et al. Carcinogenesis. 2012 Dec;33(12):2326-33. doi: 10.1093/carcin/bgs273. Epub 2012 Aug 31. Carcinogenesis. 2012. PMID: 22941060
It turned out that downregulation of DSC3 in lung cancer cells was associated with DNA hypermethylation. In primary lung tumors, DSC3 was a potential diagnostic marker for lung squamous cell carcinoma, and DSC3 DNA hypermethylation was correlated with …
It turned out that downregulation of DSC3 in lung cancer cells was associated with DNA hypermethylation. In primary lung tumor …
Desmocollin switching in colorectal cancer.
Khan K, Hardy R, Haq A, Ogunbiyi O, Morton D, Chidgey M. Khan K, et al. Br J Cancer. 2006 Nov 20;95(10):1367-70. doi: 10.1038/sj.bjc.6603453. Epub 2006 Oct 31. Br J Cancer. 2006. PMID: 17088906 Free PMC article.
In humans, three desmocollins (Dsc1, Dsc2 and Dsc3) have been described. The desmocollins exhibit tissue-specific patterns of expression; only Dsc2 is expressed in normal colonic epithelium. ...Loss of Dsc2 (8/19) and de novo expression of Dsc1 (11/19) and Dsc3 (6/1 …
In humans, three desmocollins (Dsc1, Dsc2 and Dsc3) have been described. The desmocollins exhibit tissue-specific patterns of express …
72 results