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Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein.
Tamagno E, Guglielmotto M, Aragno M, Borghi R, Autelli R, Giliberto L, Muraca G, Danni O, Zhu X, Smith MA, Perry G, Jo DG, Mattson MP, Tabaton M. Tamagno E, et al. Among authors: danni o. J Neurochem. 2008 Feb;104(3):683-95. doi: 10.1111/j.1471-4159.2007.05072.x. Epub 2007 Nov 14. J Neurochem. 2008. PMID: 18005001 Free PMC article.
AGEs/RAGE complex upregulates BACE1 via NF-κB pathway activation.
Guglielmotto M, Aragno M, Tamagno E, Vercellinatto I, Visentin S, Medana C, Catalano MG, Smith MA, Perry G, Danni O, Boccuzzi G, Tabaton M. Guglielmotto M, et al. Among authors: danni o. Neurobiol Aging. 2012 Jan;33(1):196.e13-27. doi: 10.1016/j.neurobiolaging.2010.05.026. Epub 2010 Jul 17. Neurobiol Aging. 2012. PMID: 20638753 Free article.
63 results