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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2002 6
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2004 5
2005 5
2006 5
2007 3
2008 3
2009 3
2010 3
2011 5
2012 7
2013 3
2014 5
2015 4
2016 3
2017 6
2018 9
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2023 9
2024 2

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110 results

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Page 1
Plasmodium Egress Across the Parasite Life Cycle.
Dvorin JD, Goldberg DE. Dvorin JD, et al. Among authors: goldberg de. Annu Rev Microbiol. 2022 Sep 8;76:67-90. doi: 10.1146/annurev-micro-041320-020659. Epub 2022 Apr 13. Annu Rev Microbiol. 2022. PMID: 35417197 Review.
Human malaria, caused by infection with Plasmodium parasites, remains one of the most important global public health problems, with the World Health Organization reporting more than 240 million cases and 600,000 deaths annually as of 2020 (World malaria report 2021). ...Th …
Human malaria, caused by infection with Plasmodium parasites, remains one of the most important global public health problems, with t …
MalDA, Accelerating Malaria Drug Discovery.
Yang T, Ottilie S, Istvan ES, Godinez-Macias KP, Lukens AK, Baragaña B, Campo B, Walpole C, Niles JC, Chibale K, Dechering KJ, Llinás M, Lee MCS, Kato N, Wyllie S, McNamara CW, Gamo FJ, Burrows J, Fidock DA, Goldberg DE, Gilbert IH, Wirth DF, Winzeler EA; Malaria Drug Accelerator Consortium. Yang T, et al. Among authors: goldberg de. Trends Parasitol. 2021 Jun;37(6):493-507. doi: 10.1016/j.pt.2021.01.009. Epub 2021 Feb 26. Trends Parasitol. 2021. PMID: 33648890 Free PMC article. Review.
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase.
Xie SC, Wang Y, Morton CJ, Metcalfe RD, Dogovski C, Pasaje CFA, Dunn E, Luth MR, Kumpornsin K, Istvan ES, Park JS, Fairhurst KJ, Ketprasit N, Yeo T, Yildirim O, Bhebhe MN, Klug DM, Rutledge PJ, Godoy LC, Dey S, De Souza ML, Siqueira-Neto JL, Du Y, Puhalovich T, Amini M, Shami G, Loesbanluechai D, Nie S, Williamson N, Jana GP, Maity BC, Thomson P, Foley T, Tan DS, Niles JC, Han BW, Goldberg DE, Burrows J, Fidock DA, Lee MCS, Winzeler EA, Griffin MDW, Todd MH, Tilley L. Xie SC, et al. Among authors: goldberg de. Nat Commun. 2024 Jan 31;15(1):937. doi: 10.1038/s41467-024-45224-z. Nat Commun. 2024. PMID: 38297033 Free PMC article.
In vitro evolution of resistance using a slow ramp-up approach pointed to the Plasmodium falciparum cytoplasmic asparaginyl-tRNA synthetase (PfAsnRS) as the target, consistent with our finding that OSM-S-106 inhibits protein translation and activates the amino acid starvat …
In vitro evolution of resistance using a slow ramp-up approach pointed to the Plasmodium falciparum cytoplasmic asparaginyl-tRNA synt …
Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target.
Istvan ES, Guerra F, Abraham M, Huang KS, Rocamora F, Zhao H, Xu L, Pasaje C, Kumpornsin K, Luth MR, Cui H, Yang T, Palomo Diaz S, Gomez-Lorenzo MG, Qahash T, Mittal N, Ottilie S, Niles J, Lee MCS, Llinas M, Kato N, Okombo J, Fidock DA, Schimmel P, Gamo FJ, Goldberg DE, Winzeler EA. Istvan ES, et al. Among authors: goldberg de. Sci Transl Med. 2023 Mar 8;15(686):eadc9249. doi: 10.1126/scitranslmed.adc9249. Epub 2023 Mar 8. Sci Transl Med. 2023. PMID: 36888694 Free PMC article.
