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Experimental strategies for the genetic dissection of complex traits in animal models.
Darvasi A. Darvasi A. Nat Genet. 1998 Jan;18(1):19-24. doi: 10.1038/ng0198-19. Nat Genet. 1998. PMID: 9425894
A major obstacle lies in achieving fine mapping resolution for the detected loci. Compared to the rapid development of sophisticated statistical and molecular tools, development and analysis of experimental designs for various stages in QTL mapping experiments have barely
A major obstacle lies in achieving fine mapping resolution for the detected loci. Compared to the rapid development of sophisticated
Identification of loci associated with schizophrenia by genome-wide association and follow-up.
O'Donovan MC, Craddock N, Norton N, Williams H, Peirce T, Moskvina V, Nikolov I, Hamshere M, Carroll L, Georgieva L, Dwyer S, Holmans P, Marchini JL, Spencer CC, Howie B, Leung HT, Hartmann AM, Möller HJ, Morris DW, Shi Y, Feng G, Hoffmann P, Propping P, Vasilescu C, Maier W, Rietschel M, Zammit S, Schumacher J, Quinn EM, Schulze TG, Williams NM, Giegling I, Iwata N, Ikeda M, Darvasi A, Shifman S, He L, Duan J, Sanders AR, Levinson DF, Gejman PV, Cichon S, Nöthen MM, Gill M, Corvin A, Rujescu D, Kirov G, Owen MJ, Buccola NG, Mowry BJ, Freedman R, Amin F, Black DW, Silverman JM, Byerley WF, Cloninger CR; Molecular Genetics of Schizophrenia Collaboration. O'Donovan MC, et al. Nat Genet. 2008 Sep;40(9):1053-5. doi: 10.1038/ng.201. Nat Genet. 2008. PMID: 18677311
We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10(-5) in up to 16,726 additional subjects. ...

We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10(-5) in up

Dissecting complex traits: the geneticists' "Around the world in 80 days".
Darvasi A. Darvasi A. Trends Genet. 2005 Jul;21(7):373-6. doi: 10.1016/j.tig.2005.05.003. Trends Genet. 2005. PMID: 15913834 Review.
The identification of genes mildly affecting quantitative phenotypes constitutes a difficult task that has almost always eluded application, particularly in behavioral phenotypes. Recently, the first study that identified a gene underlying a QTL affecting anx …
The identification of genes mildly affecting quantitative phenotypes constitutes a difficult task that has almost always eluded appli …
Mouse inbred strain sequence information and yin-yang crosses for quantitative trait locus fine mapping.
Shifman S, Darvasi A. Shifman S, et al. Genetics. 2005 Feb;169(2):849-54. doi: 10.1534/genetics.104.032474. Epub 2004 Nov 1. Genetics. 2005. PMID: 15520253 Free PMC article.
Here we suggest and evaluate a general approach, which consists of crossing the two strains used initially to map the QTL and any new strain. ...This suggests that with a large number of strains in hand, selecting a small number of strains may provide a
Here we suggest and evaluate a general approach, which consists of crossing the two strains used initially to map the QTL and any new …
Complexities in the genetic dissection of quantitative trait loci.
Darvasi A, Pisanté-Shalom A. Darvasi A, et al. Trends Genet. 2002 Oct;18(10):489-91. doi: 10.1016/s0168-9525(02)02767-1. Trends Genet. 2002. PMID: 12350331
Recently, Steinmetz et al. used a new technique to produce the first complete quantitative trait locus (QTL) analysis of a complex trait from phenotype to gene to be published entirely in a single report. This marks a significant advance over previous …
Recently, Steinmetz et al. used a new technique to produce the first complete quantitative trait locus (QTL) analysis of a com …
An integrated in silico gene mapping strategy in inbred mice.
Cervino AC, Darvasi A, Fallahi M, Mader CC, Tsinoremas NF. Cervino AC, et al. Genetics. 2007 Jan;175(1):321-33. doi: 10.1534/genetics.106.065359. Epub 2006 Oct 8. Genetics. 2007. PMID: 17028314 Free PMC article.
In recent years in silico analysis of common laboratory mice has been introduced and subsequently applied, in slightly different ways, as a methodology for gene mapping. ...Third, we introduced a novel statistical approach: a cladistic analysis, which is well …
In recent years in silico analysis of common laboratory mice has been introduced and subsequently applied, in slightly different ways, as …
An integrative approach for the identification of quantitative trait loci.
Arbilly M, Pisanté A, Devor M, Darvasi A. Arbilly M, et al. Anim Genet. 2006 Aug;37 Suppl 1:7-9. doi: 10.1111/j.1365-2052.2006.01472.x. Anim Genet. 2006. PMID: 16886995
This approach makes use of the wealth of genetic tools available in mice, as well as the recent advances in genome sequence data already available for a number of inbred mouse strains. We have developed mapping strategies that allow a stepwise narrowing of a
This approach makes use of the wealth of genetic tools available in mice, as well as the recent advances in genome sequence data already ava …
A simple method to calculate resolving power and confidence interval of QTL map location.
Darvasi A, Soller M. Darvasi A, et al. Behav Genet. 1997 Mar;27(2):125-32. doi: 10.1023/a:1025685324830. Behav Genet. 1997. PMID: 9145551
"Resolving power" is defined as the 95% confidence interval for quantitative trait locus (QTL) map location that would be obtained when scoring an infinite number of markers in a given constellation of a marker-QTL mapping experiment. Resolving power can serve as …
"Resolving power" is defined as the 95% confidence interval for quantitative trait locus (QTL) map location that would be obtained when scor …
Advanced intercross lines, an experimental population for fine genetic mapping.
Darvasi A, Soller M. Darvasi A, et al. Genetics. 1995 Nov;141(3):1199-207. Genetics. 1995. PMID: 8582624 Free PMC article.
An AIL is produced by randomly and sequentially intercrossing a population that initially originated from a cross between two inbred lines or some variant thereof. ...It is proposed that AILs derived from crosses between known inbred lines may be a useful res …
An AIL is produced by randomly and sequentially intercrossing a population that initially originated from a cross between two …
Detecting marker-QTL linkage and estimating QTL gene effect and map location using a saturated genetic map.
Darvasi A, Weinreb A, Minke V, Weller JI, Soller M. Darvasi A, et al. Genetics. 1993 Jul;134(3):943-51. Genetics. 1993. PMID: 8349116 Free PMC article.
A simulation study was carried out on a backcross population in order to determine the effect of marker spacing, gene effect and population size on the power of marker-quantitative trait loci (QTL) linkage experiments and on the standard error of maximum likelihood
A simulation study was carried out on a backcross population in order to determine the effect of marker spacing, gene effect a
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