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Antigen processing patterns determine GAD65-specific regulation vs. pathogenesis.
Dai YD, Sercarz EE. Dai YD, et al. Front Biosci (Landmark Ed). 2009 Jan 1;14:344-51. doi: 10.2741/3248. Front Biosci (Landmark Ed). 2009. PMID: 19273071 Review.
Antigen processing by autoreactive B cells promotes determinant spreading.
Dai YD, Carayanniotis G, Sercarz E. Dai YD, et al. Cell Mol Immunol. 2005 Jun;2(3):169-75. Cell Mol Immunol. 2005. PMID: 16212883 Review.
N-terminal flanking residues of a diabetes-associated GAD65 determinant are necessary for activation of antigen-specific T cells in diabetes-resistant mice.
Dai YD, Jensen KP, Marrero I, Li N, Quinn A, Sercarz EE. Dai YD, et al. Eur J Immunol. 2008 Apr;38(4):968-76. doi: 10.1002/eji.200737703. Eur J Immunol. 2008. PMID: 18395850
Slc11a1 enhances the autoimmune diabetogenic T-cell response by altering processing and presentation of pancreatic islet antigens.
Dai YD, Marrero IG, Gros P, Zaghouani H, Wicker LS, Sercarz EE. Dai YD, et al. Diabetes. 2009 Jan;58(1):156-64. doi: 10.2337/db07-1608. Epub 2008 Nov 4. Diabetes. 2009. PMID: 18984740 Free PMC article.
Oligoclonality and innate-like features in the TCR repertoire of type II NKT cells reactive to a beta-linked self-glycolipid.
Arrenberg P, Halder R, Dai Y, Maricic I, Kumar V. Arrenberg P, et al. Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):10984-9. doi: 10.1073/pnas.1000576107. Epub 2010 Jun 1. Proc Natl Acad Sci U S A. 2010. PMID: 20534460 Free PMC article.
Insulinoma-released exosomes or microparticles are immunostimulatory and can activate autoreactive T cells spontaneously developed in nonobese diabetic mice.
Sheng H, Hassanali S, Nugent C, Wen L, Hamilton-Williams E, Dias P, Dai YD. Sheng H, et al. J Immunol. 2011 Aug 15;187(4):1591-600. doi: 10.4049/jimmunol.1100231. Epub 2011 Jul 6. J Immunol. 2011. PMID: 21734072 Free PMC article.
Insulinoma-released exosomes activate autoreactive marginal zone-like B cells that expand endogenously in prediabetic NOD mice.
Bashratyan R, Sheng H, Regn D, Rahman MJ, Dai YD. Bashratyan R, et al. Eur J Immunol. 2013 Oct;43(10):2588-97. doi: 10.1002/eji.201343376. Epub 2013 Aug 1. Eur J Immunol. 2013. PMID: 23817982 Free PMC article.
Type 1 diabetes pathogenesis is modulated by spontaneous autoimmune responses to endogenous retrovirus antigens in NOD mice.
Bashratyan R, Regn D, Rahman MJ, Marquardt K, Fink E, Hu WY, Elder JH, Binley J, Sherman LA, Dai YD. Bashratyan R, et al. Eur J Immunol. 2017 Mar;47(3):575-584. doi: 10.1002/eji.201646755. Epub 2017 Feb 6. Eur J Immunol. 2017. PMID: 28083937
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