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Human splicing factor SPF45 (RBM17) confers broad multidrug resistance to anticancer drugs when overexpressed--a phenotype partially reversed by selective estrogen receptor modulators.
Perry WL 3rd, Shepard RL, Sampath J, Yaden B, Chin WW, Iversen PW, Jin S, Lesoon A, O'Brien KA, Peek VL, Rolfe M, Shyjan A, Tighe M, Williamson M, Krishnan V, Moore RE, Dantzig AH. Perry WL 3rd, et al. Among authors: dantzig ah. Cancer Res. 2005 Aug 1;65(15):6593-600. doi: 10.1158/0008-5472.CAN-03-3675. Cancer Res. 2005. PMID: 16061639 Free article.
Evaluation of the binding of the tricyclic isoxazole photoaffinity label LY475776 to multidrug resistance associated protein 1 (MRP1) orthologs and several ATP- binding cassette (ABC) drug transporters.
Dantzig AH, Shepard RL, Pratt SE, Tabas LB, Lander PA, Ma L, Paul DC, Williams DC, Peng SB, Slapak CA, Godinot N, Perry WL 3rd. Dantzig AH, et al. Biochem Pharmacol. 2004 Mar 15;67(6):1111-21. doi: 10.1016/j.bcp.2003.11.006. Biochem Pharmacol. 2004. PMID: 15006547
Human SPF45, a splicing factor, has limited expression in normal tissues, is overexpressed in many tumors, and can confer a multidrug-resistant phenotype to cells.
Sampath J, Long PR, Shepard RL, Xia X, Devanarayan V, Sandusky GE, Perry WL 3rd, Dantzig AH, Williamson M, Rolfe M, Moore RE. Sampath J, et al. Among authors: dantzig ah. Am J Pathol. 2003 Nov;163(5):1781-90. doi: 10.1016/S0002-9440(10)63538-9. Am J Pathol. 2003. PMID: 14578179 Free PMC article.
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