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The controversial world of sirtuins.
Dang W. Dang W. Drug Discov Today Technol. 2014 Jun;12:e9-e17. doi: 10.1016/j.ddtec.2012.08.003. Drug Discov Today Technol. 2014. PMID: 25027380 Free PMC article. Review.
H3K36 methylation promotes longevity by enhancing transcriptional fidelity.
Sen P, Dang W, Donahue G, Dai J, Dorsey J, Cao X, Liu W, Cao K, Perry R, Lee JY, Wasko BM, Carr DT, He C, Robison B, Wagner J, Gregory BD, Kaeberlein M, Kennedy BK, Boeke JD, Berger SL. Sen P, et al. Among authors: dang w. Genes Dev. 2015 Jul 1;29(13):1362-76. doi: 10.1101/gad.263707.115. Genes Dev. 2015. PMID: 26159996 Free PMC article.
Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response.
Dang W, Sutphin GL, Dorsey JA, Otte GL, Cao K, Perry RM, Wanat JJ, Saviolaki D, Murakami CJ, Tsuchiyama S, Robison B, Gregory BD, Vermeulen M, Shiekhattar R, Johnson FB, Kennedy BK, Kaeberlein M, Berger SL. Dang W, et al. Cell Metab. 2014 Jun 3;19(6):952-66. doi: 10.1016/j.cmet.2014.04.004. Epub 2014 May 8. Cell Metab. 2014. PMID: 24814484 Free PMC article.
Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence.
Sen P, Lan Y, Li CY, Sidoli S, Donahue G, Dou Z, Frederick B, Chen Q, Luense LJ, Garcia BA, Dang W, Johnson FB, Adams PD, Schultz DC, Berger SL. Sen P, et al. Among authors: dang w. Mol Cell. 2019 Feb 21;73(4):684-698.e8. doi: 10.1016/j.molcel.2019.01.021. Epub 2019 Feb 14. Mol Cell. 2019. PMID: 30773298 Free PMC article.
Regulation of stem cell aging by SIRT1 - Linking metabolic signaling to epigenetic modifications.
Yu A, Dang W. Yu A, et al. Among authors: dang w. Mol Cell Endocrinol. 2017 Nov 5;455:75-82. doi: 10.1016/j.mce.2017.03.031. Epub 2017 Apr 6. Mol Cell Endocrinol. 2017. PMID: 28392411 Review.
Sirtuins in yeast: phenotypes and tools.
Tsuchiyama S, Kwan E, Dang W, Bedalov A, Kennedy BK. Tsuchiyama S, et al. Among authors: dang w. Methods Mol Biol. 2013;1077:11-37. doi: 10.1007/978-1-62703-637-5_2. Methods Mol Biol. 2013. PMID: 24014397
Identification and characterization of novel sirtuin inhibitor scaffolds.
Sanders BD, Jackson B, Brent M, Taylor AM, Dang W, Berger SL, Schreiber SL, Howitz K, Marmorstein R. Sanders BD, et al. Among authors: dang w. Bioorg Med Chem. 2009 Oct 1;17(19):7031-41. doi: 10.1016/j.bmc.2009.07.073. Epub 2009 Aug 3. Bioorg Med Chem. 2009. PMID: 19734050 Free PMC article.
Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast.
Beaupere C, Dinatto L, Wasko BM, Chen RB, VanValkenburg L, Kiflezghi MG, Lee MB, Promislow DEL, Dang W, Kaeberlein M, Labunskyy VM. Beaupere C, et al. Among authors: dang w. Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9586-9591. doi: 10.1073/pnas.1804264115. Epub 2018 Sep 5. Proc Natl Acad Sci U S A. 2018. PMID: 30185560 Free PMC article.
High-throughput analysis of yeast replicative aging using a microfluidic system.
Jo MC, Liu W, Gu L, Dang W, Qin L. Jo MC, et al. Among authors: dang w. Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):9364-9. doi: 10.1073/pnas.1510328112. Epub 2015 Jul 13. Proc Natl Acad Sci U S A. 2015. PMID: 26170317 Free PMC article.
Histone methylation and aging: lessons learned from model systems.
McCauley BS, Dang W. McCauley BS, et al. Among authors: dang w. Biochim Biophys Acta. 2014 Dec;1839(12):1454-62. doi: 10.1016/j.bbagrm.2014.05.008. Epub 2014 May 21. Biochim Biophys Acta. 2014. PMID: 24859460 Free PMC article. Review.
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