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Use of microarray analysis to unveil transcription factor and gene networks contributing to Beta cell dysfunction and apoptosis.
Eizirik DL, Kutlu B, Rasschaert J, Darville M, Cardozo AK. Eizirik DL, et al. Among authors: darville m. Ann N Y Acad Sci. 2003 Nov;1005:55-74. doi: 10.1196/annals.1288.007. Ann N Y Acad Sci. 2003. PMID: 14679040
Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways.
Karlsen AE, Heding PE, Frobøse H, Rønn SG, Kruhøffer M, Orntoft TF, Darville M, Eizirik DL, Pociot F, Nerup J, Mandrup-Poulsen T, Billestrup N. Karlsen AE, et al. Among authors: darville m. Diabetologia. 2004 Nov;47(11):1998-2011. doi: 10.1007/s00125-004-1568-3. Epub 2004 Dec 2. Diabetologia. 2004. PMID: 15578154
Double-stranded ribonucleic acid (RNA) induces beta-cell Fas messenger RNA expression and increases cytokine-induced beta-cell apoptosis.
Liu D, Darville M, Eizirik DL. Liu D, et al. Among authors: darville m. Endocrinology. 2001 Jun;142(6):2593-9. doi: 10.1210/endo.142.6.8188. Endocrinology. 2001. PMID: 11356709
Inhibition of cytokine-induced NF-kappaB activation by adenovirus-mediated expression of a NF-kappaB super-repressor prevents beta-cell apoptosis.
Heimberg H, Heremans Y, Jobin C, Leemans R, Cardozo AK, Darville M, Eizirik DL. Heimberg H, et al. Among authors: darville m. Diabetes. 2001 Oct;50(10):2219-24. doi: 10.2337/diabetes.50.10.2219. Diabetes. 2001. PMID: 11574401
Macrophages enhance the radiosensitizing activity of lipid A: a novel role for immune cells in tumor cell radioresponse.
De Ridder M, Verovski VN, Darville MI, Van Den Berge DL, Monsaert C, Eizirik DL, Storme GA. De Ridder M, et al. Among authors: darville mi. Int J Radiat Oncol Biol Phys. 2004 Oct 1;60(2):598-606. doi: 10.1016/j.ijrobp.2004.05.065. Int J Radiat Oncol Biol Phys. 2004. PMID: 15380597
An octamer motif is required for activation of the inducible nitric oxide synthase promoter in pancreatic beta-cells.
Darville MI, Terryn S, Eizirik DL. Darville MI, et al. Endocrinology. 2004 Mar;145(3):1130-6. doi: 10.1210/en.2003-1200. Epub 2003 Nov 20. Endocrinology. 2004. PMID: 14630716
Discovery of gene networks regulating cytokine-induced dysfunction and apoptosis in insulin-producing INS-1 cells.
Kutlu B, Cardozo AK, Darville MI, Kruhøffer M, Magnusson N, Ørntoft T, Eizirik DL. Kutlu B, et al. Among authors: darville mi. Diabetes. 2003 Nov;52(11):2701-19. doi: 10.2337/diabetes.52.11.2701. Diabetes. 2003. PMID: 14578289 Free article.
Double-stranded RNA cooperates with interferon-gamma and IL-1 beta to induce both chemokine expression and nuclear factor-kappa B-dependent apoptosis in pancreatic beta-cells: potential mechanisms for viral-induced insulitis and beta-cell death in type 1 diabetes mellitus.
Liu D, Cardozo AK, Darville MI, Eizirik DL. Liu D, et al. Among authors: darville mi. Endocrinology. 2002 Apr;143(4):1225-34. doi: 10.1210/endo.143.4.8737. Endocrinology. 2002. PMID: 11897677
Molecular regulation of monocyte chemoattractant protein-1 expression in pancreatic beta-cells.
Kutlu B, Darville MI, Cardozo AK, Eizirik DL. Kutlu B, et al. Among authors: darville mi. Diabetes. 2003 Feb;52(2):348-55. doi: 10.2337/diabetes.52.2.348. Diabetes. 2003. PMID: 12540607 Free article.
Notch signaling: a mediator of beta-cell de-differentiation in diabetes?
Darville MI, Eizirik DL. Darville MI, et al. Biochem Biophys Res Commun. 2006 Jan 27;339(4):1063-8. doi: 10.1016/j.bbrc.2005.11.111. Epub 2005 Dec 1. Biochem Biophys Res Commun. 2006. PMID: 16337608
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