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A low expressor line of transgenic mice carrying a mutant human Cu,Zn superoxide dismutase (SOD1) gene develops pathological changes that most closely resemble those in human amyotrophic lateral sclerosis.
Dal Canto MC, Gurney ME. Dal Canto MC, et al. Acta Neuropathol. 1997 Jun;93(6):537-50. doi: 10.1007/s004010050650. Acta Neuropathol. 1997. PMID: 9194892
Anticapsid immunity level, not viral persistence level, correlates with the progression of Theiler's virus-induced demyelinating disease in viral P1-transgenic mice.
Myoung J, Bahk YY, Kang HS, Dal Canto MC, Kim BS. Myoung J, et al. Among authors: dal canto mc. J Virol. 2008 Jun;82(11):5606-17. doi: 10.1128/JVI.02442-07. Epub 2008 Mar 19. J Virol. 2008. PMID: 18353953 Free PMC article.
Astrocytes, not microglia, are the main cells responsible for viral persistence in Theiler's murine encephalomyelitis virus infection leading to demyelination.
Zheng L, Calenoff MA, Dal Canto MC. Zheng L, et al. J Neuroimmunol. 2001 Aug 30;118(2):256-67. doi: 10.1016/s0165-5728(01)00338-1. J Neuroimmunol. 2001. PMID: 11498260
Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation.
Gurney ME, Pu H, Chiu AY, Dal Canto MC, Polchow CY, Alexander DD, Caliendo J, Hentati A, Kwon YW, Deng HX, et al. Gurney ME, et al. Science. 1994 Jun 17;264(5166):1772-5. doi: 10.1126/science.8209258. Science. 1994. PMID: 8209258
Neuropathological changes in two lines of mice carrying a transgene for mutant human Cu,Zn SOD, and in mice overexpressing wild type human SOD: a model of familial amyotrophic lateral sclerosis (FALS).
Dal Canto MC, Gurney ME. Dal Canto MC, et al. Brain Res. 1995 Apr 3;676(1):25-40. doi: 10.1016/0006-8993(95)00063-v. Brain Res. 1995. PMID: 7796176
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