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Camostat mesylate inhibits SARS-CoV-2 activation by TMPRSS2-related proteases and its metabolite GBPA exerts antiviral activity.
Hoffmann M, Hofmann-Winkler H, Smith JC, Krüger N, Arora P, Sørensen LK, Søgaard OS, Hasselstrøm JB, Winkler M, Hempel T, Raich L, Olsson S, Danov O, Jonigk D, Yamazoe T, Yamatsuta K, Mizuno H, Ludwig S, Noé F, Kjolby M, Braun A, Sheltzer JM, Pöhlmann S. Hoffmann M, et al. Among authors: danov o. EBioMedicine. 2021 Mar;65:103255. doi: 10.1016/j.ebiom.2021.103255. Epub 2021 Mar 4. EBioMedicine. 2021. PMID: 33676899 Free PMC article.
Synergistic inhibition of SARS-CoV-2 cell entry by otamixaban and covalent protease inhibitors: pre-clinical assessment of pharmacological and molecular properties.
Hempel T, Elez K, Krüger N, Raich L, Shrimp JH, Danov O, Jonigk D, Braun A, Shen M, Hall MD, Pöhlmann S, Hoffmann M, Noé F. Hempel T, et al. Among authors: danov o. Chem Sci. 2021 Aug 26;12(38):12600-12609. doi: 10.1039/d1sc01494c. eCollection 2021 Oct 6. Chem Sci. 2021. PMID: 34703545 Free PMC article.
Cyclosporin A Reveals Potent Antiviral Effects in Preclinical Models of SARS-CoV-2 Infection.
Sauerhering L, Kuznetsova I, Kupke A, Meier L, Halwe S, Rohde C, Schmidt J, Morty RE, Danov O, Braun A, Vadász I, Becker S, Herold S. Sauerhering L, et al. Among authors: danov o. Am J Respir Crit Care Med. 2022 Apr 15;205(8):964-968. doi: 10.1164/rccm.202108-1830LE. Am J Respir Crit Care Med. 2022. PMID: 35167409 Free PMC article. No abstract available.
Transcriptomic Analysis Reveals Priming of The Host Antiviral Interferon Signaling Pathway by Bronchobini® Resulting in Balanced Immune Response to Rhinovirus Infection in Mouse Lung Tissue Slices.
Reamon-Buettner SM, Niehof M, Hirth N, Danov O, Obernolte H, Braun A, Warnecke J, Sewald K, Wronski S. Reamon-Buettner SM, et al. Among authors: danov o. Int J Mol Sci. 2019 May 7;20(9):2242. doi: 10.3390/ijms20092242. Int J Mol Sci. 2019. PMID: 31067687 Free PMC article.
Human lung tissue provides highly relevant data about efficacy of new anti-asthmatic drugs.
Danov O, Jiménez Delgado SM, Obernolte H, Seehase S, Dehmel S, Braubach P, Fieguth HG, Matschiner G, Fitzgerald M, Jonigk D, Knauf S, Pfennig O, Warnecke G, Wichmann J, Braun A, Sewald K. Danov O, et al. PLoS One. 2018 Nov 30;13(11):e0207767. doi: 10.1371/journal.pone.0207767. eCollection 2018. PLoS One. 2018. PMID: 30500834 Free PMC article.
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