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Suppressor of cytokine signalling (SOCS)-3 protects beta cells against IL-1beta-mediated toxicity through inhibition of multiple nuclear factor-kappaB-regulated proapoptotic pathways.
Karlsen AE, Heding PE, Frobøse H, Rønn SG, Kruhøffer M, Orntoft TF, Darville M, Eizirik DL, Pociot F, Nerup J, Mandrup-Poulsen T, Billestrup N. Karlsen AE, et al. Diabetologia. 2004 Nov;47(11):1998-2011. doi: 10.1007/s00125-004-1568-3. Epub 2004 Dec 2. Diabetologia. 2004. PMID: 15578154
Double-stranded RNA cooperates with interferon-gamma and IL-1 beta to induce both chemokine expression and nuclear factor-kappa B-dependent apoptosis in pancreatic beta-cells: potential mechanisms for viral-induced insulitis and beta-cell death in type 1 diabetes mellitus.
Liu D, Cardozo AK, Darville MI, Eizirik DL. Liu D, et al. Among authors: darville mi. Endocrinology. 2002 Apr;143(4):1225-34. doi: 10.1210/endo.143.4.8737. Endocrinology. 2002. PMID: 11897677
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