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Inhibiting insulin resistance mechanisms by DTS phytocompound: an experimental study on metabolic syndrome-prone adipocytes.
Catanzaro R, Lorenzetti A, Allegri F, Yadav H, Solimene U, Kumaraju AK, Minelli E, Tomella C, Polimeni A, Marotta F. Catanzaro R, et al. Acta Biomed. 2012 Aug;83(2):95-102. Acta Biomed. 2012. PMID: 23393916
The production of NO was decreased by 52% at the concentration of 30mM of DTS. The decrease in NO production by DTS was associated also with a decrease in inducible nitric oxide synthase (iNOS) protein and iNOS mRNA expression. Nuclear factor-kappa B (NF-kappaB) was …
The production of NO was decreased by 52% at the concentration of 30mM of DTS. The decrease in NO production by DTS was associ …
Redox status impairment in liver and kidney of prematurely senescent mice: effectiveness of DTS phytotherapeutic compound.
Marotta F, Lorenzetti F, Harada M, Ono-Nita SK, Minelli E, Marandola P. Marotta F, et al. Ann N Y Acad Sci. 2006 May;1067:408-13. doi: 10.1196/annals.1354.058. Ann N Y Acad Sci. 2006. PMID: 16804019
T-maze test-selected prematurely senescent mice (PSM) were allocated into two groups: (A) those given DTS (150 mg/kg) orally for 30 days and (B) untreated PSM with age-matched fast T-maze performers as control. ...Such preliminary data suggest that DTS mitigated oxi …
T-maze test-selected prematurely senescent mice (PSM) were allocated into two groups: (A) those given DTS (150 mg/kg) orally for 30 d …
A phytochemical approach to experimental metabolic syndrome-associated renal damage and oxidative stress.
Marotta F, Kumari A, Catanzaro R, Solimene U, Jain S, Minelli E, Harada M. Marotta F, et al. Rejuvenation Res. 2012 Apr;15(2):153-6. doi: 10.1089/rej.2011.1266. Rejuvenation Res. 2012. PMID: 22533421
The aim of this study was to evaluate the effect of DTS-phytocompound on oxidant-antioxidant balance and protein damage in the kidneys of rats administered high doses of fructose. ...These data suggest the potential clinical benefit of DTS in protecting the kidneys …
The aim of this study was to evaluate the effect of DTS-phytocompound on oxidant-antioxidant balance and protein damage in the kidney …
Beneficial modification of functional renal parameters in 5/6 nephrectomized rats by nutraceutical. In view of a kidney-protective intervention.
Harada M, Sweed H, Catanzaro R, Kumari A, Bomba A, Minelli E, Polimeni A, Solimene U, Marotta F. Harada M, et al. Acta Biomed. 2011 Dec;82(3):200-7. Acta Biomed. 2011. PMID: 22783716 Free article.
Rats in Group A and Group B were fed with a normal protein diet only while those in Group C were fed normal protein diet added with DTS (10 mg/rat/day). The DTS supplementation was started a day after surgery. ...In contrast, plasma urea concentration and morphologi …
Rats in Group A and Group B were fed with a normal protein diet only while those in Group C were fed normal protein diet added with DTS
Progression of atherosclerotic lesions in the arteries and related gene expression: protective effect of phytonutrients.
Marotta F, Harada M, Minelli E, Yadav H, Polimeni A, Lorenzetti A, Locorotondo N. Marotta F, et al. Rejuvenation Res. 2010 Apr-Jun;13(2-3):242-5. doi: 10.1089/rej.2009.0949. Rejuvenation Res. 2010. PMID: 20370493
We investigated the effect of the phytocompound Denshici-to-Chiusei (DTS) on the atherogenesis in apolipoprotein E(-/-)/low-density lipoprotein receptor(-/-) (apoE(-/-)/LDL receptor(-/-)) mice (E0). ...Tumor necrosis factor-alpha (TNF-alpha) expression and immunoreactivity …
We investigated the effect of the phytocompound Denshici-to-Chiusei (DTS) on the atherogenesis in apolipoprotein E(-/-)/low-density l …
Protective effect of a poly-phytocompound on early stage nephropathy secondary to experimentally-induced diabetes.
Marotta F, Harada M, Dallah ED, Yadav H, Solimene U, Di Lembo S, Minelli E, Jain S, Chui DH. Marotta F, et al. J Biol Regul Homeost Agents. 2010 Jan-Mar;24(1):41-9. J Biol Regul Homeost Agents. 2010. PMID: 20385070 Free article.
Histological analysis showed also that DTS significantly reduced the glomerular volume together with glomerulosclerosis and interstitial fibrosis score (p less than 0.05), the latter two being correlated to proteinuria (p less than 0.05). DTS supplementation also en …
Histological analysis showed also that DTS significantly reduced the glomerular volume together with glomerulosclerosis and interstit …
"Accelerating aging" chemotherapy on aged animals: protective effect from nutraceutical modulation.
Marotta F, Harada M, Minelli E, Ono-Nita SK, Marandola P. Marotta F, et al. Rejuvenation Res. 2008 Apr;11(2):513-7. doi: 10.1089/rej.2008.0681. Rejuvenation Res. 2008. PMID: 18442331

CPX significantly decreased macrophage chemotaxis and all cytokines (p < 0.05, A >> Y). DTS restored macrophage function and cytokine concentration (p < 0.001) and partly improved the necro-inflammatory score and substance P receptor expression in the bladder a

CPX significantly decreased macrophage chemotaxis and all cytokines (p < 0.05, A >> Y). DTS restored macrophage function and

Protective effect of a phytocompound on oxidative stress and DNA fragmentation against paracetamol-induced liver damage.
Marotta F, Yadav H, Gumaste U, Helmy A, Jain S, Minelli E. Marotta F, et al. Ann Hepatol. 2009 Jan-Mar;8(1):50-6. Ann Hepatol. 2009. PMID: 19221534 Free article.
The hepatoprotective potential DTS (1.5 g/kg bw, Denshici-to-Chiusei, Kyotsu Jigyo, Tokyo, Japan) was evaluated against either toxic (1.5 g/kg bw) and sub-toxic (150 mg/kg bw) dosage of paracetamol-induced liver injury in Sprague-Dawley rat. ...Moreover, DTS partly …
The hepatoprotective potential DTS (1.5 g/kg bw, Denshici-to-Chiusei, Kyotsu Jigyo, Tokyo, Japan) was evaluated against either toxic …