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Cyclohexyl-linked tricyclic isoxazoles are potent and selective modulators of the multidrug resistance protein (MRP1).
Norman BH, Lander PA, Gruber JM, Kroin JS, Cohen JD, Jungheim LN, Starling JJ, Law KL, Self TD, Tabas LB, Williams DC, Paul DC, Dantzig AH. Norman BH, et al. Among authors: dantzig ah. Bioorg Med Chem Lett. 2005 Dec 15;15(24):5526-30. doi: 10.1016/j.bmcl.2005.08.075. Epub 2005 Oct 3. Bioorg Med Chem Lett. 2005. PMID: 16202586
Kinetic validation of the use of carboxydichlorofluorescein as a drug surrogate for MRP5-mediated transport.
Pratt S, Chen V, Perry WI 3rd, Starling JJ, Dantzig AH. Pratt S, et al. Among authors: dantzig ah. Eur J Pharm Sci. 2006 Apr;27(5):524-32. doi: 10.1016/j.ejps.2005.09.012. Epub 2005 Dec 5. Eur J Pharm Sci. 2006. PMID: 16337112
GSH-dependent photolabeling of multidrug resistance protein MRP1 (ABCC1) by [125I]LY475776. Evidence of a major binding site in the COOH-proximal membrane spanning domain.
Mao Q, Qiu W, Weigl KE, Lander PA, Tabas LB, Shepard RL, Dantzig AH, Deeley RG, Cole SP. Mao Q, et al. Among authors: dantzig ah. J Biol Chem. 2002 Aug 9;277(32):28690-9. doi: 10.1074/jbc.M202182200. Epub 2002 May 28. J Biol Chem. 2002. PMID: 12034727
Human splicing factor SPF45 (RBM17) confers broad multidrug resistance to anticancer drugs when overexpressed--a phenotype partially reversed by selective estrogen receptor modulators.
Perry WL 3rd, Shepard RL, Sampath J, Yaden B, Chin WW, Iversen PW, Jin S, Lesoon A, O'Brien KA, Peek VL, Rolfe M, Shyjan A, Tighe M, Williamson M, Krishnan V, Moore RE, Dantzig AH. Perry WL 3rd, et al. Among authors: dantzig ah. Cancer Res. 2005 Aug 1;65(15):6593-600. doi: 10.1158/0008-5472.CAN-03-3675. Cancer Res. 2005. PMID: 16061639 Free article.
The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites.
Pratt S, Shepard RL, Kandasamy RA, Johnston PA, Perry W 3rd, Dantzig AH. Pratt S, et al. Among authors: dantzig ah. Mol Cancer Ther. 2005 May;4(5):855-63. doi: 10.1158/1535-7163.MCT-04-0291. Mol Cancer Ther. 2005. PMID: 15897250 Free article.
Evaluation of the binding of the tricyclic isoxazole photoaffinity label LY475776 to multidrug resistance associated protein 1 (MRP1) orthologs and several ATP- binding cassette (ABC) drug transporters.
Dantzig AH, Shepard RL, Pratt SE, Tabas LB, Lander PA, Ma L, Paul DC, Williams DC, Peng SB, Slapak CA, Godinot N, Perry WL 3rd. Dantzig AH, et al. Biochem Pharmacol. 2004 Mar 15;67(6):1111-21. doi: 10.1016/j.bcp.2003.11.006. Biochem Pharmacol. 2004. PMID: 15006547
Human SPF45, a splicing factor, has limited expression in normal tissues, is overexpressed in many tumors, and can confer a multidrug-resistant phenotype to cells.
Sampath J, Long PR, Shepard RL, Xia X, Devanarayan V, Sandusky GE, Perry WL 3rd, Dantzig AH, Williamson M, Rolfe M, Moore RE. Sampath J, et al. Among authors: dantzig ah. Am J Pathol. 2003 Nov;163(5):1781-90. doi: 10.1016/S0002-9440(10)63538-9. Am J Pathol. 2003. PMID: 14578179 Free PMC article.
Cloning and functional characterization of the multidrug resistance-associated protein (MRP1/ABCC1) from the cynomolgus monkey.
Godinot N, Iversen PW, Tabas L, Xia X, Williams DC, Dantzig AH, Perry WL 3rd. Godinot N, et al. Among authors: dantzig ah. Mol Cancer Ther. 2003 Mar;2(3):307-16. Mol Cancer Ther. 2003. PMID: 12657726
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