Das K - Search Results

1

Phenyl substituted 4-hydroxypyridazin-3(2H)-ones and 5-hydroxypyrimidin-4(3H)-ones: inhibitors of influenza A endonuclease.

Sagong HY, Bauman JD, Patel D, Das K, Arnold E, LaVoie EJ. Sagong HY, et al. Among authors: das k. J Med Chem. 2014 Oct 9;57(19):8086-98. doi: 10.1021/jm500958x. Epub 2014 Sep 29. J Med Chem. 2014. PMID: 25225968 Free PMC article.

2

Crystal structure of tert-butyldimethylsilyl-spiroaminooxathioledioxide-thymine (TSAO-T) in complex with HIV-1 reverse transcriptase (RT) redefines the elastic limits of the non-nucleoside inhibitor-binding pocket.

Das K, Bauman JD, Rim AS, Dharia C, Clark AD Jr, Camarasa MJ, Balzarini J, Arnold E. Das K, et al. J Med Chem. 2011 Apr 28;54(8):2727-37. doi: 10.1021/jm101536x. Epub 2011 Mar 29. J Med Chem. 2011. PMID: 21446702 Free PMC article.

3

Detecting allosteric sites of HIV-1 reverse transcriptase by X-ray crystallographic fragment screening.

Bauman JD, Patel D, Dharia C, Fromer MW, Ahmed S, Frenkel Y, Vijayan RS, Eck JT, Ho WC, Das K, Shatkin AJ, Arnold E. Bauman JD, et al. Among authors: das k. J Med Chem. 2013 Apr 11;56(7):2738-46. doi: 10.1021/jm301271j. Epub 2013 Feb 20. J Med Chem. 2013. PMID: 23342998 Free PMC article.

4

Crystallographic fragment screening and structure-based optimization yields a new class of influenza endonuclease inhibitors.

Bauman JD, Patel D, Baker SF, Vijayan RS, Xiang A, Parhi AK, Martínez-Sobrido L, LaVoie EJ, Das K, Arnold E. Bauman JD, et al. Among authors: das k. ACS Chem Biol. 2013 Nov 15;8(11):2501-8. doi: 10.1021/cb400400j. Epub 2013 Sep 13. ACS Chem Biol. 2013. PMID: 23978130 Free PMC article.

5

Phenyl substituted 3-hydroxypyridin-2(1H)-ones: inhibitors of influenza A endonuclease.

Parhi AK, Xiang A, Bauman JD, Patel D, Vijayan RS, Das K, Arnold E, Lavoie EJ. Parhi AK, et al. Among authors: das k. Bioorg Med Chem. 2013 Nov 1;21(21):6435-46. doi: 10.1016/j.bmc.2013.08.053. Epub 2013 Sep 4. Bioorg Med Chem. 2013. PMID: 24055080

6

3-Hydroxyquinolin-2(1H)-ones As Inhibitors of Influenza A Endonuclease.

Sagong HY, Parhi A, Bauman JD, Patel D, Vijayan RS, Das K, Arnold E, LaVoie EJ. Sagong HY, et al. Among authors: das k. ACS Med Chem Lett. 2013 May 7;4(6):547-50. doi: 10.1021/ml4001112. eCollection 2013 Jun 13. ACS Med Chem Lett. 2013. PMID: 24936242 Free PMC article.

7

Pronounced Inhibition Shift from HIV Reverse Transcriptase to Herpetic DNA Polymerases by Increasing the Flexibility of α-Carboxy Nucleoside Phosphonates.

John J, Kim Y, Bennett N, Das K, Liekens S, Naesens L, Arnold E, Maguire AR, Götte M, Dehaen W, Balzarini J. John J, et al. Among authors: das k. J Med Chem. 2015 Oct 22;58(20):8110-27. doi: 10.1021/acs.jmedchem.5b01180. Epub 2015 Oct 9. J Med Chem. 2015. PMID: 26450273 Free PMC article.

8

HIV-1 gp120 Antagonists Also Inhibit HIV-1 Reverse Transcriptase by Bridging the NNRTI and NRTI Sites.

Losada N, Ruiz FX, Curreli F, Gruber K, Pilch A, Das K, Debnath AK, Arnold E. Losada N, et al. Among authors: das k. J Med Chem. 2021 Nov 25;64(22):16530-16540. doi: 10.1021/acs.jmedchem.1c01104. Epub 2021 Nov 4. J Med Chem. 2021. PMID: 34735153 Free PMC article.

9

Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants.

Das K, Clark AD Jr, Lewi PJ, Heeres J, De Jonge MR, Koymans LM, Vinkers HM, Daeyaert F, Ludovici DW, Kukla MJ, De Corte B, Kavash RW, Ho CY, Ye H, Lichtenstein MA, Andries K, Pauwels R, De Béthune MP, Boyer PL, Clark P, Hughes SH, Janssen PA, Arnold E. Das K, et al. J Med Chem. 2004 May 6;47(10):2550-60. doi: 10.1021/jm030558s. J Med Chem. 2004. PMID: 15115397

10

Concentration and pH dependent aggregation of hydrophobic drug molecules and relevance to oral bioavailability.

Frenkel YV, Clark AD Jr, Das K, Wang YH, Lewi PJ, Janssen PA, Arnold E. Frenkel YV, et al. Among authors: das k. J Med Chem. 2005 Mar 24;48(6):1974-83. doi: 10.1021/jm049439i. J Med Chem. 2005. PMID: 15771441

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