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Anxiety, defence and the elevated plus-maze.
Rodgers RJ, Dalvi A. Rodgers RJ, et al. Among authors: dalvi a. Neurosci Biobehav Rev. 1997 Nov;21(6):801-10. doi: 10.1016/s0149-7634(96)00058-9. Neurosci Biobehav Rev. 1997. PMID: 9415905 Review.
The elevated plus-maze test has been in use as a rodent model of anxiety for a decade, and is representative of those tests that are based upon the study of spontaneous behaviour patterns and which have high ecological validity. ...It is concluded that, when used ap …
The elevated plus-maze test has been in use as a rodent model of anxiety for a decade, and is representative of those tests th …
Anxiolytic effects of valproate and diazepam in mice are differentially sensitive to picrotoxin antagonism.
Dalvi A, Rodgers RJ. Dalvi A, et al. Pharmacol Biochem Behav. 2001 Jan;68(1):23-32. doi: 10.1016/s0091-3057(00)00408-1. Pharmacol Biochem Behav. 2001. PMID: 11274704
Although it is widely believed that the anxiolytic effects of benzodiazepines are mediated through facilitation of GABA(A) receptor function, behavioural studies have to date provided rather weak support for this hypothesis. ...These data suggest that the plus-maze anxioly …
Although it is widely believed that the anxiolytic effects of benzodiazepines are mediated through facilitation of GABA(A) receptor f …
Behavioral effects of diazepam in the murine plus-maze: flumazenil antagonism of enhanced head dipping but not the disinhibition of open-arm avoidance.
Dalvi A, Rodgers RJ. Dalvi A, et al. Pharmacol Biochem Behav. 1999 Apr;62(4):727-34. doi: 10.1016/s0091-3057(98)00220-2. Pharmacol Biochem Behav. 1999. PMID: 10208379
Although it is widely believed that benzodiazepines reduce anxiety through positive allosteric modulation of the GABA(A)-chloride channel complex, this is not the only mechanism through which agents of this class can modify CNS function. Furthermore, a significant n …
Although it is widely believed that benzodiazepines reduce anxiety through positive allosteric modulation of the GABA(A)-chloride cha …
GABAergic influences on plus-maze behaviour in mice.
Dalvi A, Rodgers RJ. Dalvi A, et al. Psychopharmacology (Berl). 1996 Dec;128(4):380-97. doi: 10.1007/s002130050148. Psychopharmacology (Berl). 1996. PMID: 8986009
In the present series, an ethological version of the murine elevated plus-maze was used to examine in detail the behavioural profiles of diazepam (1.5 mg/kg; positive control) and a range of GABA-related compounds: valproic acid (100-400 mg/kg), No-711 (1.25-10.0 mg/kg), m …
In the present series, an ethological version of the murine elevated plus-maze was used to examine in detail the behavioural profiles of dia …
Animal models of anxiety: an ethological perspective.
Rodgers RJ, Cao BJ, Dalvi A, Holmes A. Rodgers RJ, et al. Among authors: dalvi a. Braz J Med Biol Res. 1997 Mar;30(3):289-304. doi: 10.1590/s0100-879x1997000300002. Braz J Med Biol Res. 1997. PMID: 9246227 Review.
However, a solely pharmacological approach to the validation of such tests has resulted in distinct problems with their applicability to systems other than those involving the benzodiazepine/GABAA receptor complex. ...This fresh approach to an established test has revealed …
However, a solely pharmacological approach to the validation of such tests has resulted in distinct problems with their applicability …
Acceleration of onset of action in schedule-induced polydipsia: combinations of SSRI and 5-HT1A and 5-HT1B receptor antagonists.
Hogg S, Dalvi A. Hogg S, et al. Among authors: dalvi a. Pharmacol Biochem Behav. 2004 Jan;77(1):69-75. doi: 10.1016/j.pbb.2003.09.020. Pharmacol Biochem Behav. 2004. PMID: 14724043
Onset of action is a key unmet need in the treatment of depression. However, very few preclinical models in which the effects of antidepressants can be shown are suitable for screening for onset. In this context, previous literature suggests that a slow onset of act …
Onset of action is a key unmet need in the treatment of depression. However, very few preclinical models in which the effects of anti …
Sensitivity to the effects of pharmacologically selective antidepressants in different strains of mice.
Lucki I, Dalvi A, Mayorga AJ. Lucki I, et al. Among authors: dalvi a. Psychopharmacology (Berl). 2001 May;155(3):315-22. doi: 10.1007/s002130100694. Psychopharmacology (Berl). 2001. PMID: 11432695
A comprehensive comparison of inbred and outbred mouse strains was conducted to provide information on the range of performance and pharmacological effects in the forced swimming test, a behavioral test commonly used to measure the effects of antidepressant drugs. O
A comprehensive comparison of inbred and outbred mouse strains was conducted to provide information on the range of performance and p
Antidepressant-like behavioral effects in 5-hydroxytryptamine(1A) and 5-hydroxytryptamine(1B) receptor mutant mice.
Mayorga AJ, Dalvi A, Page ME, Zimov-Levinson S, Hen R, Lucki I. Mayorga AJ, et al. Among authors: dalvi a. J Pharmacol Exp Ther. 2001 Sep;298(3):1101-7. J Pharmacol Exp Ther. 2001. PMID: 11504807
Serotonergic mediation of the effects of fluoxetine, but not desipramine, in the rat forced swimming test.
Page ME, Detke MJ, Dalvi A, Kirby LG, Lucki I. Page ME, et al. Among authors: dalvi a. Psychopharmacology (Berl). 1999 Nov;147(2):162-7. doi: 10.1007/s002130051156. Psychopharmacology (Berl). 1999. PMID: 10591883
RATIONALE: The forced swimming test (FST) is a behavioral test in rodents that predicts the clinical efficacy of many types of antidepressant treatments. Recently, a behavior sampling technique was developed that scores individual response categories, including swim …
RATIONALE: The forced swimming test (FST) is a behavioral test in rodents that predicts the clinical efficacy of many types of antide …
Use of dopamine-beta-hydroxylase-deficient mice to determine the role of norepinephrine in the mechanism of action of antidepressant drugs.
Cryan JF, Dalvi A, Jin SH, Hirsch BR, Lucki I, Thomas SA. Cryan JF, et al. Among authors: dalvi a. J Pharmacol Exp Ther. 2001 Aug;298(2):651-7. J Pharmacol Exp Ther. 2001. PMID: 11454927
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