Purified recombinant P. vivax cIRS inhibition, cross-resistance, and biochemical assays indicated a noncompetitive, allosteric binding site that is distinct from that of known cIRS inhibitors mupirocin and reveromycin A. Our data show that Plasmodium cIRS is an important c …
Purified recombinant P. vivax cIRS inhibition, cross-resistance, and biochemical assays indicated a noncompetitive, allosteric binding site …
Plasmodium heme biosynthesis: To be or not to be essential?
Goldberg DE, Sigala PA. Goldberg DE, et al. PLoS Pathog. 2017 Sep 28;13(9):e1006511. doi: 10.1371/journal.ppat.1006511. eCollection 2017 Sep. PLoS Pathog. 2017. PMID: 28957449 Free PMC article. Review. No abstract available.
The peculiarities and paradoxes of Plasmodium heme metabolism.
Sigala PA, Goldberg DE. Sigala PA, et al. Among authors: goldberg de. Annu Rev Microbiol. 2014;68:259-78. doi: 10.1146/annurev-micro-091313-103537. Epub 2014 Jun 16. Annu Rev Microbiol. 2014. PMID: 25002093 Review.
For over a century, heme metabolism has been recognized to play a central role during intraerythrocytic infection by Plasmodium parasites, the causative agent of malaria. Parasites liberate vast quantities of potentially cytotoxic heme as a by-product of hemoglobin catabol …
For over a century, heme metabolism has been recognized to play a central role during intraerythrocytic infection by Plasmodium paras …
Human Polo-like Kinase Inhibitors as Antiplasmodials.
Bohmer MJ, Wang J, Istvan ES, Luth MR, Collins JE, Huttlin EL, Wang L, Mittal N, Hao M, Kwiatkowski NP, Gygi SP, Chakrabarti R, Deng X, Goldberg DE, Winzeler EA, Gray NS, Chakrabarti D. Bohmer MJ, et al. Among authors: goldberg de. ACS Infect Dis. 2023 Apr 14;9(4):1004-1021. doi: 10.1021/acsinfecdis.3c00025. Epub 2023 Mar 15. ACS Infect Dis. 2023. PMID: 36919909 Free PMC article.
Screening of additional PLK1 inhibitors revealed further antiplasmodial candidates despite the lack of an obvious orthologue of PLKs in Plasmodium. A subset of these inhibitors was profiled for their in vitro killing profile, and commonalities between the killing rate and …
Screening of additional PLK1 inhibitors revealed further antiplasmodial candidates despite the lack of an obvious orthologue of PLKs in P …
Toward a chemical vaccine for malaria.
Phillips MA, Goldberg DE. Phillips MA, et al. Among authors: goldberg de. Science. 2018 Dec 7;362(6419):1112-1113. doi: 10.1126/science.aav7479. Science. 2018. PMID: 30523095 No abstract available.
Hardly Vacuous: The Parasitophorous Vacuolar Membrane of Malaria Parasites.
Goldberg DE, Zimmerberg J. Goldberg DE, et al. Trends Parasitol. 2020 Feb;36(2):138-146. doi: 10.1016/j.pt.2019.11.006. Epub 2019 Dec 19. Trends Parasitol. 2020. PMID: 31866184 Free PMC article. Review.
Here, we review current understanding of the unique solutions Plasmodium has evolved to these challenges and discuss the remaining questions....
Here, we review current understanding of the unique solutions Plasmodium has evolved to these challenges and discuss the remaining qu …
Histidine-rich protein II nanoparticle delivery of heme iron load drives endothelial inflammation in cerebral malaria.
Nguyen ST, Du D, Wychrij D, Cain MD, Wu Q, Klein RS, Russo I, Goldberg DE. Nguyen ST, et al. Among authors: goldberg de. Proc Natl Acad Sci U S A. 2023 Jun 27;120(26):e2306318120. doi: 10.1073/pnas.2306318120. Epub 2023 Jun 12. Proc Natl Acad Sci U S A. 2023. PMID: 37307435 Free PMC article.
Histidine-rich protein II (HRPII) is secreted by Plasmodium falciparum during the blood stage of malaria infection. High plasma levels of HRPII are associated with cerebral malaria, a severe and highly fatal complication of malaria. ...
Histidine-rich protein II (HRPII) is secreted by Plasmodium falciparum during the blood stage of malaria infection. High plasma level …
110 results