Dambach D - Search Results

1

Integrated risk assessment of suicidal ideation and behavior in drug development.

Muller PY, Dambach D, Gemzik B, Hartmann A, Ratcliffe S, Trendelenburg C, Urban L. Muller PY, et al. Among authors: dambach d. Drug Discov Today. 2015 Sep;20(9):1135-42. doi: 10.1016/j.drudis.2015.05.010. Epub 2015 May 27. Drug Discov Today. 2015. PMID: 26022402 Review.

2

Improving risk assessment.

Dambach DM, Uppal H. Dambach DM, et al. Sci Transl Med. 2012 Nov 7;4(159):159ps22. doi: 10.1126/scitranslmed.3003497. Sci Transl Med. 2012. PMID: 23136041

3

A retrospective analysis of toxicogenomics in the safety assessment of drug candidates.

Foster WR, Chen SJ, He A, Truong A, Bhaskaran V, Nelson DM, Dambach DM, Lehman-McKeeman LD, Car BD. Foster WR, et al. Among authors: dambach dm. Toxicol Pathol. 2007 Aug;35(5):621-35. doi: 10.1080/01926230701419063. Toxicol Pathol. 2007. PMID: 17654404 Review.

4

New technologies and screening strategies for hepatotoxicity: use of in vitro models.

Dambach DM, Andrews BA, Moulin F. Dambach DM, et al. Toxicol Pathol. 2005;33(1):17-26. doi: 10.1080/01926230590522284. Toxicol Pathol. 2005. PMID: 15805052 Review.

5

Safety Lead Optimization and Candidate Identification: Integrating New Technologies into Decision-Making.

Dambach DM, Misner D, Brock M, Fullerton A, Proctor W, Maher J, Lee D, Ford K, Diaz D. Dambach DM, et al. Chem Res Toxicol. 2016 Apr 18;29(4):452-72. doi: 10.1021/acs.chemrestox.5b00396. Epub 2015 Dec 16. Chem Res Toxicol. 2016. PMID: 26625186 Review.

6

Current nonclinical testing paradigm enables safe entry to First-In-Human clinical trials: The IQ consortium nonclinical to clinical translational database.

Monticello TM, Jones TW, Dambach DM, Potter DM, Bolt MW, Liu M, Keller DA, Hart TK, Kadambi VJ. Monticello TM, et al. Among authors: dambach dm. Toxicol Appl Pharmacol. 2017 Nov 1;334:100-109. doi: 10.1016/j.taap.2017.09.006. Epub 2017 Sep 8. Toxicol Appl Pharmacol. 2017. PMID: 28893587

7

Computational predictions of the site of metabolism of cytochrome P450 2D6 substrates: comparative analysis, molecular docking, bioactivation and toxicological implications.

Ford KA, Ryslik G, Sodhi J, Halladay J, Diaz D, Dambach D, Masuda M. Ford KA, et al. Among authors: dambach d. Drug Metab Rev. 2015 Aug;47(3):291-319. doi: 10.3109/03602532.2015.1047026. Epub 2015 May 29. Drug Metab Rev. 2015. PMID: 26024250 Review.

8

Identification of in vitro protein biomarkers of idiosyncratic liver toxicity.

Gao J, Ann Garulacan L, Storm SM, Hefta SA, Opiteck GJ, Lin JH, Moulin F, Dambach DM. Gao J, et al. Toxicol In Vitro. 2004 Aug;18(4):533-41. doi: 10.1016/j.tiv.2004.01.012. Toxicol In Vitro. 2004. PMID: 15130611

9

Key Challenges and Opportunities Associated with the Use of In Vitro Models to Detect Human DILI: Integrated Risk Assessment and Mitigation Plans.

Atienzar FA, Blomme EA, Chen M, Hewitt P, Kenna JG, Labbe G, Moulin F, Pognan F, Roth AB, Suter-Dick L, Ukairo O, Weaver RJ, Will Y, Dambach DM. Atienzar FA, et al. Among authors: dambach dm. Biomed Res Int. 2016;2016:9737920. doi: 10.1155/2016/9737920. Epub 2016 Sep 5. Biomed Res Int. 2016. PMID: 27689095 Free PMC article. Review.

10

Nonclinical Evaluations of Small-Molecule Oncology Drugs: Integration into Clinical Dose Optimization and Toxicity Management.

Dambach DM, Simpson NE, Jones TW, Brennan RJ, Pazdur R, Palmby TR. Dambach DM, et al. Clin Cancer Res. 2016 Jun 1;22(11):2618-22. doi: 10.1158/1078-0432.CCR-15-2645. Clin Cancer Res. 2016. PMID: 27250932

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