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Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase.
Bago R, Malik N, Munson MJ, Prescott AR, Davies P, Sommer E, Shpiro N, Ward R, Cross D, Ganley IG, Alessi DR. Bago R, et al. Among authors: davies p. Biochem J. 2014 Nov 1;463(3):413-27. doi: 10.1042/BJ20140889. Biochem J. 2014. PMID: 25177796 Free PMC article.
Photoactivatable Prodrugs of Antimelanoma Agent Vemurafenib.
Horbert R, Pinchuk B, Davies P, Alessi D, Peifer C. Horbert R, et al. Among authors: davies p. ACS Chem Biol. 2015 Sep 18;10(9):2099-107. doi: 10.1021/acschembio.5b00174. Epub 2015 Jul 10. ACS Chem Biol. 2015. PMID: 26061392
Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain.
Zhang J, Gao G, Begum G, Wang J, Khanna AR, Shmukler BE, Daubner GM, de Los Heros P, Davies P, Varghese J, Bhuiyan MI, Duan J, Zhang J, Duran D, Alper SL, Sun D, Elledge SJ, Alessi DR, Kahle KT. Zhang J, et al. Among authors: davies p. Sci Rep. 2016 Oct 26;6:35986. doi: 10.1038/srep35986. Sci Rep. 2016. PMID: 27782176 Free PMC article.
LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages.
Härtlova A, Herbst S, Peltier J, Rodgers A, Bilkei-Gorzo O, Fearns A, Dill BD, Lee H, Flynn R, Cowley SA, Davies P, Lewis PA, Ganley IG, Martinez J, Alessi DR, Reith AD, Trost M, Gutierrez MG. Härtlova A, et al. Among authors: davies p. EMBO J. 2018 Jun 15;37(12):e98694. doi: 10.15252/embj.201798694. Epub 2018 May 22. EMBO J. 2018. PMID: 29789389 Free PMC article.
Development of a highly potent and selective degrader of LRRK2.
Hatcher JM, Zwirek M, Sarhan AR, Vatsan PS, Tonelli F, Alessi DR, Davies P, Gray NS. Hatcher JM, et al. Among authors: davies p. Bioorg Med Chem Lett. 2023 Oct 1;94:129449. doi: 10.1016/j.bmcl.2023.129449. Epub 2023 Aug 15. Bioorg Med Chem Lett. 2023. PMID: 37591317
3,907 results