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Pre-mRNA processing includes N6 methylation of adenosine residues that are retained in mRNA exons and the fallacy of "RNA epigenetics".
Darnell RB, Ke S, Darnell JE Jr. Darnell RB, et al. Among authors: darnell je jr. RNA. 2018 Mar;24(3):262-267. doi: 10.1261/rna.065219.117. Epub 2017 Dec 8. RNA. 2018. PMID: 29222117 Free PMC article.
m6A mRNA modifications are deposited in nascent pre-mRNA and are not required for splicing but do specify cytoplasmic turnover.
Ke S, Pandya-Jones A, Saito Y, Fak JJ, Vågbø CB, Geula S, Hanna JH, Black DL, Darnell JE Jr, Darnell RB. Ke S, et al. Among authors: darnell je jr. Genes Dev. 2017 May 15;31(10):990-1006. doi: 10.1101/gad.301036.117. Genes Dev. 2017. PMID: 28637692 Free PMC article.
A majority of m6A residues are in the last exons, allowing the potential for 3' UTR regulation.
Ke S, Alemu EA, Mertens C, Gantman EC, Fak JJ, Mele A, Haripal B, Zucker-Scharff I, Moore MJ, Park CY, Vågbø CB, Kusśnierczyk A, Klungland A, Darnell JE Jr, Darnell RB. Ke S, et al. Among authors: darnell je jr. Genes Dev. 2015 Oct 1;29(19):2037-53. doi: 10.1101/gad.269415.115. Epub 2015 Sep 24. Genes Dev. 2015. PMID: 26404942 Free PMC article.
Joys and surprises of a career studying eukaryotic gene expression.
Darnell JE Jr. Darnell JE Jr. J Biol Chem. 2013 May 3;288(18):12957-66. doi: 10.1074/jbc.X113.471722. Epub 2013 Mar 22. J Biol Chem. 2013. PMID: 23525107 Free PMC article.
Reflections on the history of pre-mRNA processing and highlights of current knowledge: a unified picture.
Darnell JE Jr. Darnell JE Jr. RNA. 2013 Apr;19(4):443-60. doi: 10.1261/rna.038596.113. Epub 2013 Feb 25. RNA. 2013. PMID: 23440351 Free PMC article. Review.
The JAK-STAT pathway at twenty.
Stark GR, Darnell JE Jr. Stark GR, et al. Among authors: darnell je jr. Immunity. 2012 Apr 20;36(4):503-14. doi: 10.1016/j.immuni.2012.03.013. Immunity. 2012. PMID: 22520844 Free PMC article. Review.
The JAK-STAT pathway at 20.
Darnell JE Jr. Darnell JE Jr. JAKSTAT. 2012 Jan 1;1(1):2. doi: 10.4161/jkst.18726. JAKSTAT. 2012. PMID: 24058745 Free PMC article. No abstract available.
Pillars article: Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science. 1992. 257: 809-813.
Schindler C, Shuai K, Prezioso VR, Darnell JE Jr. Schindler C, et al. Among authors: darnell je jr. J Immunol. 2011 Dec 1;187(11):5489-94. J Immunol. 2011. PMID: 22102732 Free article. No abstract available.
STAT3, HIF-1, glucose addiction and Warburg effect.
Darnell JE Jr. Darnell JE Jr. Aging (Albany NY). 2010 Dec;2(12):890-1. doi: 10.18632/aging.100239. Aging (Albany NY). 2010. PMID: 21149895 Free PMC article. No abstract available.
Obituary: Hidesaburo Hanafusa (1929-2009).
Foster DA, Darnell JE Jr. Foster DA, et al. Among authors: darnell je jr. Nature. 2009 Apr 9;458(7239):718. doi: 10.1038/458718a. Nature. 2009. PMID: 19360078 No abstract available.
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