Daggett L - Search Results

1

3-(2-Ethoxy-4-{4-[3-hydroxy-2-methyl-4-(3-methylbutanoyl)phenoxy]butoxy}phenyl)propanoic acid: a brain penetrant allosteric potentiator at the metabotropic glutamate receptor 2 (mGluR2).

Cube RV, Vernier JM, Hutchinson JH, Gardner MF, James JK, Rowe BA, Schaffhauser H, Daggett L, Pinkerton AB. Cube RV, et al. Among authors: daggett l. Bioorg Med Chem Lett. 2005 May 2;15(9):2389-93. doi: 10.1016/j.bmcl.2005.02.078. Bioorg Med Chem Lett. 2005. PMID: 15837331

2

Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2.

Schaffhauser H, Rowe BA, Morales S, Chavez-Noriega LE, Yin R, Jachec C, Rao SP, Bain G, Pinkerton AB, Vernier JM, Bristow LJ, Varney MA, Daggett LP. Schaffhauser H, et al. Mol Pharmacol. 2003 Oct;64(4):798-810. doi: 10.1124/mol.64.4.798. Mol Pharmacol. 2003. PMID: 14500736

3

Phenyl-tetrazolyl acetophenones: discovery of positive allosteric potentiatiors for the metabotropic glutamate 2 receptor.

Pinkerton AB, Vernier JM, Schaffhauser H, Rowe BA, Campbell UC, Rodriguez DE, Lorrain DS, Baccei CS, Daggett LP, Bristow LJ. Pinkerton AB, et al. J Med Chem. 2004 Aug 26;47(18):4595-9. doi: 10.1021/jm040088h. J Med Chem. 2004. PMID: 15317469

4

Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 1: Identification and synthesis of phenyl-tetrazolyl acetophenones.

Pinkerton AB, Cube RV, Hutchinson JH, Rowe BA, Schaffhauser H, Zhao X, Daggett LP, Vernier JM. Pinkerton AB, et al. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5329-32. doi: 10.1016/j.bmcl.2004.08.020. Bioorg Med Chem Lett. 2004. PMID: 15454221

5

Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 2: 4-thiopyridyl acetophenones as non-tetrazole containing mGlu2 receptor potentiators.

Pinkerton AB, Cube RV, Hutchinson JH, James JK, Gardner MF, Schaffhauser H, Rowe BA, Daggett LP, Vernier JM. Pinkerton AB, et al. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5867-72. doi: 10.1016/j.bmcl.2004.09.028. Bioorg Med Chem Lett. 2004. PMID: 15501058

6

Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 3: Identification and biological activity of indanone containing mGlu2 receptor potentiators.

Pinkerton AB, Cube RV, Hutchinson JH, James JK, Gardner MF, Rowe BA, Schaffhauser H, Rodriguez DE, Campbell UC, Daggett LP, Vernier JM. Pinkerton AB, et al. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1565-71. doi: 10.1016/j.bmcl.2005.01.077. Bioorg Med Chem Lett. 2005. PMID: 15745798

7

Benzazoles as allosteric potentiators of metabotropic glutamate receptor 2 (mGluR2): efficacy in an animal model for schizophrenia.

Govek SP, Bonnefous C, Hutchinson JH, Kamenecka T, McQuiston J, Pracitto R, Zhao LX, Gardner MF, James JK, Daggett LP, Rowe BA, Schaffhauser H, Bristow LJ, Campbell UC, Rodriguez DE, Vernier JM. Govek SP, et al. Among authors: daggett lp. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4068-72. doi: 10.1016/j.bmcl.2005.06.017. Bioorg Med Chem Lett. 2005. PMID: 16005222

8

Biphenyl-indanones: allosteric potentiators of the metabotropic glutamate subtype 2 receptor.

Bonnefous C, Vernier JM, Hutchinson JH, Gardner MF, Cramer M, James JK, Rowe BA, Daggett LP, Schaffhauser H, Kamenecka TM. Bonnefous C, et al. Among authors: daggett lp. Bioorg Med Chem Lett. 2005 Oct 1;15(19):4354-8. doi: 10.1016/j.bmcl.2005.06.062. Bioorg Med Chem Lett. 2005. PMID: 16046122

9

Transposition of three amino acids transforms the human metabotropic glutamate receptor (mGluR)-3-positive allosteric modulation site to mGluR2, and additional characterization of the mGluR2-positive allosteric modulation site.

Rowe BA, Schaffhauser H, Morales S, Lubbers LS, Bonnefous C, Kamenecka TM, McQuiston J, Daggett LP. Rowe BA, et al. Among authors: daggett lp. J Pharmacol Exp Ther. 2008 Jul;326(1):240-51. doi: 10.1124/jpet.108.138271. Epub 2008 Apr 22. J Pharmacol Exp Ther. 2008. PMID: 18430863

10

Distribution of metabotropic glutamate 2 and 3 receptors in the rat forebrain: Implication in emotional responses and central disinhibition.

Gu G, Lorrain DS, Wei H, Cole RL, Zhang X, Daggett LP, Schaffhauser HJ, Bristow LJ, Lechner SM. Gu G, et al. Among authors: daggett lp. Brain Res. 2008 Mar 4;1197:47-62. doi: 10.1016/j.brainres.2007.12.057. Epub 2008 Jan 3. Brain Res. 2008. PMID: 18242587

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