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Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice.
Pradere JP, Kluwe J, De Minicis S, Jiao JJ, Gwak GY, Dapito DH, Jang MK, Guenther ND, Mederacke I, Friedman R, Dragomir AC, Aloman C, Schwabe RF. Pradere JP, et al. Among authors: Dapito DH. Hepatology. 2013 Oct;58(4):1461-73. doi: 10.1002/hep.26429. Epub 2013 Aug 9. Hepatology. 2013. PMID: 23553591 Free PMC article.
Deactivation of hepatic stellate cells during liver fibrosis resolution in mice.
Troeger JS, Mederacke I, Gwak GY, Dapito DH, Mu X, Hsu CC, Pradere JP, Friedman RA, Schwabe RF. Troeger JS, et al. Among authors: Dapito DH. Gastroenterology. 2012 Oct;143(4):1073-83.e22. doi: 10.1053/j.gastro.2012.06.036. Epub 2012 Jun 27. Gastroenterology. 2012. PMID: 22750464 Free PMC article.
Toll-like receptor 4 and hepatic fibrogenesis.
Pradere JP, Troeger JS, Dapito DH, Mencin AA, Schwabe RF. Pradere JP, et al. Among authors: Dapito DH. Semin Liver Dis. 2010 Aug;30(3):232-44. doi: 10.1055/s-0030-1255353. Epub 2010 Jul 21. Semin Liver Dis. 2010. PMID: 20665376 Free PMC article. Review.
Absence of hepatic stellate cell retinoid lipid droplets does not enhance hepatic fibrosis but decreases hepatic carcinogenesis.
Kluwe J, Wongsiriroj N, Troeger JS, Gwak GY, Dapito DH, Pradere JP, Jiang H, Siddiqi M, Piantedosi R, O'Byrne SM, Blaner WS, Schwabe RF. Kluwe J, et al. Among authors: Dapito DH. Gut. 2011 Sep;60(9):1260-8. doi: 10.1136/gut.2010.209551. Epub 2011 Jan 27. Gut. 2011. PMID: 21278145
High-mobility group box 1 is dispensable for autophagy, mitochondrial quality control, and organ function in vivo.
Huebener P, Gwak GY, Pradere JP, Quinzii CM, Friedman R, Lin CS, Trent CM, Mederacke I, Zhao E, Dapito DH, Lin Y, Goldberg IJ, Czaja MJ, Schwabe RF. Huebener P, et al. Among authors: Dapito DH. Cell Metab. 2014 Mar 4;19(3):539-47. doi: 10.1016/j.cmet.2014.01.014. Cell Metab. 2014. PMID: 24606906 Free PMC article.
CCL20 mediates lipopolysaccharide induced liver injury and is a potential driver of inflammation and fibrosis in alcoholic hepatitis.
Affò S, Morales-Ibanez O, Rodrigo-Torres D, Altamirano J, Blaya D, Dapito DH, Millán C, Coll M, Caviglia JM, Arroyo V, Caballería J, Schwabe RF, Ginès P, Bataller R, Sancho-Bru P. Affò S, et al. Among authors: Dapito DH. Gut. 2014 Nov;63(11):1782-92. doi: 10.1136/gutjnl-2013-306098. Epub 2014 Jan 10. Gut. 2014. PMID: 24415562 Free PMC article.
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