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Targeted inactivation of the 25-hydroxyvitamin D(3)-1(alpha)-hydroxylase gene (CYP27B1) creates an animal model of pseudovitamin D-deficiency rickets.
Dardenne O, Prud'homme J, Arabian A, Glorieux FH, St-Arnaud R. Dardenne O, et al. Endocrinology. 2001 Jul;142(7):3135-41. doi: 10.1210/endo.142.7.8281. Endocrinology. 2001. PMID: 11416036
25 Hydroxyvitamin D 1 alpha-hydroxylase is required for optimal epidermal differentiation and permeability barrier homeostasis.
Bikle DD, Chang S, Crumrine D, Elalieh H, Man MQ, Choi EH, Dardenne O, Xie Z, Arnaud RS, Feingold K, Elias PM. Bikle DD, et al. Among authors: dardenne o. J Invest Dermatol. 2004 Apr;122(4):984-92. doi: 10.1111/j.0022-202X.2004.22424.x. J Invest Dermatol. 2004. PMID: 15102089 Free article.
Correction of the abnormal mineral ion homeostasis with a high-calcium, high-phosphorus, high-lactose diet rescues the PDDR phenotype of mice deficient for the 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1).
Dardenne O, Prud'homme J, Hacking SA, Glorieux FH, St-Arnaud R. Dardenne O, et al. Bone. 2003 Apr;32(4):332-40. doi: 10.1016/s8756-3282(03)00023-1. Bone. 2003. PMID: 12689675
Modulation of renal Ca2+ transport protein genes by dietary Ca2+ and 1,25-dihydroxyvitamin D3 in 25-hydroxyvitamin D3-1alpha-hydroxylase knockout mice.
Hoenderop JG, Dardenne O, Van Abel M, Van Der Kemp AW, Van Os CH, St -Arnaud R, Bindels RJ. Hoenderop JG, et al. Among authors: dardenne o. FASEB J. 2002 Sep;16(11):1398-406. doi: 10.1096/fj.02-0225com. FASEB J. 2002. PMID: 12205031
Chondrocyte-specific modulation of Cyp27b1 expression supports a role for local synthesis of 1,25-dihydroxyvitamin D3 in growth plate development.
Naja RP, Dardenne O, Arabian A, St Arnaud R. Naja RP, et al. Among authors: dardenne o. Endocrinology. 2009 Sep;150(9):4024-32. doi: 10.1210/en.2008-1410. Epub 2009 May 28. Endocrinology. 2009. PMID: 19477943
Rescue of the phenotype of CYP27B1 (1alpha-hydroxylase)-deficient mice.
Dardenne O, Prud'homme J, Glorieux FH, St-Arnaud R. Dardenne O, et al. J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):327-30. doi: 10.1016/j.jsbmb.2004.03.026. J Steroid Biochem Mol Biol. 2004. PMID: 15225794
Conventional and tissue-specific inactivation of the 25-hydroxyvitamin D-1alpha-hydroxylase (CYP27B1).
St-Arnaud R, Dardenne O, Prud'homme J, Hacking SA, Glorieux FH. St-Arnaud R, et al. Among authors: dardenne o. J Cell Biochem. 2003 Feb 1;88(2):245-51. doi: 10.1002/jcb.10348. J Cell Biochem. 2003. PMID: 12520522
Rescue of the pseudo-vitamin D deficiency rickets phenotype of CYP27B1-deficient mice by treatment with 1,25-dihydroxyvitamin D3: biochemical, histomorphometric, and biomechanical analyses.
Dardenne O, Prudhomme J, Hacking SA, Glorieux FH, St-Arnaud R. Dardenne O, et al. J Bone Miner Res. 2003 Apr;18(4):637-43. doi: 10.1359/jbmr.2003.18.4.637. J Bone Miner Res. 2003. PMID: 12674324
Mice lacking 25OHD 1alpha-hydroxylase demonstrate decreased epidermal differentiation and barrier function.
Bikle DD, Chang S, Crumrine D, Elalieh H, Man MQ, Dardenne O, Xie Z, Arnaud RS, Feingold K, Elias PM. Bikle DD, et al. Among authors: dardenne o. J Steroid Biochem Mol Biol. 2004 May;89-90(1-5):347-53. doi: 10.1016/j.jsbmb.2004.03.113. J Steroid Biochem Mol Biol. 2004. PMID: 15225799
1,25-dihydroxyvitamin D(3)-independent stimulatory effect of estrogen on the expression of ECaC1 in the kidney.
Van Abel M, Hoenderop JG, Dardenne O, St Arnaud R, Van Os CH, Van Leeuwen HJ, Bindels RJ. Van Abel M, et al. Among authors: dardenne o. J Am Soc Nephrol. 2002 Aug;13(8):2102-9. doi: 10.1097/01.asn.0000022423.34922.2a. J Am Soc Nephrol. 2002. PMID: 12138142
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